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The invention relates to a biological preventing and controlling strain of continuous cropping cucumber and watermelon blight and microbe organic fertilizer thereof, belonging to agriculture intensification production technologies. Trichoderma harzianum SQR-T037 having obvious biological preventing and controlling effect on cucumber and watermelon blight is separated, and the microbe organic fertilizer is prepared from the biological preventing and controlling strain and organic compost; the fertilizer contains more than 1*108 bacterial colony forming units per gram of the strain, the full nitrogen content is 3-5 percent (more than 90 percent is organic nitrogen), the total NPK nutrient content is 6-10 percent, and the organic matter content is 30-35 percent. An experiment indicates that the microbe organic fertilizer leads the biological preventing and controlling strain to be rapidly bred after being applied to the soil and forms a preponderant population in the soil, and the biological preventing and controlling rate of the blight in the soil having serious cucumber and watermelon blight reaches more than 85 percent. By applying the microbe organic fertilizer to the soil without forming continuous cropping obstruction for a long time, the preventing and controlling rate on the cucumber and watermelon blight reaches more than 80 percent.