The invention discloses a blowing, filling and sealing integrated machine for a plastic ampoule, which comprises a machine frame, and an extrusion bottle making device, a filling and sealing device and a die cutting device which are sequentially arranged according to procedures in the horizontal direction, a filling and sealing positioning component is arranged below a filling and sealing stationon the filling and sealing device, the extrusion bottle making device is connected with the filling and sealing device through a first conveying component so as to accomplish the conveying to bottle clamps, the filling and sealing device is connected with the die cutting device through a second conveying component so as to accomplish the conveying to the bottle clamps after filling and sealing, and a slot cutting component is mounted on the die cutting device. The blowing, filling and sealing integrated machine disclosed by the invention has the advantages of simple and compact structure, lowcost, small occupied area, short material conveying time, convenience and fastness in positioning, and easiness in control and debugging, and the like.