The invention discloses a vacuum-based saline solution heat pump regeneration pump which is composed of a vacuum maintaining mechanism, a water catching cold source cycle, a regenerated heat source cycle, a dilute solution supply mechanism, a condensed water drainage mechanism and a regenerated solution drainage mechanism. The vacuum maintaining mechanism comprises an air cylinder, a piston, a water catcher, a first water retaining gate, a regenerator, a regenerated solution tank, a condensed water tank, a heavy tray, a connection rod, a one-way valve and an electromagnetic valve. The water catching cold source cycle comprises a heat pump unit, a second heat regenerator, an electromagnetic valve and a stop valve. The regenerated heat source cycle comprises a first heat regenerator, an electromagnetic valve and a stop valve. The condensed water drainage mechanism comprises a condensed water tank, a one-way valve, an electromagnetic valve and a second water retaining gate. One heat pump set is adopted as cold and heat sources, two effects are achieved, energy is saved, and the structure is compact. In the drainage aspect of condensed water and a regenerated solution, the condensed water and the regenerated solution can be drained out of the system without pressure difference through the valves and other control.