The invention discloses a traditional Chinese medicine prescription for increasing a success rate of PICC (Peripherally Inserted Central Catheter) puncturing by expanding a peripheral blood vessel. The traditional Chinese medicine prescription comprises the following components: 1-3 parts of ground beetle, 1-5 parts of panax notoginseng, 2-5 parts of leech, 2-5 parts of lumbricus, 3-5 parts of peach kernel, 3-10 parts of carthamus tinctorius, 3-5 parts of radix aucklandiae, 3-5 parts of radix curcumae, 2-5 parts of cowherb seed, 2-5 parts of cacumen biotae, 2-5 parts of radix clematidis, 2-5 parts of folium ginkgo, 3-5 parts of achyranthes bidentata, 2-5 parts of eucommia, 3-10 parts of ligusticum wallichii, 3-10 parts of caulis spatholobi, 2-5 parts of radix linderae, 1-3 parts of notopterygium root, 1-5 parts of ramulus cinnamomi, 1-3 parts of ramulus mori, 1-2 parts of rosin, 1-3 parts of polygonum cuspidatum, 2-5 parts of flos chrysanthemi indici, 2-5 parts of herba violae, 2-5 parts of salvia miltiorrhiza, 1-5 parts of rhizoma corydalis and 2-5 parts of Chinese angelica. The traditional Chinese medicine prescription lowers the treatment cost, can obviously expand the blood vessel, can reduce mechanical phlebitis caused by a fine blood vessel during puncturing, raises a comfort level of a patient, and has wide clinic popularization significance.