A thin-film transistor substrate includes a base substrate, a gate line, a data line, a thin-film transistor, an organic insulating pattern and a common electrode. The base substrate includes a plurality of pixel areas. The gate line is disposed on the base substrate, and the gate line is extended in a first direction. The data line is disposed on the gate line, and the data line is extended in a second direction crossing the first direction. The thin-film transistor is connected to the gate line and the data line. The organic insulating pattern covers the data line and the thin-film transistor, and the organic insulating pattern includes an opening overlapping with the pixel areas. The common electrode is disposed on the base substrate. Thus, an organic insulating layer in a pixel area may be partially removed, so that a yellowish screen may be prevented, thereto improve a display quality. In addition, an organic insulating pattern may be formed on a data pattern, a coupling capacitance between the data pattern and a common electrode may be prevented or decreased, thereto prevent a data signal delay.