The invention relates to a non-purlin bolt ball node grid structure and a manufacturing method thereof. The non-purlin bolt ball node grid structure comprises upper chord members, web members, lower chord members and bolt ball nodes. The bolt ball nodes comprise high-strength bolts, sleeves, solid spheres and pins, the upper chord members, the web members and the lower chord members pass through the solid spheres, the upper chord members adopt square steel tubes or rectangular steel tubes, two sides of the upper chord members are horizontally arranged and two sides are vertically arranged, and the diameter of the bolt ball nodes connecting the upper chord members is no more than the vertical side length of the upper chord members. In the invention, all of the members can realize industrial production and are connected by the bolts on field, field welding is avoided, construction period and construction cost are shortened, purlines are not arranged at the same time, steel products are saved, and construction costs are reduced.