The invention discloses a low-temperature-coefficient variable gain amplifier for enlarging the gain change range. The low-temperature-coefficient variable gain amplifier for enlarging the gain change range comprises a variable gain circuit, a cross coupling temperature compensation circuit and a gain control circuit, wherein the variable gain circuit adjusts the circuit gain according to the intensity of an input signal to stabilize the output power, a negative resistor is adopted to serve as a source electrode degeneration resistor to form positive feedback to improve the transconductance current efficiency of the input transconductance level, a transistor pair connected with a diode and a transistor pair connected with a cross coupler form an active load, under the condition of different-mode signals, a cross coupler pair serves as a negative conductor to reduce the overall conductance of the load, the common-mode gain of the circuit is very low, the cross coupler pair not only improves the gain of the circuit, but also improves the common-mode rejection capacity of the circuit, and meanwhile the cross coupler pair and a reference source with the positive temperature characteristic form the temperature compensation circuit to compensate for the gain range changes of the variable gain circuit caused by temperature changes. The low-temperature-coefficient variable gain amplifier for enlarging the gain change range has the advantages of being large in single-level gain adjusting range, resistant to technological changes, resistant to temperature changes, low in energy consumption and the like.