The utility model discloses an isolation disinfection device which comprises a flow guide shell, an
air cavity is formed in the flow guide shell, an air inlet is formed in the top of the flow guide shell, an air outlet is formed in the bottom of the flow guide shell, the air outlet inclines towards the ground and is annular, and an air blowing
assembly is arranged in the middle of the
air cavity; an isolation space formed by high-speed
airflow blowing downwards can be formed, and the interior and the periphery of the space are killed while the isolation space is formed; after the isolation disinfecting and killing device is started, when a patient is located in the isolation space, due to the existence of the isolation space formed by high-speed
airflow, infectious substances such as viruses,
bacteria and unclean suspended matters in the air on the outer side of the isolation space can be isolated at the periphery of the space by the high-speed
airflow and are disinfected and killed; therefore, the patient in the isolation space cannot be in contact with infectious substances when in the isolation space, and the risk of mutual infection is reduced.