30 results about "Tissue diagnosis" patented technology

An apparatus and method according to the invention combine more than one optical modality (spectroscopic method), including but not limited to fluorescence, absorption, reflectance, polarization anisotropy, and phase modulation, to decouple morphological and biochemical changes associated with tissue changes due to disease, and thus to provide an accurate diagnosis of the tissue condition.

A tissue guidance system integrates an ultrasound imaging device with a tissue diagnostic probe. Ultrasound imaging is used to guide the tissue probe to the target area. Measurements made by the probe can then be analyzed to determine tissue type or state (e.g., malignant or benign).

A miniature electrode array is utilized to stimulate tissue and measure tissue response. When the tissue response is used to diagnose tissue, the spacing of the electrodes in the array is approximately equal to the depth of tissue which is to be examined. The manufacture of such arrays can be accomplished by embedding printed circuit boards, for example, into a properly shaped probe tip. A kinetic device to position the probe on the surface of the tissue provides location information which is correlated with the simultaneous electrical response data in order to generate a tissue map. The tissue mapping capability can be combined with tissue removal devices in order to direct the excision of tissue. When the tissue response is used simply to determine that the array is in contact with the tissue, the electrodes can be widely spaced. Combined with a cell collection device, the electrodes provide feedback to the practitioner that the collection device is making proper contact over the region where cells are to be collected.

A system for treating breast tissue includes a cannula having a proximal end, a distal end, and a lumen extending between the proximal and distal ends, the distal end configured for insertion into a breast duct such that the lumen is in fluid communication with the breast duct, and a tissue diagnostic device disposed within the lumen. A system for treating breast tissue includes a cannula having a proximal end, a distal end, and a lumen extending between the proximal and distal ends, the distal end configured for insertion into a breast duct such that the lumen is in fluid communication with the breast duct, an imaging device for providing imaging functionality to the cannula, and an energy delivery device secured to, or slidably disposed within the lumen of, the cannula.

A device and method for safely securing a multilumen device to a tissue, organ or solid tumor within the body of a human during a diagnostic or therapeutic procedure is described. The device is capable of securing the tumor by touching or piercing its surface and providing a coolant to the distal tip. Cooling the tip forms a cryogenically induced region that tightly binds the tip to the tumor, temporarily sealing the entry-track of the instrument. The device further provides at least one injecting/aspirating lumen that can dispense or aspirate a fluid within the tumor. Such construction allows injecting part or whole volume of the tumor while the cryogenically induced bond prevents back-flow of the injected substances through the entry-track.

A method using a prior art hand-held device known as the Dolphin Neurostim™ to supply minute, concentrated micro-current impulses to the (outside) perimeters of scar tissue for the purpose of tissue diagnosis (through ohm resistance measurement), promotion of scar tissue repair (through electrical repolarization), and pain management (through sympathetic deregulation of the Autonomic Nervous System. The micro-current stimulus (therapy) is delivered through a tiny metallic spring tip (probe) ideally suited for location (detection) of specific treatment points (which have the cellular characteristic and lowered skin resistance). The device is activated to deliver a concentrated (DC) micro-current stimulus through the scar/suture tissue to another identical device located (mirrored) on the opposing side of the scar/suture. This stimulation reactivates cellular metabolism and membrane exchange, changing scars appearance, softening scar/suture tissue by releasing relating adhesions which re-balances the autonomic nervous system.

The invention relates to the technical field of optical fiber sensing medical devices, in particular to an OCT imaging system for integrated optical fiber sensing in-vivo multi-parameter measurement.The OCT imaging system includes a light source module, a first coupler, a first annular device, an interference module, a special-shaped optical fiber microprobe, a photoelectric detector and a balance detector. Two output ports of the first coupler are connected with an input end of the interference module and a port A of the first annular device respectively; the special-shaped optical fiber microprobe is connected with an interference arm of the interference module and a port B of the first annular device through sector-shaped optical fiber bundles separately; the balance detector is connected with the interference module and a data processing module separately, and the photoelectric detector is connected with a port C of the first annular device and the data processing module separately. The OCT imaging system is reasonable in structure, the OCT probe is integrated with an FBG temperature sensing optical grating and an F-P pressure sensing unit, and the temperature, pressure and other parameters of body tissue are measured at the same time. Precise observation of the shape of the tissue and high-resolution large-scale imaging are achieved, and a significant meaning is achievedon in-vivo tissue diagnoses and the like.

A device for real-time tissue diagnosis of biological tissue having: a means for preparing a tissue sample before a measurement procedure; a means for positioning an ATR element and mirrors so as to perform a system calibration; a means for irradiating a sample with IR radiation using the ATR element and an opto-mechanical assembly; a means for recording the absorption spectrum of a sample being tested; a means for carrying out a Fourier transformation of the absorption spectrum obtained into a FT-IR spectrum; a means for calculating tissue characteristics on the basis of signal processing; a means for comparing the characteristics in a pre-selected wavenumber range with the reference spectra prepared and stored in a database. Also, a method for real-time tissue diagnosis of biological tissue having solely the following steps: setting operating parameters: scanning ambient background air to obtain a background spectrum; placing a tissue under test in tight contact with an ATR; drying the tissue so as to at least reduce moisture content of the tissue sample; automatically adjusting at least one system mirror thereby performing a system calibration; and obtaining a spectrum of the tissue sample.

