The invention relates to a tencel/combed long staple cotton/ramie blended yarn and a production method and application thereof. The blended yarn is made of tencel, combed long-staple cotton and ramieaccording to the weight ratio of 45:43:12 through blended spinning. The production method includes the following processes: blowing, cotton carding, drawing, roving, spinning, winding and the like. The final product of the tencel, combed long-staple cotton and ramie blended yarn is a middle-high-count yarn. Fabric prepared by the blended yarn has the characteristics of excellent gloss and excellent wearing performance, and is comfortable and breathable, antibacterial, odor-adsorbing and deodorizing, antiseptic, mildew-resistant and wear-resistant. The production method achieves proportion optimization of tencel, combed long-staple cotton and ramie fiber. And the final yarn has excellent quality indexes, gives full play to the advantages of each fiber, and avoids the shortcomings of each fiber. The final fabric is a high-end shirt fabric with high market value, is popular among consumers, and can bring great benefits for companies.