The invention discloses a high-rise escape slide. The high-rise escape slide comprises a slide body and a steel rail, steering ladders are welded to the two ends of the slide body, a plurality of grooves are formed in the surfaces of the top ends of the steering ladders, a pair of holes are formed in the two sides of the inner wall of each groove, miniature carrier rollers are connected between the holes in a clamped mode, and frosted pieces are installed at the joints of the miniature carrier rollers and the grooves. First sliding rails are arranged at the top end and the bottom end of the steel rail, the steel rail is movably connected with calipers through the first sliding rails, bearings are embedded in the two ends of the calipers, the calipers are movably connected with pulleys through the bearings, movable shafts are connected to the two sides of the pulleys, elastic telescopic piles are connected to the outer walls of the movable shafts, and check blocks are connected to one ends of the elastic telescopic piles. A plurality of baffles are installed on the inner walls, close to the check blocks, of the calipers, the calipers comprise handles, rotating shafts, clamping corners and buttons, and a pair of rotating shafts is installed on one sides of the handles. The high-rise escape slide is simple and reasonable in structure, novel in design, capable of effectively improving safety, easy and convenient to operate and high in practical value.