34 results about "Electron tomography" patented technology

A method for improving image resolution of a three dimensional structure of at least one molecule conformation includes: determining a three dimensional structure of at least one conformation of a molecule in a sample from a first data set obtained from a series of 2D measurements of different geometrical projections of the molecule at a low electron beam dose in an electron microscope; producing a second data set including calculated two dimensional projections of the determined three dimensional structure of the at least one conformation of the same molecule; correlating data from a third data set obtained from at least one measurement of the same molecule using a higher electron beam dose with the second data set; and using the correlated data to improve the resolution of the three dimensional structure of the at least one conformation of the molecule by increasing the first data set with the correlated data and re-determining a three dimensional structure.

A method to image objects from local three-dimensional parallel beam tomographic data (line integrals) over lines parallel an arbitrary curve of directions on a sphere. Such data are used in electron microscopy, SPECT (with weighted integrals), and synchrotron tomography. The algorithm is adaptable to a number of data sets including single-axis and double-axis tilt electron tomography and truly three-dimensional curves of directions. The method stably gives pictures of the internal structure of objects and does not add strong singularities or artefacts. It is less influenced by objects outside the region of interest than standard non-local methods. The algorithm is combined with an electron microscope and computer to provide computer readable files showing the pictures of small objects such as molecules.

The invention discloses a method for building a fractal dimension-based multi-phase mixed effect prediction model, which comprises the following steps of: (1) acquiring a multi-phase stirring mixing real-time pattern by using electron tomography or a high-rate camera; (2) computing the fractal dimension of the acquired real-time pattern by using a compiled box dimension computation program; (3) acquiring previous relative data of each period at every interval by using the method in step (2) to obtain a corresponding time sequence; (4) computing a time delay variable, an embedded dimension and a bandwidth by using the time sequence obtained in step (3) and by using a phase reconstruction method; (5) processing the time sequence in the step (3) by using a one-step-forward method and kernel regression prediction to obtain an entire time sequence; and (6) testing and verifying a prediction error by using an experimental method. The invention provides a reliable and practical prediction method for predicting the mixed effect of chemical engineering experiments and theoretically instructing stirring reactor design, stirring operation and correction experiments.

The invention relates to a method for measuring the mixing effect of fluids and is mainly applied to judging the mixing effect of fluids and theoretically guiding the design of experiments in experiments of chemical engineering. The method comprises the following steps: (1) utilizing a particle velometer (transparent or semi-transparent fluid mixing) and the electron tomography (nontransparent fluid mixing) to obtain a fluid mixing real-time pattern; (2) utilizing a written particular program to calculate a 0-dimension Betti number and a 1-dimension Betti number of the obtained real-time pattern; (3) judging the mixing effect through respectively calculating the evolvement of the 0-dimension Betti number and the 1-dimension Betti number of an integral region and the average value of the 0-dimension Betti number and the 1-dimension Betti number of a 4 region or a 16 region. The method is applied to the detection of the mixing effect of all fluids, is simple and convenient and has higherpractical value. The invention provides a reliable and practical measuring method for judging the mixing effects and theoretically guiding the design of experiments in experiments of chemical engineering.

The present invention relates to a solution for solving an ill-posed inverse problem in image analysis, e.g. in an electron tomography application in order to recover a structure of a sample. The solution is provided for instance as a method comprising steps of determining reliable prior knowledge about the solution, determining initial guess for the solution and determining the corresponding forward operator, deciding upon model of stochasticity, deciding on suitable regularization method, deciding on updating scheme, and producing a sequence using the set configuration.

The invention discloses a method for establishing a time sequence model for predicting multi-phase mixing uniformity, and is mainly applicable to predicting fluid mixing effect and theoretically guiding and correcting experiment design in a chemical engineering experiment. The method particularly comprises the following steps of: (1) acquiring a multi-phase real-time stirring and mixing pattern by using electron tomography or a high-speed camera; (2) calculating the zeroth-dimension betti number of the acquired real-time pattern by using a written program; (3) acquiring related data at the beginning every certain time by using the method of the step (2) so as to obtain a corresponding time sequence; (4) calculating time delay variable, embedded dimension and bandwidth by a phase reconstruction method by using the time sequence obtained in the step (3); (5) linearly predicting the time sequence in the step (3) by using a one-step forward method and local weighting so as to obtain the complete time sequence; and (6) verifying prediction error by using an experimental method. The model is applied to the prediction of the mixing effect of all fluid; and the method has the advantages of simplicity, convenience and extremely high practical value.

The invention relates to an improved method of electron tomography. Electron tomography is a time consuming process, as a large number of images, typically between 50-100 images, must be acquired to form one tomogram. The invention teaches a method to shorten the time needed to acquire this amount images much more quickly by tilting the sample continuously, instead of step-by-step. Hereby the time needed to reduce vibrations between steps is eliminated.

