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The application discloses a cell culture shaking device convenient to adjust, and relates to the technical field of cell culture.The cell culture shaking device convenient to adjust comprises a shaking plate, the shaking plate is obliquely arranged in a shell, a plurality of holes are formed in the surface of the shaking plate, a limiting assembly is fixedly connected to the inner side surface of the shaking plate, a driving assembly is fixedly connected to the bottom of the inner side surface of the shell, the side of the driving assembly close to an end cover is in surface spline connection with the limiting assembly, and a clamping assembly is fixedly connected to the inner wall of the hole of the shaking plate.Because the shaking plate is obliquely arranged, the culture bottle not only generates horizontal circular motion in the rotating process, but also generates up-down displacement along the inclined surface of the shaking plate.In the process of revolving around the driving assembly once, the culture bottle will experience a complete rising and falling process, three-dimensional composite oscillation effect is formed, the culture medium and the culture bottle generate complex relative movement, cell and nutrient substance contact can be more efficiently promoted, and gas exchange efficiency is enhanced.