84 results about "Multi focus" patented technology

The invention relates to a super-resolution fluorescence lifetime microscopic imaging method and system based on pixel relocation. The method comprises the following steps: S1, carrying out multi-focus parallel scanning on a sample by using an acousto-optic deflector; s2, synchronously collecting a fluorescence intensity image and fluorescence lifetime data through an area array detector and a point detector; and S3, carrying out super-resolution reconstruction on the fluorescence intensity image based on a pixel relocation algorithm, and mapping fluorescence lifetime data to a reconstructed image to generate a super-resolution fluorescence lifetime microscopic image. According to the invention, an AOD is adopted to replace a scanning galvanometer in a traditional TCSPC-FLIM imaging system as a light beam scanner; addressing scanning of AOD, image acquisition of EMCCD and life data acquisition of PMT and TCSPC cards are closely linked by combining well-designed multiple paths of synchronizing signals, and fluorescence life data are distributed to each dot matrix through a later data processing method, so that organic combination of super-resolution and FLIM can be realized without complicated equipment, and SR-FLIM images of samples are obtained.

The invention discloses an image edge feature enhancement correction fusion method based on a guide filter, and aims to solve the problems that detail features of a low-illumination visible light image and an infrared image are not obvious, focusing edge information is not clear, and registration of a multi-focus image is wrong. The invention provides an edge feature enhancement correction fusion method based on a guide filter. In the illumination enhancement stage, a visible light image is divided into a base layer and a detail layer through a guide filter, and the image contrast and detail information are enhanced. For an infrared image, an infrared background is reconstructed by using a quadtree decomposition and Bezier interpolation method, unclear focusing edge feature information is extracted, and the visibility of image details is enhanced. And finally, reconstructing the two processed images by using a multi-scale weighted gradient method, and performing fusion by calculating large-scale and small-scale weight scales.

The invention discloses a multi-focus time sequence embryo image double-constraint processing method and system, and the method comprises the steps: S410, collecting a multi-focus image sequence through a time-delay imaging technology, and enabling each collection moment to comprise n images of different focus planes; step S420, the RMT16 backbone network respectively processes the n images of different focus planes to obtain n corresponding feature maps, and each feature map represents a prediction result of a corresponding focus plane image; s430, inputting a group of feature maps into a multi-focus consistency head, and comparing the multi-focus consistency head with a real result to obtain consistency loss; inputting the other group of feature maps into a multi-focus contrast head, and comparing internal information of the generated feature maps corresponding to the n plane images with different focuses to obtain contrast loss; and S440, performing weighted summation on the obtained consistency loss and comparison loss to obtain total loss, and updating model parameters according to the total loss.

The invention provides a multi-focus excitation confocal fluorescence microscopic imaging flow cytometry screening method. The method is characterized in that a laser beam generates three laser beams through a spatial light modulator, and the three laser beams are coherently superposed in a focal plane of a microscope objective to generate a two-dimensional optical lattice light field. And after the other laser beam is shaped by the cylindrical lens, linear laser optical tweezers are realized through the microscope objective, cells to be detected in an imaging detection area of the micro-flow chip are captured, and accurate active optical control on the rotation angle of the cells to be detected is realized. In a cell rotation process, a two-dimensional optical lattice light field rapidly scans in a focal plane at different angles, and a fluorophore in the cell is excited to generate a fluorescence signal. The confocal pinhole array installed at the position conjugate with the focal plane eliminates background fluorescence, a high-spatial-resolution fluorescence image of a three-dimensional structure in the cell is obtained, and cell screening is achieved. The method provided by the invention has the characteristics of high detection rate, high accuracy and the like, and has wide application prospects in the research fields of biology, medicine and life science.

The invention discloses a method for generating a multi-focus circular beam based on an all-dielectric metasurface, and the method specifically comprises the following steps: 1, constructing the all-dielectric metasurface which is composed of a plurality of arranged super atoms; the super atom comprises a square SiO2 substrate, and a rectangular Si nanorod is arranged on the SiO2 substrate; and 2, irradiating the all-dielectric metasurface by using left-hand circularly polarized light as incident light, and modulating the incident light by using a geometric phase and a propagation phase, so that emergent light of the all-dielectric metasurface forms a right-hand circularly polarized multi-focus circular light beam. According to the invention, the circularly symmetrical light beams with a plurality of self-focusing focuses can be efficiently and flexibly generated, and the number and the focal depth of the focuses can be adjusted as required.

