The invention discloses an anti-pigeon pox traditional Chinese medicine composition, which comprises the following components in parts by weight: 25-45 parts of kudzu root, 25-45 parts of forsythia, 20-35 parts of Cimicifuga, 20-35 parts of Smilax cocos, Qu Mai 20-35 parts, 15-30 parts of honeysuckle, 15-30 parts of licorice. The invention also discloses a preparation method of the oral liquid of the anti-pox traditional Chinese medicine composition. In the present invention, the use of traditional Chinese medicines instead of western medicines for pigeon pox virus infection can reduce or eliminate drug residues in poultry meat and eggs, thereby facilitating the pollution-free production of livestock products; and can be widely used in the treatment of various poultry including pigeons Pox virus infection: Pigeons suffering from pox virus infection can obtain significant curative effect by using this product, and the cure rate is over 95%. Especially for the pox scabs, they will fall off and heal within one week after medication, and will not recur.