The invention discloses a method and a device for precisely sending a message according to a region. The method comprises the following steps of: 100, collecting signaling data occurring in a mobile network by a mobile user, carrying out preprocessing on the signaling data to generate an original message, and then compounding a call record (CDR); 101, obtaining behavior information of the mobile user from the CDR, meanwhile obtaining the position information of the mobile user when a communication behavior occurs, and finally storing identification information and current position information of the mobile user in a memory in real time; 102, according to position information included in a message distribution area, extracting a user number which appears lately in the region from the memory to generate a message; and 103, submitting a generated message into a message center, and carrying out the sending of the message. By the adoption of the method, the regional precise sending of the message is guaranteed, the mobile user in a regional range is enabled to universally receive the content of the message, and disturbance for a user out of the regional range is prevented.