The present application relates to the technical fields of optical elements, systems, instruments and imaging, and discloses a multi-point confocal image scanning microscope and an imaging method. According to the present application, an imaging light source assembly, a light source collimation assembly, a multi-focus generation assembly, a multi-focus moving assembly, a multi-focus projection assembly, and a camera detection assembly are arranged along a light path, so as to achieve complete image recording. A unique multi-focus illumination mode provided by the present application is used in combination with an optical locked-phase detection technology, so that a defocus-induced stray signal during thick sample imaging can be effectively removed, and depth imaging is performed; the multi-focus generation assembly is switched, so that switching between a wide-field mode, a confocal mode and a super-resolution mode is easily achieved. Moreover, the present application uses a pixel redistribution algorithm to perform super-resolution reconstruction, and uses a multi-image deconvolution reconstruction algorithm and redundant information in a raw data set to perform frame reduction reconstruction, thereby increasing the imaging speed. Compared with the existing methods, the present application can increase the imaging speed, improve the imaging depth, reduce phototoxicity, and widen the diversity of imaging modes.

A multi-focus adjustable lens-based dynamic visual perception training device disclosed by the present invention comprises a rear supporting shell and a mounting shell, the rear supporting shell is connected with the mounting shell through a connecting assembly, two mounting frames are symmetrically and fixedly mounted on the inner wall of the mounting shell, rotating shafts are rotatably mounted in the mounting frames, and the rotating shafts are connected with the rear supporting shell through a connecting assembly. A sliding table is movably mounted between the mounting frames and the rotating shaft, two mounting frames are arranged on the side wall of the sliding table, and two multi-focus inner lenses are arranged at the bottom of the mounting shell; through the combined action of the high-precision stepping motor, the rotating shaft, the sliding table, the first mounting hole and the second mounting hole, the multi-focus inner lens can be mounted at the bottom of the sliding table through the first mounting hole, the second mounting hole and a bolt, the rotating shaft is driven by the high-precision stepping motor to rotate, then the sliding table can be driven to move, and then the multi-focus inner lens is driven to move. Therefore, the total diopter of the superposition of the multi-focus inner lens and the multi-focus outer lens is adaptive to the myopia degree of the child.

Provided herein are methods, systems, and computer program products for image fusion. A first z-stack of images of a biological sample may be received. The first z-stack of images may correspond to a first field of view, which comprises a plurality of patches. A second z-stack of images of the biological sample may be received. The second z-stack may correspond to the first field of view. A focus map may be determined based on the second z-stack, the focus map indicating, for each of a plurality of patches of the first field of view, one of the images of the second z-stack bringing into focus that patch of the first field of view. The focus map may be applied to the first and second z-stacks to generate respective first and second fused images. The first fused image may be subtracted from the second fused image to produce a subtracted image.

The present invention relates to a multi-focus type ultrasonic generator comprising: a casing unit for generating ultrasonic waves; an ultrasonic transducer unit which is mounted on the casing unit for generating ultrasonic waves and which emits ultrasonic waves toward one surface of the casing unit for generating ultrasonic waves; and a multi-focus lens unit which is mounted on one surface of the casing unit for generating ultrasonic waves, and through which the ultrasonic waves generated in the ultrasonic transducer unit pass to form, in the passing ultrasonic waves, at least two ultrasonic focal points having different arrival positions in the skin, and thus, since a plurality of ultrasonic focal points having different arrival positions in the skin are emitted on the skin, treatment time can be significantly reduced and treatment efficiency and a treatment effect can be improved.

