The invention discloses a self-adaptive large neighborhood search method for AEOS (agile earth observation satellite) scheduling. The method comprises following steps: Step 1, a constraint satisfaction model of AEOS scheduling problems is established; Step 2, an initial liquid is solved and taken as a current liquid; Step 3, adjustment is performed in a neighborhood of the current liquid: a deletion operator is selected, part of masks is deleted, and a destruction liquid is obtained; an insertion operator is selected, masks are inserted into the destruction liquid, and a new liquid is obtained; Step 4, the benefit of the new liquid is calculated and compared with benefits of the current liquid and an optimal liquid, and the current liquid and the optimal liquid are updated; Step 5, operator scores are updated according to operator performance; operator weights are updated after iteration is performed preset times each time; Step 6, the optimal liquid is output if an end condition is met, otherwise, the Step 3 is executed. Aiming at the time-dependent characteristic of the AEOS scheduling problems, the constraint satisfaction model of the AEOS scheduling problems is established by adopting the maximum observation benefit as a target, a liquid framework based on self-adaptive large neighborhood search is provided, and a conflict-free scheduling scheme is generated.