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46results about How to "Easy for industrial automation production" patented technology

Micro-wave promoted solid-phase synthesis of glucagons-like peptide-1(GLP-1) analogue and uses thereof

The invention relates to new type GLP-1 analogues and a microwave promotive solid phase synthesis process of the same. GLP-1 analogues with longer pharmacological action time can be obtained by modifying 8, 9, 16, 22, 27 or 37 sites of natural GLP-1, the chemical synthesis is highly effectively and rapidly realized by microwave promotive solid phase synthesis process, the crude product is purified by highly effective liquid phase, and GLP-1 analogues is obtained after lyophilized.
Owner:CHINA PHARM UNIV

Glucagons like peptide-1 (GLP-1) analog and application thereof

The invention relates to a novel long-acting glucagons like peptide-1 (GLP-1) analog and a synthesis method thereof. The synthesis method comprises the following steps: modifying the 8th, 23rd or 37th site of the natural GLP-1 to obtain the GLP-1 analog having longer pharmacological action time; quickly synthesizing a peptide chain by adopting a microwave-promoted solid-phase synthesis method; reacting cysteine residues with a 4-hydroxyl coumarin analog to obtain a target polypeptide; purifying the crude product; and carrying out freeze-drying to obtain the GLP-1 analog.
Owner:CHINA PHARM UNIV

Long-acting glucagon-like peptide 1 (GLP-1) analogues and application thereof

The invention relates to long-acting glucagon-like peptide 1 (GLP-1) analogues and a synthesis method thereof. GLP-1 analogues with longer pharmacological action time are obtained through adding a modified 37th amino acid to natural GLP-1, the synthesis of target polypeptides is quickly realized through a microwave-promoted solid-phase synthesis method, and crude products are purified and freeze-dried to obtain the GLP-1 analogues.
Owner:CHINA PHARM UNIV

GIP and GLP-1 double-agonistic polypeptide compound and pharmaceutically acceptable salt and application thereof

The invention discloses a GIP and GLP-1 double-agonistic polypeptide compound, and belongs to the technical field of polypeptide medicinal chemistry. The GIP and GLP-1 double-agonistic polypeptide compound has an amino acid sequence as follows: YXaa1EGTFTSDYSIXaa2LDKIAQXaa3AFVQWLIAGGPSSGAPPPS, and C-terminal amino acid of the polypeptide compound is amidated as a C-terminal primary amide. The invention relates to a preparation method, a pharmaceutically acceptable salt, a pharmaceutical composition and a medicament of the polypeptide compound. The polypeptide compound disclosed by the invention has effects of reducing blood glucose and losing weight, and can be used as an effective raw material for preparing a medicament for treating or preventing diabetes or a weight-losing medicament.
Owner:杭州禾泰健宇生物科技有限公司

Long-effecting exenatide (Exendin-4) analogue and application thereof

The invention relates to a long-effecting exenatide (Exendin-4) analogue and a synthetic method thereof. The Exendin-4 is modified to obtain the Exendin-4 analogue with longer pharmacologic action time, the synthesis of target polypeptide is quickly realized through an orthogonally protection strategy solid-phase synthesis method, and a crude product is purified and freeze-dried to obtain the Exendin-4 analogue.
Owner:CHINA PHARM UNIV

Method for preparing hidden-type emitter silicon solar cells

The invention relates to a method for preparing hidden-type emitter silicon solar cells, which adopts a quadratic diffusion process. The method comprises the following steps: 1. laser boring; 2. cleaning, radiation damage removing and suede preparation; 3. diffusion; 4. hiding launching area; 5. emitter area corrosion and periphery joint removing; 6. hiding removing; 7. oxidizing and surface passivation; 8. screen printing electrode; and 9. sintering. The method can prepare the hidden-type emitter silicon solar cells.
Owner:YUNNAN NORMAL UNIV

Glucagon-like peptide 1 (GLP-1) analogues with long-acting effect and application thereof

The invention relates to glucagon-like peptide 1 (GLP-1) analogues with a long-acting effect and a synthesis method thereof. GLP-1 analogues with longer pharmacological action time are obtained through replacing / modifying 17th, 26th, 34th and 37th amino acids of natural GLP-1, the synthesis of target polypeptides is quickly realized through a microwave-promoted solid-phase synthesis method, and crude products are purified and freeze-dried to obtain the GLP-1 analogues.
Owner:CHINA PHARM UNIV

Class of long-acting glucagon-like peptide-1 (GLP-1) analog and application thereof