The invention relates to the technical field of medical image processing, in particular to an intestinal polyp segmentation method and system based on a spiral scanning state space model, and the method comprises the following steps: S1, obtaining and preprocessing an image; s2, performing multi-scale context feature coding; s3, self-adaptive frequency domain feature enhancement is carried out; s4, performing decoding and segmentation prediction; and S5, carrying out threshold processing to generate a binary segmentation mask image. According to the method, the boundary integrity of an irregular target is kept through a dynamic multi-focus spiral scanning strategy, and the adaptive frequency domain filtering module is introduced to enhance the discriminability of key features, so that the segmentation precision and robustness in complex medical image tasks such as intestinal polyp and the like are comprehensively improved.

The invention provides a multi-focus point ring light spot generation system and a laser welding method, and belongs to the technical field of laser machining. The system comprises an annular light source, a first collimating lens, an annular light beam generation module and a first reflecting mirror which are sequentially arranged at intervals along a first linear direction, and a point light source, a second collimating lens, a first focusing mirror, a multi-curvature hollow reflecting mirror and a second focusing mirror which are sequentially arranged at intervals along a second linear direction, the center of the multi-curvature hollow reflecting mirror and the center of the second focusing mirror are provided with through holes for light beams emitted by the point light source to penetrate through, and the mirror surface curvature of the multi-curvature hollow reflecting mirror is adjustable. The technical problems of high processing cost and poor deep welding stability caused by structural limitation of a point ring laser in the prior art can be solved.

The invention provides a real-time multi-focus image fusion method and system based on an FPGA, and relates to the technical field of image processing, and the method comprises the steps: collecting binocular images with different focal lengths, and carrying out the preprocessing of the binocular images; extracting feature points of the binocular image through a scale invariant feature transformation algorithm; calculating gradient direction distribution information of a surrounding area of the feature point through a gradient function, and determining a main direction of the feature point; calculating a gradient modulus and a gradient direction in a neighborhood of each feature point, and rotating a neighborhood region according to a main direction of the feature point to generate a descriptor; the similarity between the feature descriptors is calculated through the Manhattan distance, feature point matching is carried out, and then the matching relation of the images is determined; and splicing the registered images to obtain a fused image. According to the method, the feature points with invariance in scale, rotation and illumination change in the binocular image are extracted through the scale invariant feature transformation algorithm in combination with the gradient function, and the perception and decision-making performance of the system in a complex dynamic environment is remarkably improved.

The invention provides a high-precision infrared fault detection method, which comprises the steps of setting a plurality of focus positions under each response rate, and collecting data of a preset frame number in a focusing process of each focus position; the data comprises temperature data and image data; processing the acquired image data by using a multi-frame super-resolution reconstruction network, a multi-focus fusion network and a multi-response-rate fusion network to obtain a reconstructed infrared image; and fault detection is realized through a fault diagnosis network by using the reconstructed infrared image and historical temperature data. According to the invention, through multi-frame, multi-focus and multi-response-rate image fusion, high-resolution and high-dynamic-range clear imaging and accurate temperature measurement are realized; by using historical temperature data and a reconstructed infrared image, spatial features and time sequence features are aligned and fused, and intelligent thermal fault diagnosis of industrial equipment is realized.

In at least one embodiment a camera system includes a multi-focus lens, an image sensor and an image processor. The multi-focus lens has a first focal length and a second focal length. The image processor is arranged downstream of the multi-focus lens. In operation, the image sensor generates a combined image according to the first and second focal lengths of the multi-focus lens. The image processor receives the combined image and separates the combined image into a first image of the first focal length and a second image of the second focal length.

The application discloses a kind of optical lens centering positioning device and method based on multi-focus ring zone lens, the device is by autocollimator, multi-focus ring zone lens, precision five-dimensional adjusting frame, lens group to be measured, mirror seat, leveling centering device, air bearing, displacement sensor, marble frame, image display system, centering positioning measurement analysis system composition, mirror seat is installed on the centering leveling device of air bearing, and through displacement sensor to the center axis of mirror seat and the center axis of air bearing coincide, the spherical center of lens upper surface is located in the focal point of multi-focus ring zone lens, without adjusting the position of multi-focus ring zone lens, the high-precision lens can be quickly centered, and the assembling and adjusting time of lens is greatly reduced;The edge spread function of cross differentiation silk is analyzed by image processing and display system, so as to calculate the axial assembly error of lens, the application solves the problems of low optical lens centering positioning precision and low assembly efficiency.

