The invention provides a cotton packing machine with a box removing pressurizing function and a box removing method. The machine comprises a main pressure oil cylinder assembly, box removing cylinders, a main pressure cross beam, box removing discs, cotton box lifting lugs, a cotton box, a rotating disc and a lower cross beam assembly, wherein two driving devices are arranged in the lower cross beam assembly, and the left and right ends of the rotating disc are provided with two locking holes by taking a rotating shaft as an axis. In the box removing process, the cotton box is moved upwards through oil cylinders, and then cotton and the cotton box are preliminarily separated; and after the oil cylinders finish the stroke, the box removing cylinders continue to move upwards, the cotton andthe cotton box are thoroughly separated, and the box removing process is completed. According to the machine and the method, box removing of the cotton packing machine is simple, the stress of the cotton box lifting lugs is reduced, and the problem that the cotton box lifting lugs are damaged due to overlarge impact force is avoided.