The invention relates to the technical field of gene diagnosis, in particular to an in-situ nucleic acid diagnosis and detection system for BKV. The in-situ nucleic acid diagnosis and detection systemcomprises probes used for detecting the BKV, sequences of the probes are the sequences or complementary chains correspondingly shown in SEQ ID NO: 1-40. The invention further discloses application ofthe in-situ nucleic acid diagnosis and detection system to preparation of diagnosis or detection reagents/kits for the BKV. The tissue hybridization in situ diagnosis and detection system for the BKVis high in sensitivity and good in specificity, and can be used for accurately diagnosing the activation of the BKV to guide clinical symptomatic medication, and the sensitivity and specificity of the BKV tissue diagnosis are improved. According to the application of the BKV hybridization in situ technology, the sensitivity and specificity of the BKV tissue diagnosis can be greatly improved, theharm caused by BKV related diseases is reduced, and wide market application prospects are achieved.

Provided is a method of obtaining an index value used for pathological tissue diagnosis of prostate cancer, which method has low invasiveness and can be performed at a low cost. The method is a method of estimating a Gleason score that represents the malignancy of prostate cancer, which method includes: measuring the content of a prostate-specific antigen having an N-acetylgalactosamine residue at a non-reducing terminal of a sugar chain in a sample; and estimating that the Gleason score is 7 or higher when the thus measured value is larger than a threshold value, or estimating that the Gleason score is 6 or lower when the measured value is smaller than a threshold value. The prostate-specific antigen is preferably quantified by a method including the step of binding a molecule having an affinity for β-N-acetylgalactosamine residue, such as Wisteria floribunda lectin, soybean agglutinin, Vicia Villosa lectin or an anti-β-N-acetylgalactosamine antibody, to the prostate-specific antigen.

The invention discloses a pancreatic cancer detection kit. The kit comprises a PCR reaction solution, polymerase, a negative control sample and a positive control sample, wherein the PCR reaction solution comprises dNTPs, PCR Buffer, a primer and a probe, the volume and the quantity of the raw materials are 0.96 mL x 2 parts respectively, the polymerase is Taq DNA polymerase, and the volume and the quantity of the raw materials are 85 [mu]l x 1 part respectively. The invention relates to the technical field of gene engineering. According to the pancreatic cancer detection kit and the detectionmethod (PCR method), pancreatic non-cancerous tissue and cancerous tissue can be distinguished through a DNA methylation state, the sensitivity and specificity of cancer tissue diagnosis are both 100%, and it can be found as soon as possible that secreted protein acidic and rich in cysteine (SPARC) of a recurrent patient plays a role in regulating the cell matrix effect and tumor angiogenesis, proliferation and migration. SPARC gene methylation occurs in the early stage of pancreatic cancer, so that detection of SPARC gene methylation is of great significance to early diagnosis of adenocarcinoma.

The invention discloses an application of a tuberculosis immunohistochemical kit in diagnosis of tuberculosis pathological tissue (including intrapulmonary and extrapulmonary tuberculosis pathologicaltissues), and belongs to the field of tuberculosis diagnosis. According to the invention, a tuberculosis antigen specific aptamer nucleic acid antibody is adopted, biotin, or fluorescence, chemiluminiscence and the like are adopted for labeling, mycobacterium tuberculosis specific antigen (ManLAM antigen) existing in tuberculosis pathological tissues is detected, and the antigen can exist in thalli and be secreted to the surrounding space; clinical sample immunohistochemistry proves that the tuberculosis antigen specific aptamer antibody is high in staining on tuberculosis infected tissues and low in background staining. The tuberculosis is tuberculosis caused by mycobacterium tuberculosis or drug-resistant mycobacterium tuberculosis (including intrapulmonary tuberculosis and extrapulmonary tuberculosis) and all tuberculosis co-affected by people and livestock. The invention provides a tuberculosis immunohistochemical kit in tuberculosis pathological tissues, and provides a new tool for histopathological definite diagnosis of tuberculosis pathological tissues.

A method of using of a pair of prior art hand-held device known as the Dolphin Neurostim™ to supply minute, concentrated micro-current impulses to the perimeters of cranial sutures for the purpose of tissue diagnosis (through ohm resistance measurement), promotion pain management (through sympathetic deregulation of the Autonomic Nervous System. The micro-current stimulus (therapy) is delivered through a tiny metallic spring tip (probe) ideally suited for location (detection) of specific treatment points (which have the cellular characteristic of lowered skin resistance). The device concurrently detects, measures, and stimulates therapeutically active treatment points located beside sutures. Once detected, the device is activated to deliver a concentrated (DC) micro-current stimulus through the suture tissue to another identical device located (mirrored) on the opposing side of the suture. This unique stimulation when applied as described in this invention re-balances the autonomic and central nervous systems.

A method for diagnosing the probability of the onset of glaucoma or the degree of the advancement of glaucoma by observing connective tissue of lamina cribrosa and its neighboring part of retina, namely the movable nature of lamina cribrosa in relation to retina.