The invention relates to a class of long-acting glucagon-like peptide-1 (GLP-1) analog and a synthesis method thereof. The GLP-1 analogue with longer pharmacological action time is obtained by modifying GLP-1. The synthesis of target polypeptide is quickly achieved by a orthogonal protection strategy solid phase synthesis method. The crude product is purified and lyophilized to obtain the GLP-1 analog.
Owner:CHINA PHARM UNIV

Oxyntomodulin (OXM) analogue and application thereof

The invention relates to a novel oxyntomodulin (OXM) analogue and a synthesis method thereof. A terminal C of natural OXM is subjected to Ex-4, GLP-1 and Lixisenatide partial terminal C peptide sequence substitution to obtain the OXM analogue with optimal pharmacological activity, synthesis of a peptide chain is rapidly implemented by an orthogonal protection strategy solid phase synthesis method, a coarse product is purified and freeze-dried to obtain the OXM analogue.
Owner:CHINA PHARM UNIV

Novel long-acting glucagon-like peptide 1 (GLP-1) analogues and application thereof

The invention relates to novel long-acting glucagon-like peptide 1 (GLP-1) analogues and a synthesis method thereof. GLP-1 analogues with longer pharmacological action time are obtained through replacing / modifying 17th, 26th, 34th and 37th amino acids of natural GLP-1, the synthesis of target polypeptides is quickly realized through a microwave-promoted solid-phase synthesis method, and crude products are purified and freeze-dried to the GLP-1 analogues.
Owner:CHINA PHARM UNIV

Design and application of novel long acting hypoglycemic peptide

The invention relates to design and synthetic method of novel long acting hypoglycemic peptide. An Exending-4 derivative with longer pharmacological action time is obtained through the transformation on Exending-4, synthesis of target polypeptide is rapidly realized through an orthogonally protect strategy solid-phase synthesis method, and a crude product is subjected to purification and freeze-drying, so that the long acting hypoglycemic peptide is obtained.
Owner:CHINA PHARM UNIV

GLP-1 agonist polypeptide compound, salt thereof, synthesis method and application thereof

ActiveCN111253475ALow immunogenicity propertiesIncrease activity is goodPeptide-nucleic acidsPeptide/protein ingredientsCarboxyl radicalSide effect
The invention discloses a series of GLP-1 agonist polypeptide compounds, and belongs to the technical field of polypeptide medicinal chemistry. Aiming at defects of in-vivo stability, hypoglycemic andweight-reducing effects, side effects and the like of existing compounds, the invention provides a series of GLP-1 agonist polypeptide compounds with better hypoglycemic activity and weight-reducingeffects by utilizing a dual action mechanism. The GLP-1 agonist polypeptide compound has an amino acid sequence: H Xaa1EGTFTSDVSSYLE Xaa2QAA Xaa3EFIAWLVRGRG, and a C-terminal amino acid of the polypeptide compound as the C-terminal carboxyl group or carboxyl group is amidated. The invention also discloses a preparation method, a pharmaceutically acceptable salt, a pharmaceutical composition and amedicament of the polypeptide compound. The polypeptide compound has effects of reducing blood sugar and weight, and can be used as an effective raw material for preparing a medicament for treating orpreventing diabetes or as a weight-losing medicament.
Owner:HANGZHOU ALLSINO CHEM

Girald daphne bark adhesive paste and preparation method thereof

The invention relates to a girald daphne bark adhesive paste. The adhesive paste is prepared from the following raw materials in parts by weight: 5-10 parts of a traditional Chinese medicine extract, 1-5 parts of an adhesive, 0.1-0.5 part of a filling agent, 0.1-0.5 part of a transdermal absorption enhancer, 5-15 parts of a moisturizing agent, 0.1-0.5 part of a crosslinking agent, 0.1-0.5 part of a crosslinking regulator, 0.1-0.5 part of a thickening agent and 15-20 parts of distilled water. Meanwhile, the invention also discloses a preparation method of the girald daphne bark adhesive paste. The girald daphne bark adhesive paste disclosed by the invention has the effects of resisting inflammation and easing pain, and can be applied to the treatment on rheumatism, rheumatoid diseases and swellings and pains caused by various reasons.
Owner:甘肃省医学科学研究院

