3 results about "Poxvirus Infections" patented technology

This invention discloses a monkeypox virus nanoparticle vaccine based on an HBc-VLP vector, its preparation method, and its application, belonging to the field of biomedical technology. The vaccine uses HBc-VLP as a backbone with SpyCatcher sites on its surface. Through a SpyTag / SpyCatcher coupling system, antigenic polypeptides derived from the monkeypox virus M1R protein (containing overlapping epitopes for B cells and T cells) are loaded onto the VLP surface in a high-density, directed, and stable manner. This design mimics the structure of natural viral particles and can efficiently activate humoral and cellular immunity. The epitopes, screened by immunoinformatics, exhibit high antigenicity, broad-spectrum HLA affinity, and are non-toxic and non-sensitizing. This invention also provides an immunomodulatory composition containing this vaccine and its application in the preparation of drugs for the prevention or treatment of monkeypox virus infection. The vaccine preparation process is simple, has strong antigen compatibility, and has good industrialization prospects.

The current disclosure includes a modular vaccine platform. Also included are monkeypox vaccines that protect against pathogenic monkeypox (Mpox) species, as well as their variants. The vaccines typically include a modified mRNA encoding at least one immunogen, such as a viral envelope protein, cell surface binding protein, or a biologically effective / significant fragment thereof. The mRNA can be encapsulated into lipid nanoparticles or other carriers and formulated as pharmaceutical compositions that can be used to generate an immune response to pathogens, including monkeypox virus, in a subject.

The application relates to the technical field of biological medicine, and particularly discloses an anti-positive poxvirus monoclonal antibody and application thereof. The anti-positive poxvirus monoclonal antibody provided by the application is 4H4, 12C3 or 11C9. The anti-positive poxvirus monoclonal antibody provided by the application can specifically recognize and target monkeypox, vaccinia and other positive poxviruses, and shows high virus neutralization capacity, and can be used for preparing a medicine for preventing and / or treating positive poxvirus infection and / or a disease related to positive poxvirus infection, or preparing a detection product for detecting positive poxviruses and diagnosing a disease related to positive poxvirus infection.