The invention discloses a high-frequency focused ultrasonic transducer for photoacoustic / ultrasonic endoscopic dual-mode imaging and a manufacturing method of the high-frequency focused ultrasonic transducer. The transducer comprises an acoustic matching layer, a positive electrode, a wafer, a negative electrode, a backing sound absorption material, a substrate and a lead. According to the invention, the wafer is composed of a plurality of same or different units and can generate ultrasonic waves with one or more frequencies, and the wafer and the substrate are jointly processed by a self-focusing hot-pressing process, so that each unit keeps consistent curvature, and single-focus or multi-focus focusing of a sound field is realized; meanwhile, the wafer does not need to be punched, holing is carried out on the substrate, and the integrity of the wafer can be kept. The ultrasonic transducer designed by the invention has a miniaturized structure, a uniform sound wave conduction path and a stable sound field with one or more frequencies, has high durability and reliability, and can effectively improve the imaging quality.

The utility model relates to the technical field of semiconductor light emitting, and discloses a multi-focus light source device which comprises a substrate, a lens and a light emitting chip. The lens is arranged on the substrate, and a cavity structure is arranged between the lens and the substrate. The light-emitting chip is arranged on the substrate and in the cavity structure. The light-emitting chips at least comprise a first light-emitting chip and a second light-emitting chip. The lens is a convex lens, light emitted by the first light-emitting chip and light emitted by the second light-emitting chip are acted by the lens, a first focus area and a second focus area are formed on the side, away from the light-emitting chips, of the lens respectively, the image distances from the first focus area to the lens and from the second focus area to the lens are v1 and v2 respectively, and v1gt is met; v2. According to the utility model, at least two focus areas are arranged, and the double focus areas are staggered front and back. When the lens is heated to expand, the response area is located in the second focus area; when the lens is cooled and shrunk, the response area is located in the first focus area, the energy of the response area can meet the test requirement no matter how the temperature changes, and accurate test and high stability are achieved. The production process is simple, and the production cost is low.

Embodiments of a dermatological cosmetic treatment and imaging system and method can include use of transducer to simultaneously or substantially simultaneously produce multiple cosmetic treatment zones in tissue. The system can include a hand wand, a removable transducer module, a control module, and / or graphical user interface. In some embodiments, the cosmetic treatment system may be used in cosmetic procedures, including brow lifts, fat reduction, sweat reduction, and treatment of the décolletage. Skin tightening, lifting and amelioration of wrinkles and stretch marks are provided.

The invention relates to the technical field of optical microscopy, in particular to a device for realizing high-flux fluorescence detection based on galvanometer scanning, and the device comprises an illumination module which is used for generating a multi-focus plane illumination light beam; the multi-focus plane illumination light beam can enter a first surface of the galvanometer through the dichroscope, and the galvanometer can reflect the multi-focus plane illumination light beam to the objective lens module, so that the multi-focus plane illumination light beam is focused on a sample through the objective lens module to form multi-point illumination; emitted light emitted by a sample through excitation is collected by the objective lens module, then enters a first surface of the galvanometer and is reflected to the dichroscope, the dichroscope can reflect the emitted light to the detection module, signal light enters a second surface of the galvanometer and then can be reflected to the image acquisition module, and the image acquisition module is used for acquiring and imaging the signal light. The method has the effect of solving the technical problems that the existing fluorescence detection speed and resolution are difficult to consider and the resolution improvement of a high-throughput scheme is limited.

The invention relates to the technical field of X-ray imaging, and discloses a tomography device and method based on a multi-focus X-ray source, and the device comprises a control system which is used for controlling the multi-focus X-ray source to carry out the longitudinal scanning of a detected object; n ray tubes which are transversely distributed are arranged on the multi-focus X-ray source, each ray tube internally comprises an independent cathode and an independent anode, and the cathode and the anode are used for triggering and generating multi-view X-rays; the detector is used for receiving the X-rays penetrating through the detected object and converting the X-rays into multi-view projection data; and the image processing system is connected with the detector and is used for processing the multi-view projection data based on a tomography reconstruction algorithm to obtain tomography data of the detected object and a three-dimensional reconstruction model. The multi-focus ray source and the detector which are horizontally and transversely arranged synchronously move for scanning, multi-view-angle and high-efficiency whole-body tomography data acquisition is achieved, and the requirement for rapid, accurate and whole-body tomography imaging is met in combination with a tomography reconstruction algorithm.