Preparation technology of ceramic dielectric resonator for TM communication

The invention relates to a preparation technology of a ceramic dielectric resonator for TM communication applied to microwave components such as dielectric resonators, filters and oscillators in satellite communication and mobile communication systems and a GPS global positioning system. Microwave dielectric ceramic is prepared from the following raw materials: barium oxide (BaO), titanium dioxide (TiO2), zinc oxide (ZnO) and niobium pentoxide (Nb2O5) and a trace amount of doped additives copper oxide (CuO) and manganese oxide (MnO); and the components are subjected to solid-phase reaction procedures of burdening, mixing, ball-milling, pelleting, molding, bowl filling, rubber discharging and sintering to fire the microwave dielectric ceramic. The technology has the advantages of being low in sintering temperature, energy-saving, environment-friendly, high in dielectric constant, high in quality factor and stable in resonance frequency temperature characteristics.
Owner:CHENZHOU GONGTIAN ELECTRONICS CERAMICS TECH

Novel peptide conjugate of African clawed frog GLP-1 (glucagon like peptide-1), as well as application thereof

The invention relates to a novel peptide conjugate of African clawed frog GLP-1 (glucagon like peptide-1), as well as a synthesis method and application thereof. A spiral promoting sequence is introduced to a terminal C of the African clawed frog GLP-1, and meanwhile, PEG (polyethylene glycol)-based modification is performed to obtain an analogue, with reserved hypoglycemic activity and longer pharmacological action time, of the African clawed frog GLP-1. The analogue of the African clawed frog GLP-1 has the advantages of high synthesis yield and low cost, the half-life of the analogue is remarkably prolonged, and the bioactivity is remarkably improved.
Owner:XUZHOU NORMAL UNIVERSITY

Long-acting African clawed frog glucagon-like peptide-1 (GLP-1) analogue and application thereof

The invention relates to a long-acting African clawed frog glucagon-like peptide-1 (GLP-1) analogue as well as a synthesis method and application thereof. An African clawed frog glucagon-like peptide-1 is subjected to PEG (Polyethylene Glycol) modification to obtain the African clawed frog GLP-1 analogue which can keep blood glucose lowering activity and has longer pharmacological action time. The African clawed frog GLP-1 analogue provided by the invention is high in synthesis yield and low in cost; and the half-life period of the analogue is remarkably prolonged and the biological activity is remarkably improved.
Owner:XUZHOU NORMAL UNIVERSITY

Glucagon-like peptide-1(GLP-1) analogue with ether bond and application thereof

The invention relates to a long-acting glucagon-like peptide-1(GLP-1) analogue and a synthetic method thereof. The GLP-1 analogue with longer pharmacological action time is obtained through modifying GLP-1; the synthesis of target polypeptides is rapidly realized by an orthogonal protection strategy solid-phase synthesis method; a crude product is purified and freeze-dried to obtain the GLP-1 analogue.
Owner:CHINA PHARM UNIV

Long-acting glucagon-like peptide 1 (GLP-1) analogues and application thereof

The invention relates to long-acting glucagon-like peptide 1 (GLP-1) analogues and a synthesis method thereof. GLP-1 analogues with longer pharmacological action time are obtained through modifying the 17th residue of natural GLP-1, the synthesis of target polypeptides is quickly realized through a microwave-promoted solid-phase synthesis method, and crude products are purified and freeze-dried to obtain the GLP-1 analogues.
Owner:CHINA PHARM UNIV

Method for solid phase synthesis of bitter gourd MC-JJ6 peptide analogs under microwave irradiation and application of bitter gourd MC-JJ6 peptide analogs

The invention relates to new bitter gourd MC-JJ6 peptide analogs capable of efficiently regulating blood sugar level, and a method for solid phase synthesis of bitter gourd MC-JJ6 peptide analogs under microwave irradiation. The method comprises the following steps: obtaining the MC-JJ6 peptide analogs having longer pharmacological effect time by modifying 2, 4, 5, 8 or 9 site of natural bitter gourd analogs; efficiently and quickly realizing the chemical synthesis of the MC-JJ6 peptide analogs by adopting a solid phase synthesis method under microwave irradiation; purifying the crude products by using preparation grade highly effective liquid phase; and freeze-drying the purified products to obtain the MC-JJ6 peptide analogs.
Owner:CHINA PHARM UNIV

Connection method between cam and axle tube of jacket assembling cam shaft

The invention relates to a method for connecting a cam and a shaft tube of a set assembled camshaft, which can effectively resolve the problems of infirm connection of the cam, poor utilization effect and short service life. The resolution technical proposal is as follows: firstly processing straight knurlings or cogs at the inner hole of the cam, processing threads or circular grooves at the position of the external surface of the shaft tube, the position where the cam is sheath, and the threads or the circular grooves on the external surface of the shaft tube are pressed on the straight knurlings or cogs at the inner hole of the cam for embedding in a mutually crossed way so as to construct a firm integral structure of the cam and the shaft tube. For the invention, the method is simple, the connection is firm, the cost is low, the productivity is high, the service life of the product is long, and industrial automatic production can be realized easily.
Owner:河南中轴集团有限公司

