46results about How to "Easy for industrial automation production" patented technology

The invention relates to new type GLP-1 analogues and a microwave promotive solid phase synthesis process of the same. GLP-1 analogues with longer pharmacological action time can be obtained by modifying 8, 9, 16, 22, 27 or 37 sites of natural GLP-1, the chemical synthesis is highly effectively and rapidly realized by microwave promotive solid phase synthesis process, the crude product is purified by highly effective liquid phase, and GLP-1 analogues is obtained after lyophilized.

The invention relates to a method for preparing hidden-type emitter silicon solar cells, which adopts a quadratic diffusion process. The method comprises the following steps: 1. laser boring; 2. cleaning, radiation damage removing and suede preparation; 3. diffusion; 4. hiding launching area; 5. emitter area corrosion and periphery joint removing; 6. hiding removing; 7. oxidizing and surface passivation; 8. screen printing electrode; and 9. sintering. The method can prepare the hidden-type emitter silicon solar cells.

The invention relates to a novel oxyntomodulin (OXM) analogue and a synthesis method thereof. A terminal C of natural OXM is subjected to Ex-4, GLP-1 and Lixisenatide partial terminal C peptide sequence substitution to obtain the OXM analogue with optimal pharmacological activity, synthesis of a peptide chain is rapidly implemented by an orthogonal protection strategy solid phase synthesis method, a coarse product is purified and freeze-dried to obtain the OXM analogue.

The invention discloses a series of GLP-1 agonist polypeptide compounds, and belongs to the technical field of polypeptide medicinal chemistry. Aiming at defects of in-vivo stability, hypoglycemic andweight-reducing effects, side effects and the like of existing compounds, the invention provides a series of GLP-1 agonist polypeptide compounds with better hypoglycemic activity and weight-reducingeffects by utilizing a dual action mechanism. The GLP-1 agonist polypeptide compound has an amino acid sequence: H Xaa1EGTFTSDVSSYLE Xaa2QAA Xaa3EFIAWLVRGRG, and a C-terminal amino acid of the polypeptide compound as the C-terminal carboxyl group or carboxyl group is amidated. The invention also discloses a preparation method, a pharmaceutically acceptable salt, a pharmaceutical composition and amedicament of the polypeptide compound. The polypeptide compound has effects of reducing blood sugar and weight, and can be used as an effective raw material for preparing a medicament for treating orpreventing diabetes or as a weight-losing medicament.

The invention relates to a preparation technology of a ceramic dielectric resonator for TM communication applied to microwave components such as dielectric resonators, filters and oscillators in satellite communication and mobile communication systems and a GPS global positioning system. Microwave dielectric ceramic is prepared from the following raw materials: barium oxide (BaO), titanium dioxide (TiO2), zinc oxide (ZnO) and niobium pentoxide (Nb2O5) and a trace amount of doped additives copper oxide (CuO) and manganese oxide (MnO); and the components are subjected to solid-phase reaction procedures of burdening, mixing, ball-milling, pelleting, molding, bowl filling, rubber discharging and sintering to fire the microwave dielectric ceramic. The technology has the advantages of being low in sintering temperature, energy-saving, environment-friendly, high in dielectric constant, high in quality factor and stable in resonance frequency temperature characteristics.

The invention relates to long-acting glucagon-like peptide 1 (GLP-1) analogues and a synthesis method thereof. GLP-1 analogues with longer pharmacological action time are obtained through modifying the 17th residue of natural GLP-1, the synthesis of target polypeptides is quickly realized through a microwave-promoted solid-phase synthesis method, and crude products are purified and freeze-dried to obtain the GLP-1 analogues.

The invention relates to the technical field of bobbin winders, in particular to a method for preparing mixed-color single yarns and a device for implementing the method, and aims to solve the problems that the conventional mixed-color single yarn product has a monotonous color, fibers of single-color yarns are not blended, and plied yarns are simply twisted. The method is characterized by comprising the following steps of: selecting the single-color yarns according to the color design requirement, wetting the single-color yarns in a water tank, untwisting each strand of single-color yarns, performing pressing multi-strand mixing drafting, and twisting to form a strand of mixed-color single yarns. Industrial automatic production is easy to implement, the mixed-color single yarn product has abundant colors, a braided fabric is high in third dimension and personality and has a unique style, and the method is suitable for preparing the mixed-color single yarns made of various materials such as flax, cotton, fibers and silk.

