Biocompatible implantable sensor apparatus and methods of implantation and use. In one embodiment, the sensor apparatus is an
oxygen-based glucose sensor having
biocompatibility features that mitigate the
host tissue response. In one variant, these features include use of a non-enzymatic membrane over each of the individual
analyte detectors so as to preclude contact of the surrounding tissue with the underlying
enzyme or other matrix, and mitigate vascularization, and insulation of the various electrodes and associated electrolytic processes of the sensor from the surrounding tissue. In one implementation, the sensor region of the implanted apparatus is configured to
interlock or imprint the surrounding tissue so as to promote a high degree of glucose molecule
diffusion into the individual detectors, and a constant and predictable sensor to
blood vessel interface, yet preclude the tissue from bonding to the sensor, especially over extended periods of
implant.