Method for preparing mixed-color single yarns and device for implementing method

The invention relates to the technical field of bobbin winders, in particular to a method for preparing mixed-color single yarns and a device for implementing the method, and aims to solve the problems that the conventional mixed-color single yarn product has a monotonous color, fibers of single-color yarns are not blended, and plied yarns are simply twisted. The method is characterized by comprising the following steps of: selecting the single-color yarns according to the color design requirement, wetting the single-color yarns in a water tank, untwisting each strand of single-color yarns, performing pressing multi-strand mixing drafting, and twisting to form a strand of mixed-color single yarns. Industrial automatic production is easy to implement, the mixed-color single yarn product has abundant colors, a braided fabric is high in third dimension and personality and has a unique style, and the method is suitable for preparing the mixed-color single yarns made of various materials such as flax, cotton, fibers and silk.
Owner:HANGZHOUSNGLU SILK

Preparation method for ceramic adopting high-temperature biscuit glaze pouring mode

The invention provides a preparation method for ceramic adopting a high-temperature biscuit glaze pouring mode. The preparation method comprises the following steps of: firstly, biscuiting ceramic paste to obtain biscuit with water absorption smaller than 5%; and then, pouring glaze on the surface of the ceramic paste by adopting a bell glaze pouring mode, and carrying out glaze firing, wherein the glaze firing temperature is lower than the biscuit firing temperature by 50-250 DEG C. According to the technical scheme adopted by the invention, the prepared ceramic product is good in regularity, and defects such as glaze pin holes, glaze bubbles are greatly reduced, the glaze is uniform, the quality is excellent, and the product quality and the stability are improved.
Owner:SHENZHEN YONGFENGYUAN PORCELAIN

Method for solid phase synthesis of bitter gourd MC-JJ2622 peptide analogs under microwave irradiation and application of bitter gourd MC-JJ222 peptide analogs

The invention relates to new bitter gourd MC-JJ6222 peptide analogs capable of efficiently regulating blood sugar level, and a method for solid phase synthesis of bitter gourd MC-JJ6222 peptide analogs under microwave irradiation. The method comprises the following steps: obtaining the MC-JJ6222 peptide analogs having longer pharmacological effect time by modifying 2, 4, 5, 8 or 9 site of natural bitter gourd analogs; efficiently and quickly realizing the chemical synthesis of the MC-JJ6222 peptide analogs by adopting a solid phase synthesis method under microwave irradiation; purifying the crude products by using preparation grade highly effective liquid phase; and freeze-drying the purified products to obtain the MC-JJ6222 peptide analogs.
Owner:CHINA PHARM UNIV

A class of long-acting exenatide (exendin-4) analogues and their applications

The invention relates to a long-effecting exenatide (Exendin-4) analogue and a synthetic method thereof. The Exendin-4 is modified to obtain the Exendin-4 analogue with longer pharmacologic action time, the synthesis of target polypeptide is quickly realized through an orthogonally protection strategy solid-phase synthesis method, and a crude product is purified and freeze-dried to obtain the Exendin-4 analogue.
Owner:CHINA PHARM UNIV

Long-acting Exenatide Derivatives and Salts, Preparation Methods and Applications

The invention is a long-acting exenatide derivative, which belongs to the technical field of polypeptide compounds. The exenatide derivative is structurally optimized for the exenatide sequence, so that it has hypoglycemic and weight-reducing effects at the same time, and double the amount of exenatide is conjugated with a single amount of fatty acid chains. The fatty acid chain plays a binding role with serum albumin to obtain exenatide derivatives with longer pharmacological action time. The invention also discloses a preparation method of exenatide derivatives, a pharmaceutically acceptable salt of exenatide derivatives, a pharmaceutical composition of exenatide derivatives, a pharmaceutical composition and a use thereof. Application of the derivative in the preparation of medicines for treating and / or preventing diabetes, obesity, hyperlipidemia and non-alcoholic fatty liver. The long-acting exenatide derivatives can reduce the weight on the basis of retaining the hypoglycemic activity, and the biological half-life is significantly longer than that of the exenatide prototype, and some of them have reached more than 36 hours, which greatly prolongs the hypoglycemic effect. Time of bariatric action.
Owner:SINOPEP ALLSINO BIOPHARMACEUTICAL CO LTD +1
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