The present invention discloses a chromium-molybdenum low-alloy prestress aluminum-cladding steel wire manufacturing method, wherein the chromium-nickel-molybdenum alloy structure steel is adopted as a billet material and comprises, by mass, 0.28-0.38% of carbon, 0-0.35% of silicon, 0-0.90% of manganese, 0.80-1.50% of chromium, 3.00-4.00% of nickel, 0.40-0.60% of molybdenum, 0-0.015%of phosphorus, 0-0.015% of sulfur, 0-2.0 ppm of hydrogen, 0.10-0.20% of vanadium, 0-0.025% of titanium, 0-0.20% of copper, 0-0.05% of aluminum, 0-0.50% of residual elements, and the balance of Fe. According to the chromium-molybdenum low-alloy prestress aluminum-cladding steel wire manufacturing method designed by the present invention, strength and toughness of the steel wire can be substantially increased, a corrosion resistance degree of the steel wire can be enhanced, and a service life can be prolonged.