A multi-focal ophthalmic lens using suppressed diffraction orders. A multi-focal ophthalmic lens includes an ophthalmic lens and a diffractive element. The ophthalmic lens has a base curvature corresponding to a base power. The diffractive element produces constructive interference in at least four consecutive diffraction orders corresponding to a range of vision between near vision and distance vision. The constructive interference produces a near focus point, a distance focus point, and an intermediate focus point between the near focus point and the distance focus point corresponding to the base power of the ophthalmic lens. The diffraction efficiency of at least one of the diffraction orders is suppressed to less than 10%.

An information handling system camera that includes a rapid focus capability for near and far objects by selectively inserting and removing a refractive material between the camera lens and image sensor to effectively adjust the camera focusing distance. When far object focus is desired, a refractive material of predefined properties is inserted to enable an instant focus of the far object to the image sensor. When a near object focus is desired, the refractive material is removed (or replaced with a thinner material) to rapidly achieve focus. In addition, a voice coil motor or other actuator fine tunes the focus when desired. In one alternative embodiment, focus is performed only with the insertion and retraction of the refractive material so that no lens actuator is included in the camera. The refractive material extends the back focal distance between the lens and image sensor relative to the back focal distance without the refractive material. Rapid insertion of refractive material shortens the time to adjust focus relative to focus time associated with actuator-based lens movement focus.

The present invention provides a method, system, and terminal for super-resolution microscopy of arbitrary curved surfaces, specifically relating to the field of optical microscopy. Based on a wide-field fluorescence image of a target sample, this solution obtains the size and position coordinates of the circumscribed rectangle of a region of interest (ROI), generating a series of multi-focus 2D scanning dot arrays corresponding to the ROI. Based on the structural characteristics of the target sample, an axial coordinate is assigned to each scanning point in the multi-focus 2D scanning dot array, generating a series of 3D scanning dot arrays matching the selected surface template and converting them into a series of 2D dot array fluorescence images. The 2D dot array fluorescence images are then reconstructed to obtain a 3D super-resolution image of each ROI. This solution enables rapid, dynamic 3D super-resolution imaging of any curved surface within any ROI, without being limited by depth of field.

The invention discloses a multi-focus confocal Raman spectrum imager based on field-of-view modulation. An incident laser beam is modulated and split into a plurality of sub laser beams with specific field-of-view angles through a laser light path module; the sub-laser beams are focused by an objective lens to form a multi-focus laser array on the surface of a sample; a sub Raman spectrum excited by each laser focus returns along an original light path, passes through the coupling beam splitter and then is guided to the spectrum acquisition and transmission module; a confocal array pinhole of the spectrum acquisition and transmission module is conjugated with a multi-focus laser array on the surface of a sample, and an optical fiber array fiber core is conjugated with the confocal array pinhole; the returned sub Raman spectrums are subjected to spatial filtering through a confocal array pinhole, are respectively coupled into corresponding optical fiber cores, and are transmitted to a spectrum analysis unit for synchronous detection of laser Raman spectrums of all focuses. By adopting the technical scheme of the invention, multi-focus confocal Raman spectrum synchronous detection is realized, the Raman spectrum signal intensity of each focus is guaranteed, and the Raman spectrum acquisition and imaging speed is improved.

The present invention relates to an algorithm for acquiring light field information by analyzing images of multiple focal points and a measurement structure thereof. A method for acquiring a light field using an optical system according to an embodiment of the present invention may include a step in which, when it is assumed that each of images measured at multiple focal points measures light rays or light fields starting from a specific position, predicted images are generated using the images of multiple focal points, only components that are always at the same position and of the same brightness are compared and extracted from the predicted images generated using the images of the multiple focal points, and a light field including only light rays starting from the specific position is acquired using only the components that are always at the same position and of the same brightness, and obtained as a result of the extraction.

