The invention discloses a waste collection and nursing device in operating room nursing, in particular to the field of operating room nursing. The waste collection and nursing device comprises a storage box, a telescopic slot is arranged at the top of the storage box, an electric telescopic rod is fixedly connected to the inner cavity of the telescopic slot, the end of a piston rod of the electrictelescopic rod is fixedly connected with a box cover, a middle of the storage box is provided with a separating mechanism, and the bottom of the inner side of the storage box is provided with a screening mechanism. The invention provides the separate mechanism, so that a forward and reverse motor drives a rotating plate to rotate, so that the garbage passing through holes is dropped to the two ends of the inner cavity of the storage box, thereby realizing the separate separation of the liquid garbage, at the same time, by setting the screening mechanism in the inner cavity of the storage box,the garbage on the surface of a partition plate is detected by a humidity sensor, a first cylinder and a second cylinder work together to push the solid waste and the solid-liquid mixed garbage intotwo different collection boxes for collection, and the classification of the garbage can be realized.