The invention relates to a topology control method for wireless sensor network based on uneven cluster, belong to sensor technical field, comprising: during the topology generating stage, introducing an uneven minimum mean square subtraction clustering mechanism on a finished cluster in order to reduce energy consumption of in-cluster node; using a strategy based on cluster head energy consumption for setting cluster head changing time, in order to equalize energy consumption on each cluster head node in the network; establishing a cluster head-cluster head energy sensing route, in order to avoid remote wireless transmission; during topology maintenance stage, using a cluster head selection scheme based on node surplus energy and in-cluster node distribution, and using the same strategy to set cluster changing time. With the realization of the method, it can reduce total network energy consumption and equalize energy consumption on each node, in order to prolong cooperative working time of most nodes in the network.