The invention provides a flexible plastic magnetic diaphragm material with regenerated plastics, which is prepared from the following raw material components in percentage by weight: 72 to 85 percent of magnetic powder, 0 to 28 percent of regenerated plastics, 0 to 28 percent of thermoplastic plastics and 0 to 3 percent of assistant. The method for preparing the flexible plastic magnetic diaphragm material comprises: mixing the magnetic powder, the regenerated plastic, the thermoplastic plastics and the assistant in a ratio; extruding the mixture in an extruder to cast a film; and cooling and setting film by two rolls or a plurality of rolls to obtain the product. In the invention, the repeated use of the regenerated plastics in the plastic magnetic material is realized, oil resource is saved and carbon emission is reduced; meanwhile, the flexible plastic magnetic diaphragm material which is thinner and wider than rubber magnetic material can be prepared.

The invention provides a preparation method for ceramic adopting a high-temperature biscuit glaze pouring mode. The preparation method comprises the following steps of: firstly, biscuiting ceramic paste to obtain biscuit with water absorption smaller than 5%; and then, pouring glaze on the surface of the ceramic paste by adopting a bell glaze pouring mode, and carrying out glaze firing, wherein the glaze firing temperature is lower than the biscuit firing temperature by 50-250 DEG C. According to the technical scheme adopted by the invention, the prepared ceramic product is good in regularity, and defects such as glaze pin holes, glaze bubbles are greatly reduced, the glaze is uniform, the quality is excellent, and the product quality and the stability are improved.

The invention relates to a class of long-acting glucagon-like peptide-1 (GLP-1) analogs and a synthesis method thereof. GLP-1 analogues with longer pharmacological action time were obtained by modifying GLP-1. The synthesis of the target polypeptide was quickly realized through the solid-phase synthesis method of orthogonal protection strategy. The crude product was purified and lyophilized to obtain GLP-1 analogues. thing.

The invention relates to the technical field of bobbin winders, in particular to a method for preparing mixed-color single yarns and a device for implementing the method, and aims to solve the problems that the conventional mixed-color single yarn product has a monotonous color, fibers of single-color yarns are not blended, and plied yarns are simply twisted. The method is characterized by comprising the following steps of: selecting the single-color yarns according to the color design requirement, wetting the single-color yarns in a water tank, untwisting each strand of single-color yarns, performing pressing multi-strand mixing drafting, and twisting to form a strand of mixed-color single yarns. Industrial automatic production is easy to implement, the mixed-color single yarn product has abundant colors, a braided fabric is high in third dimension and personality and has a unique style, and the method is suitable for preparing the mixed-color single yarns made of various materials such as flax, cotton, fibers and silk.

The invention relates to a long-effecting exenatide (Exendin-4) analogue and a synthetic method thereof. The Exendin-4 is modified to obtain the Exendin-4 analogue with longer pharmacologic action time, the synthesis of target polypeptide is quickly realized through an orthogonally protection strategy solid-phase synthesis method, and a crude product is purified and freeze-dried to obtain the Exendin-4 analogue.

The invention is a long-acting exenatide derivative, which belongs to the technical field of polypeptide compounds. The exenatide derivative is structurally optimized for the exenatide sequence, so that it has hypoglycemic and weight-reducing effects at the same time, and double the amount of exenatide is conjugated with a single amount of fatty acid chains. The fatty acid chain plays a binding role with serum albumin to obtain exenatide derivatives with longer pharmacological action time. The invention also discloses a preparation method of exenatide derivatives, a pharmaceutically acceptable salt of exenatide derivatives, a pharmaceutical composition of exenatide derivatives, a pharmaceutical composition and a use thereof. Application of the derivative in the preparation of medicines for treating and / or preventing diabetes, obesity, hyperlipidemia and non-alcoholic fatty liver. The long-acting exenatide derivatives can reduce the weight on the basis of retaining the hypoglycemic activity, and the biological half-life is significantly longer than that of the exenatide prototype, and some of them have reached more than 36 hours, which greatly prolongs the hypoglycemic effect. Time of bariatric action.

The invention relates to the design and synthesis method of a novel long-acting hypoglycemic peptide. Exendin-4 derivatives with longer pharmacological action time were obtained by modifying Exendin-4. The synthesis of the target polypeptide was quickly realized through the solid phase synthesis method of orthogonal protection strategy. The crude product was purified and lyophilized to obtain long-acting chemical derivatives. Glycopeptides.