The invention relates to sealing equipment, in particular to medicine barrel sealing equipment used for the pharmacy department. The medicine barrel sealing equipment, capable of automatic feeding, automatic sealing and automatic film replacing, used for the pharmacy department is provided. The medicine barrel sealing equipment used for the pharmacy department comprises a baseboard, stopping blocks and oblique blocks, wherein the two stopping blocks are arranged on the baseboard, the two oblique blocks are arranged on the baseboard, a film-laminating sealing mechanism is arranged on the baseboard, and a manual downward-pressing mechanism is arranged on the film-laminating sealing mechanism. According to the medicine barrel sealing equipment used for the pharmacy department, by arranging a transfer mechanism, the transfer mechanism runs to drive a pushing mechanism and a clamping mechanism to run, the pushing mechanism runs to make the manual downward-pressing mechanism run, the clamping mechanism drives medicine barrels to move rearwards, the medicine barrels are sealed by the manual downward-pressing mechanism, thus effects of automatic feeding and automatic sealing are achieved, by arranging an automatic take-up mechanism, an automatic downward-pressing mechanism runs to drive the automatic take-up mechanism to run, and thus sealing films are updated, so that an effect of automatically updating the sealing films is achieved.