The invention discloses a small differential high-voltage output relay structure. The relay control box includes a bottom plate, a side plate, a cover plate and a wiring board assembly; the bottom plate in the side plate is provided with a circuit board support and a relay support , the circuit board bracket is connected with a control circuit board, and the relay bracket is connected with a relay; the circuit of the control circuit board includes an input power supply, a three-terminal voltage regulator circuit, a differential drive circuit, a spike suppression circuit, and a control signal anti-shake circuit , Relay drive circuit, power output circuit and status indication circuit. The present invention has the advantages of small size, light weight, strong load capacity, excellent reliability, high insulation resistance, good environmental adaptability, difficult signal attenuation, strong anti-interference ability, low power consumption, strong reliability, and easy implementation of RS485, RS232, RS422, CAN, CC‑LINK bus remote control, accurate control, sensitive action, compatible with computer digital control system, and strong environmental adaptability.