The invention discloses a live center mechanism of a cabling machine cradle. The mechanism comprises a rack, a shaft, a fixed sleeve, a moving sleeve and a positioning mechanism, the positioning mechanism is used for positioning the moving sleeve, the shaft is arranged on the rack, the moving sleeve is rotatably installed on the shaft, the fixed sleeve is disposed on the outside of the moving sleeve and fixedly connected with the rack, a bearing cap is installed at the left end of the moving sleeve, a second gland is installed at the right end of the moving sleeve, the left end of the shaft penetrates through the bearing cap, a centre is installed at the end of the shaft, the right end of the shaft is located in the moving sleeve, a through hole is disposed at the center of the second gland, an outer hexagonal screw is welded on the through hole, a first screw thread is arranged on an inner circle of the fixed sleeve, a second screw thread which is matched with the first screw thread is arranged on an outer circle of the moving sleeve, and a plurality of positioning grooves which are close to the second gland are uniformly disposed on the periphery of the moving sleeve. The live center mechanism of the cabling machine cradle has the advantages that the structure is compact, the usage and operation are convenient, and problems that loading and unloading of wire coils of existing cabling machines are required to be completed by cooperation of numerous workers, the wire coil replacement is time and effort consuming, the operation procedures are verbose, and the production efficiency is low are solved.