The invention discloses a full-automatic non-woven fabric shoe cover overlock machine. A roll non-woven fabric shoe cover raw material is subjected to processes of automatic feeding, folding, tailoring, sewing, discharging and the like by the machine, and automatic production of a shoe cover is completed; the sewing process comprises steps as follows: sewing of a shoe cover opening, folding, sewing of a shoe sole opening, tailoring and sewing of a circular arc edge; straight line and circular arc combined guide tracks are designed, the production time of a single shoe cover is shorter than or equal to 3 seconds; the overlock machine commonly used in the market is used for sewing an elastic band onto the shoe cover; a folding mechanism is always in a horizontal state in the folding process and matched with a conveying speed; the semi-circular arc edge is sewn through self-rotation of a clamp, and the circular arc is at the front end of the made shoe cover and is attractive and fit for a foot; a special tailoring mechanism is designed, and fusing is not required; non-woven fabric coated with anti-slip coating can be used, an anti-slip strip is not required to be pressed, and a product is anti-static, breathable and wear-resisting; and the machine occupies little space, the stations are smoothly connected, a small long strip is not required to be folded for wrapping the elastic band, the noise is low, and the folding mechanism is simple, flexible and stable in folding and cannot tear the raw material.