34 results about "Electron tomography" patented technology

A manufacturing method for an electron tomography specimen with embedded fiducial markers includes the following steps. A chip of wafer is provided. The chip includes at least one inspecting area. At least one trench is produced beside the inspecting area. A liquid with the markers is filled into the trenches. A first protection layer is coated on the chip, and then a second protection layer is deposited on the first protection layer. Therefore, the markers can be embedded into the electron tomography specimen. The embedded markers can improve the alignment process, due to those embedded markers are easily tracked during feature tracking procedure. In addition, our novel invention also successfully provides a modified version of the technique to deposit gold beads onto TEM pillar samples for much improved 3D reconstruction.

A Compressed Sensing (CS) based image reconstruction method and system is described herein which may be used to reduce the X-ray dose radiation in Computed Tomography (CT) or to decrease the scan duration in MR imaging (MRI). Methods and systems described herein may address problems that have hindered the clinical usage of CS, i.e. computation complexity and modeling problems. Using the described algorithm, high quality images may be recovered from undersampled data which may help to reduce the scan time and the exposed invasive radiations. Using the same set of data in conventional image reconstruction algorithms (e.g. Filtered Back Projection (FBP) in CT) may cause severe streak artifacts and may take significantly more time using Graphics Processing Units (GPU) and parallel clusters with the conventional CS-based methods. This method can be used other imaging modalities using Radon transform (such as C-Arm and electron tomography, for example).

The present invention relates to a solution for solving an ill-posed inverse problem in image analysis, e.g. in an electron tomography application in order to recover a structure of a sample. The solution is provided for instance as a method comprising steps of determining reliable prior knowledge about the solution, determining initial guess for the solution and determining the corresponding forward operator, deciding upon model of stochasticity, deciding on suitable regularization method, deciding on updating scheme, and producing a sequence using the set configuration.

A method for improving image resolution of a three dimensional structure of at least one molecule conformation includes: determining a three dimensional structure of at least one conformation of a molecule in a sample from a first data set obtained from a series of 2D measurements of different geometrical projections of the molecule at a low electron beam dose in an electron microscope; producing a second data set including calculated two dimensional projections of the determined three dimensional structure of the at least one conformation of the same molecule; correlating data from a third data set obtained from at least one measurement of the same molecule using a higher electron beam dose with the second data set; and using the correlated data to improve the resolution of the three dimensional structure of the at least one conformation of the molecule by increasing the first data set with the correlated data and re-determining a three dimensional structure.

Apparatus and methods for depth-of-interaction (DOI) positron tomography detection are disclosed herein. Certain embodiments utilize dichotomous sensing to obtain DOI information.

The invention discloses a [18F]fluorine-labeled purine compound, which is 2-amino-6-[18F]fluoro-9-(4-hydroxyl-3-hydroxymethylbutyl ) Purine. The invention also discloses a preparation method of the above-mentioned [18F] fluorine-labeled purine compound and its application as a molecular probe for positron electron tomography (PET) of reporter gene HSV1-tk.

A fast projection matching method for computed tomography (CT) images is provided. The method mainly bases on an iterative algorithm. The algorithm simplifies a traditional issue of three-dimensional projection matching into a two-dimensional projection-matching problem by pre-correcting the Y-axis offset and ϕ shift of each projection intensity image using common-line concept, thereby making the complex CT alignment processing faster and more reliable. This majorly reduces the hardware requirements for CT and data processing, which facilitates the applications in other three dimensional tomographic techniques, such as X-ray micro-CT or electron tomography.

Provided is an apparatus and method for aligning fiducial markers. The apparatus may align positions of the fiducial markers on the two or more micrographs forming a two or more point sets corresponding to the two or more micrographs; create a first set of matched fiducial markers and unmatched fiducial markers; transform unmatched fiducial markers into transformed point sets and match the unmatched fiducial markers resulting in a second set of matched fiducial markers. The matching of the second set of matched fiducial markers results in improved alignment of a large number of fiducial markers. The aligned positions of fiducial markers may be constrained by an upper bound of transformation deviation of aligning positions of fiducial markers on two or more micrographs.

The invention relates to a method for measuring the mixing effect of fluids and is mainly applied to judging the mixing effect of fluids and theoretically guiding the design of experiments in experiments of chemical engineering. The method comprises the following steps: (1) utilizing a particle velometer (transparent or semi-transparent fluid mixing) and the electron tomography (nontransparent fluid mixing) to obtain a fluid mixing real-time pattern; (2) utilizing a written particular program to calculate a 0-dimension Betti number and a 1-dimension Betti number of the obtained real-time pattern; (3) judging the mixing effect through respectively calculating the evolvement of the 0-dimension Betti number and the 1-dimension Betti number of an integral region and the average value of the 0-dimension Betti number and the 1-dimension Betti number of a 4 region or a 16 region. The method is applied to the detection of the mixing effect of all fluids, is simple and convenient and has higher practical value. The invention provides a reliable and practical measuring method for judging the mixing effects and theoretically guiding the design of experiments in experiments of chemical engineering.

Provided is an apparatus and method for aligning fiducial markers. The apparatus may align positions of the fiducial markers on the two or more micrographs forming a two or more point sets corresponding to the two or more micrographs; create a first set of matched fiducial markers and unmatched fiducial markers; transform unmatched fiducial markers into transformed point sets and match the unmatched fiducial markers resulting in a second set of matched fiducial markers. The matching of the second set of matched fiducial markers results in improved alignment of a large number of fiducial markers. The aligned positions of fiducial markers may be constrained by an upper bound of transformation deviation of aligning positions of fiducial markers on two or more micrographs.