The invention is applied to the technical field of optical microscopic imaging, and discloses a two-dimensional multi-focus optical resolution photoacoustic microscopic imaging system and an imaging method. The system comprises a laser, a lens assembly, a filtering pinhole, a reflector assembly, an optical diffraction element, a focusing lens, a self-made 3D scanner, an acoustic coding mask, a plane focusing ultrasonic transducer, an amplifier, a data acquisition card, a signal generator and an imaging processing terminal. According to the two-dimensional multi-focus optical resolution photoacoustic microscopic imaging system, a laser device outputs a laser beam, and the laser beam is projected to a subsequent optical diffraction element after being subjected to beam expanding by a beam expanding unit composed of a pair of plano-convex lenses and spatial filtering processing of a pinhole in sequence; and the imaging processing terminal obtains the digital photoacoustic signal and processes the digital photoacoustic signal to obtain an imaging image of the sample, so that the purpose of providing a solution for rapid OR-PAM in an economical and efficient manner is achieved, and the speed limitation caused by the laser repetition rate is broken.

Accommodating (re-focusable) lens system that includes multiple elastically-deformable lenslets sequentially disposed along an optical axis and that has an optical power that is varied by changing the degree of applanation of an area of contact between the constituent lenslets in response to variation of force applied to the lenses axially by an external element connected with or forming a part of the lens system housing and / or lenslet support element. Method for operating the same in a manner that reduces optical wavefront errors introduced by the process of refocusing thereby improving imaging characteristics of the lens system.

Embodiments of a dermatological cosmetic treatment and / or imaging system and method adapted to alter placement and position of multiple (e.g., two or more) cosmetic treatment zones in tissue from ultrasound beams from a transducer, simultaneous multi-focus therapy at multiple depths, and / or dithering ultrasound beams from a transducer to alter placement and position of multiple cosmetic treatment zones in tissue. The system can include a hand wand, a removable transducer module, and a control module. In some embodiments, the cosmetic treatment system may be used in various cosmetic procedures.

The invention relates to a spectrum detection device and method based on a multi-focus hollow focusing spot, and the method comprises the steps: enabling a laser beam emitted by a laser to be converted into a flat-topped beam through a beam shaper, and enabling the flat-topped beam to enter a first polarization modulation module through a first beam splitter prism, and converting the flat-topped beam into linearly polarized light; the linearly polarized light enters the spatial light modulator to be modulated into linearly polarized light with a vortex phase, and the linearly polarized light returns along the original path and is reflected by the first beam splitter prism, and then enters the second polarization modulation module to be converted into circularly polarized light with a vortex phase; circularly polarized light passes through the fly eye lens to form multi-focus hollow light spots which are distributed in a ring shape, passes through the focusing lens to form multi-focus hollow focusing light spots which are distributed in a ring shape and act on a plurality of to-be-detected object samples corresponding to the multi-focus hollow focusing light spots in position, various Raman scattering light is correspondingly generated, spectrum analysis is carried out on the Raman scattering light, and the Raman scattering light is analyzed to obtain the Raman spectrum of the to-be-detected object samples. And obtaining various types of spectral information. According to the invention, multi-focus parallel signal detection and acquisition are realized, and compared with a traditional single-point system, the analysis flux is greatly improved.

The application relates to the technical field of precision part detection, and discloses a precision part defect intelligent detection method based on deep learning. A multi-focus image sequence of a part surface is acquired, a multi-scale feature map set is generated through pyramid multi-scale decomposition, defect edge and texture information is extracted, a defect candidate region is determined, the feature map set is fused in combination with an attention mechanism, enhanced defect feature representation is generated, defect projection coordinates are extracted and depth values are calculated, a three-dimensional space position of the defect is acquired, a part surface geometric model is reconstructed, and a defect boundary curve is extracted, the defect width is calculated based on the boundary curve, an abnormal width section is identified and the defect change is tracked, the defect stability is judged, the image acquisition parameters are adjusted according to the defect stability, and optimized multi-focus image sequence acquisition is realized. The application realizes full-process intelligent detection of surface cracks from feature extraction, three-dimensional positioning to dynamic tracking, and significantly improves the detection precision and reliability.