The invention discloses a packaging module, a preparation method thereof, a base station and electronic equipment. The packaging module comprises a substrate, a chip located on the substrate, a first plastic packaging layer, a wiring layer located on the plastic packaging layer, and a plurality of interconnection electrodes, a second plastic packaging layer and a conductive layer which are located on the wiring layer. The interconnection electrodes are electrically connected with the wiring layer, and the conductive layer is located on the second plastic packaging layer and comprises a grounding welding pad and a signal transmission welding pad electrically connected with the plurality of interconnection electrodes. In the packaging module, the interconnection electrodes can adjust the height of the cavity, so that the self-excitation problem of the power amplifier can be avoided. And the grounding welding pad in the conductive layer can shield the radio frequency signal on the wiring layer, so that the signal interference problem between the chip and the power amplification plate can be improved. Besides, as only the signal transmission welding pad for providing input/output signals for the chip needs to be arranged in the conducting layer, and wiring does not need to be arranged, enough area can be provided for arranging the grounding welding pad, and the occupied area of the packaging module can not be increased.