The invention relates to a method for making customized acetabular prosthesis and an auxiliary method for total hip replacement arthroplasty, which relate to the technical field of the total hip replacement arthroplasty. The method comprises the followings steps: scanning the hip joint of a patient by using an electron tomography technique before an operation, obtaining three-dimensional data of the hip joint of the patient, and introducing the obtained three-dimensional data into the three-dimensional software to reconstruct an acetabular model of the patient; processing the patient's acetabular model in the three-dimensional software to obtain the acetabular model of the patient after milling; using a reverse engineering technique to obtain a prosthetic model matching the above model, and then using a 3D printing technology to print the prosthetic model to the customized acetabular prosthesis, and using the patient acetabular model to formulate a tool milling trajectory and the milling process parameters; before the operation, introducing the tool milling trajectory and the process parameters into the robot control software, and using a robot for doctor to mill the patient's acetabulum, wherein the customized acetabular prosthesis is provided for the doctor to mount the acetabulum of the patient after milling. The method can reduce the doctor's surgical burden and improve the quality of milling.

This invention relates to a thermoplastic resin composition comprising a thermoplastic resin (A) and a reactive functional group-containing thermoplastic resin (B), which has a specific structure in the morphology of the resin composition observed by transmission electron tomography, and the relaxation time T1C of each carbon nucleus by the solid NMR measurement of the thermoplastic resin composition containing a polyamide resin is kept in a specific range. The composition is excellent in the balance between contradictory properties such as impact resistance and heat resistance, remarkably exhibits a peculiar viscoelastic behavior not observed in the conventional polymeric materials, and is remarkably excellent in impact energy absorbing performance and vibration energy absorbing performance at the time of high-speed deformation.

A fast projection matching method for computed tomography (CT) images is provided. The method mainly bases on an iterative algorithm. The algorithm simplifies a traditional issue of three-dimensional projection matching into a two-dimensional projection-matching problem by pre-correcting the Y-axis offset and ϕ shift of each projection intensity image using common-line concept, thereby making the complex CT alignment processing faster and more reliable. This majorly reduces the hardware requirements for CT and data processing, which facilitates the applications in other three dimensional tomographic techniques, such as X-ray micro-CT or electron tomography.

Disclosed is a method for providing nanoporous palladium and platinum powders. These materials were synthesized on milligram to gram scales by chemical reduction of tetrahalo-complexes with ascorbate in a concentrated aqueous surfactant at temperatures between −20° C. and 30° C. The prepared particles have diameters of approximately 50 nm, wherein each particle is perforated by pores having diameters of approximately 3 nm, as determined by electron tomography. These materials are of potential value for hydrogen and electrical charge storage applications.

Provide an electrode catalyst with excellent catalytic activity that can contribute to cost reduction of PEFC. The electrode catalyst includes a hollow carbon carrier with mesopores with a pore size of 2 to 50 nm and a catalyst particle supported on the carrier. The catalyst particle is supported on both inside and outside the mesopores of the carrier, and have a core portion formed on the carrier and a shell portion covering at least a part of the surface of the core portion. Pd is included in the core portion, and Pt is included in the shell portion, and when the analysis of the particle size distribution of the catalyst particles using the three dimensional reconstructed image obtained by electron beam tomography (electron tomography) measurement using an STEM is performed, the ratio of the catalyst particles supported inside the mesopore is 50% or more.

The invention discloses a frozen electron cross-sectional image-oriented mismatching removal method, which comprises the following steps of: S1, screening stable matching from a group of frozen electron cross-sectional image pairs, and extracting motion information between feature points as a training sample; s2, inputting the training sample obtained in the S1 into a pre-constructed nonlinear regression model, and fitting an identification function for calculating all matching correctness probabilities of the frozen electron cross-sectional image pair through training; s3, an identification function is obtained based on training fitting in the S2, and the frozen electron cross-sectional image pair is calculated to obtain an initial matching group; s4, repeating S1, S2 and S3 until an initial matching group of all the frozen electron cross-sectional image pairs is obtained; and S5, on the basis of all the initial matching groups, finishing final mismatching removal work through an RANSAC (Random Sample Consensus) algorithm. According to the method, the wrong matching is removed by using the motion consistency between the electron tomography projection image sequences, so that the correct matching between the images is effectively kept, and meanwhile, the accuracy of the alignment result is improved.

The invention provides a diameter estimation method for colloidal gold in an electron tomography image. The diameter estimation method comprises that 1) a series of estimation diameters are obtained within the value range close to the diameter of original colloidal gold; 2) the cross correlation coefficient between a manual template and an average template is calculated under each estimation diameter and serves as a template matching cross correlation coefficient, the manual template is a colloidal gold template directly generated according to the estimation diameter, and the average template is a colloidal gold template obtained by extracting colloidal gold according to the estimation diameter and averaging images in the extracted colloidal gold area; and 3) the accurate diameter of the colloidal god is determined according to template matching cross correlation coefficients corresponding to the different estimation diameters. The invention also provides a corresponding automatic identification method for colloidal gold. Methods of the invention are less dependent on parameters as the diameter and amount of the colloidal gold, and the identification rate is higher.

The invention discloses a feature extraction method for a frozen electron cross-sectional image. The method comprises the following steps: S1, acquiring a projected image of a frozen electron cross-sectional image and a corresponding image sequence; s2, presetting an angle sequence of affine transformation simulation; s3, according to a set angle sequence, affine transformation simulation is carried out on the projection image of each frozen electron tomography, and a corresponding simulation image set is obtained after screening; and S4, according to the analog image set obtained in the S3 and the corresponding angle sequence, extracting and obtaining matched feature points. According to the method, through the simulated image set and the corresponding angle sequence, the interference on the spatial position of the sample during manual tilting is solved, and the extraction quality of the feature points is improved, so that a high-quality frozen electron three-dimensional reconstruction model is obtained.