The invention discloses a bulk concentrate flotation separation method based on reinforcement of lead sulfide inhibition. Firstly, wet process pretreatment is conducted on the bulk concentrate, the inhibition to lead sulfide in the bulk concentrate is selectively reinforced, then sulfuric acid or a mixture of the sulfuric acid and manganese dioxide and a mixture of sulfuric acid and ammonium persulfate is added, filtration is performed after heating and stirring, filtrate can be recycled, a filter cake is washed till pH is close to the neutral, then water is added for size mixing, then terpenic oil is used as a foaming agent, and the flotation separation is performed by adopting the flotation process of rough flotation, fine flotation and re-flotation of middlings. The method based on theprocess of separating lead and other ingredients in vulcanized bulk concentrate has the advantages that the steps complement each other's advantages, agent preparation is simple, copper-lead or lead-zinc separation is thorough, the cost is low and the recovery rate is high, is applied to copper-lead, lead-zinc or copper-lead-zinc bulk concentrates, achieves economic and efficient copper-lead and lead-zinc separation of copper-lead or lead-zinc vulcanized bulk concentrates, remarkably improves the utilization rate of copper, lead and zinc resources and is good in effect.