The invention discloses an antenna switching system of a mobile terminal. The antenna switching system comprises a first antenna, a second antenna, at least one duplexer and a switching unit, wherein the first antenna is arranged on the top of the mobile terminal and is used for transmitting and receiving GPS (Global Positioning System), WIFI (Wireless Fidelity) and BT (Bluetooth) signals, and GSM (Global System for Mobile Communications), WCDMA (Wideband Code Division Multiple Access) and TD-SCDMA (Time Division-Synchronization Code Division Multiple Access) signals of at least a first frequency band; the second antenna is arranged on the bottom of the mobile terminal and is used for transmitting and receiving GSM, WCDMA and TD-SCDMA signals of at least a second frequency band; the duplexer is coupled with the first antenna and is used for separating one or more of the GPS, WIFI, BT, GSM, WCDMA and TD-SCDMA signals; the switching unit is used for selecting the first antenna or the second antenna to work. With the adoption of the manner of the antenna switching system, the influences on the performance of the second antenna when a human body is contacted with the bottom of the mobile terminal are avoided, and user experiences are improved.