The invention relates to the technical field of photon counting imaging detection, and particularly relates to a position-sensitive anode detector and a manufacturing method thereof. The detector comprises a cathode window having a photoelectric cathode, an MCP electron multiplier, a position-sensitive anode and a tubular shell. The position-sensitive anode comprises an anode insulating substrate and a metal film anode which is arranged on the anode insulating substrate. According to the metal film anode, nxn independent anodes are arranged in parallel along a horizontal direction to form an anode array, each independent anode is square and an insulating channel is arranged between the adjacent independent anodes. Each independent anode electrode lead perpendicularly penetrates through the anode insulating substrate. Manufacturing of the detector is completed by the steps of sealing of the tubular shell, indium tubular shell, vapor plating of the cathode window metal film, manufacturing the anode insulating substrate, manufacturing the metal film anode, assembling the detector component, manufacturing the photoelectric cathode and indium sealing of the detector. The detector has a large dynamic range and can work under the condition of single photon incident light and can also work under the condition of strong incident light.