A method for diagnosing pipeline leakage based on a combined algorithm of big data, which obtains pipeline pressure data, acoustic wave data, and flow data in real time through pressure transmitters, acoustic wave sensors, and flow meters; by connecting the PPS interface of the GPS system with the communication interface, the Synchronously store pressure data, acoustic wave data and flow data; use negative pressure wave method, acoustic wave method, and mass balance method to obtain measurement data, and use neural network algorithm after merging pressure data, acoustic wave data, and flow data at multiple scales Leakage diagnosis, and multiple algorithm diagnosis results are obtained at the same time; the diagnosis results of the above algorithms are combined, and the final diagnosis result is obtained by pattern discrimination with structural risk minimization; the positioning distance of each road is integrated, and the combined algorithm positioning result is obtained through statistical analysis; The technical means of combining multiple inspection methods combines the advantages of multiple algorithms and complements each other, improving the sensitivity of leak detection and the positioning accuracy of leak locations.