The invention provides a preparation method of sugarless fritillaria cirrhosa-fructus momordicae granules for relieving cough, which comprises the following steps of: firstly, drying and coarsely crushing traditional Chinese medicines, crushing fritillaria cirrhosa through gas flow, and extracting fructus momordicae, loquat leaves and balloon flower by a semi-bionic extraction method and an ethanol extraction method or a semi-bionic extraction method or an ethanol extraction method and a water extraction method to prepare clear cream; and then, adding fritillaria cirrhosa powder, menthol and auxiliary materials to prepare granules for relieving cough by a conventional method. The granules prepared by the invention solve the problem that the granular traditional Chinese medicine preparation takes sucrose as a flavoring agent which can decompose some medical effective components and can influence absorption, and the granules can meet the requirements of all people for taking the traditional Chinese medicine preparation. The granules are especially suitable for being taken by patients with diabetes, hyperglycemia, hypertension, obesity and the like. By using the method, after the traditional Chinese medicines are coarsely crushed, the contact area between the traditional Chinese medicine powder and a solvent is increased in the extraction process, the extraction time is shortened, the transfer rate is high, the time is saved, the production cycle is shortened, the utilization ratio of the raw materials is improved, and the effective components of the raw medicines are kept.