The invention discloses a heat exchanger with a corrugated pipe coil structure provided with an internal duct and an external duct, which comprises an inlet, an outlet, a corrugated pipe, a dome, an internal ring bushing, an external ring bushing, a fan and a bracket. When fluid media to be in heat exchange flow in the corrugated pipe in the heat exchanger from the inlet, form a turbulent flow ina pipe wall with a corrugated structure and carry out heat exchange with air in the internal duct and the external duct outside the corrugated pipe via the wall of the corrugated pipe, the fan discharges air in the internal duct and the external duct, and the fluid media are discharged from the outlet after the heat exchange performed in the corrugated pipe in a spiral way. The heat exchanger hasthe advantages of high heat exchanger effectiveness, simple structural technology, light weight, integration, and the like, and the fluid media in the pipe coil after the heat exchange have even temperature, thereby the heat exchanger can be used for heat exchange of air, liquid and air-liquid mixing substances. When the corrugated pipe adopts resistant materials, the heat exchanger can be used for heat exchange for corrosive liquid media.