33results about How to "Has an immunosuppressive effect" patented technology

A medical application of periplocoside A and E in preparing the immunodepress ant with high effect and low poison is disclosed.

An alkannin derivative as immuno-suppressive agent and its metallic complex compound with a chemical constitution formulas III and IV disclosed in the specification, wherein in formula III, R is C1-6 saturated, unsaturated and aromatic acyl, in formula IV, R is hydrogen, C1-6 saturated, unsaturated and aromatic acyl, M is metallic Cu, Ca, Zn. The present invention realizes immunological suppression effect, thus can be used for treating diseases relating to human body autoimmune including chronic infectious arthritis, scleredema, lupus erythematosus, HIV infection and malignant tumor.

The invention relates to medicine for restoring wound, in particular to a preparation method of a novel medical cell repairing agent. The preparation method has the concrete preparation steps of separation purification and culture of human amniotic mesenchymal stem cells, preparation of a sodium alginate complexing agent and preparation of a cell restoring agent. The invention builds the preparation method of human amniotic mesenchymal stem cells and a corresponding stem cell bank, and makes the preparation for large-scale production and preparation of the human amniotic mesenchymal stem cellrepairing agent and the application of the repairing agent.

The invention belongs to the field of Chinese medicament, and provides a Chinese medicinal composition for treating prostatitis or prostate hyperplasia and a preparation method for the Chinese medicinal composition. The Chinese medicinal composition is prepared from the following raw materials in portion by weight: 1 to 5 portions of rape pollen and 1 to 5 portions of wild chrysanthemum, wherein the optimal dose is based on the weight ratio of the rape pollen to the wild chrysanthemum of 1 to 1. The Chinese medicinal composition has quite remarkable effect of treating the prostatitis and the prostate hyperplasia. The preparation method can effectively extract effective components of the medicament, remove impurities and well exert medicinal effect.

The invention relates to a Chinese medicine for treating the systemic lupus erythematosus, particularly the lupus nephritis and a method for preparing the same. The medicine consists of the following components of oldenlandia diffusa, barbat skullcap, redroot gromwell, glutinous rehmannia, root of red-rooted salvia, motherwort and scorpion. The medicine has effects of clearing away the heat-evil and expelling superficial evils and activating blood circulation to dissipate blood stasis and is mainly used to treat the systemic lupus erythematosus, particularly the lupus nephritis; moreover, by matching Western medicines such as glucocorticoid and immunodepressant, etc., the medicine can be used to jointly treat the systemic lupus erythematosus, which can improve the effect of the hormone and the immunodepressant in curing the systemic lupus erythematosus, lower the incidence rate of infecting the complication, lower the recurernce rate and the death rate and have the important clinical meaning. The medicine of the invention can be made in all medicament forms for clinical use, including the powder, the medicinal broth, the mixture, the oral taking liquid, the capsule, the pelletized granule and the concentrated pill, etc.

The invention discloses mesenchymal stem cells and exosomes of the mesenchymal stem cell and application of the mesenchymal stem cells in treating anal fistula, and further discloses a method for treating anal fistula by using an autologous-fat-derived mesenchymal stem cell mixed preparation. The stem cell preparation includes autologous-adipose-derived mesenchymal stem cells (ADSCs) and exosomes(EXO-ADSCs) of the ADSCs, autologous platelet-rich plasma (PRP) and synthetic bacteriostatic peptides (AMP). The stem cells have immunoregulatory functions, the exosomes create a micro-environment which is conducive to recovery, meanwhile, the stem cells are stimulated to release various growth factors, and wound healing is promoted. PROP gel provides support and nutrients and works synergistically with stem cells, the survival rate after stem cell transplantation is improved, and the stem cells can better play a role. The synthetic peptides are single in components and controllable and reducethe incidence of infection. The combined use greatly improves the cure rate of anal fistula.

The invention obtains neodicoumarin compound that is 1,3-(6',6'',7',7''-tetramethoxy-8', 8''-dicoumarin)-acetone with immunologic suppression effect, in particular with induced specific immunologic tolerance effect that is extracted and separated from Honghuoma acetic ether extract, wherein the compound produces induced specific immunologic tolerance or achieve new balance effect for unbalanced immune system by inhibiting the multiplication of T lymphocyte, reducing the expression of intracellular transcription factor T-bet of dendritic cell (DC), inducing immature DC and adding the amount of T cells expressing Foxp3 regulation and can be used as an immunosuppressive agent, thereby being used for the treatment of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus.

The invention relates to the field of immunosuppressive drugs, in particular to application of IL-21 to prepare an immunosuppressor and a method for promoting a regulatory B cell (B10) to differentiate and IL-10 to secrete by IL-21. Related experimental results show that: IL-21 is mainly used for promoting IL-10 to secrete by inducing phosphorylation-STAT3 to activate; IL-10 generated by induction can inhibit proliferation of in-vitro T cells and has the immunosuppressive action; and IL-21 can be used as the cell factor of in-vitro amplification cells and can be further used for preparing drugs for treating autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, scleroderma and the like.

The invention relates to a composition and a method conducive to acquiring follicular regulatory T cells in vitro and an application of the composition. The invention proves that differentiation and number proliferation of in-vitro Tfr (follicular regulatory T cells) can be effectively induced by the aid of irritation of TGF (transforming growth factor)-beta, IL (interleukin)-2, anti-CD3 antibodies, anti-CD28 antibodies and baicalin, and expression of Foxp3 in the Tfr is facilitated. The Tfr cells amplified by the method can be used for treating autoimmune diseases and chronic inflammatory diseases, the autoimmune diseases include lupus erythematosus, dermatomyositis, vasculitides, sicca syndrome, scleroderma, rheumatoid arthritis, ankylosing spondylitis, disseminated sclerosis and autoimmune hepatitis, and the chronic inflammatory diseases include diabetes, coronary heart diseases, hyperlipemia, eczema, vitiligos, atopic dermatitis, lichen planus and the like.

The invention discloses a formula feed for treating gosling plague and a preparation method of the formula feed. The feed comprises the raw materials of corns, wheat, millet, glutinous rice, wheat bran, rapeseed meal, mung bean flour, lotus root starch, carrot, yam flour, bombyx batryticatus powder, corn oil, salt, vitamin premix, microelement premix, yeast powder, alfalfa meal, garlic powder, calcium hydrophosphate, limestone powder, triethylhexanoin and ammonium ferric citrate. The preparation method comprises the steps of preparing, crushing, burdening and granulating a traditional Chinese medicine additive. The formula feed has the beneficial effects that the formula feed is relatively short in treatment course, relatively good in curative effect, free of medicine residue and low in cost price; the traditional Chinese medicine additive is matched with other feed raw materials and interacts with the other feed raw materials, so that the gosling plague can be treated, the nutrient requirements of goslings can be met, the formula feed is especially suitable for the nutrient requirements of the goslings with the gosling plague, and a certain healthcare function on the organism can be achieved after a consumer eats the goose meat.

The invention provides a traditional Chinese medicine composition for relieving postoperative pain and accelerating wound healing, and relates to the technical field of traditional Chinese medicines.The traditional Chinese medicine composition comprises the following raw materials in parts by mass of 25-40 parts of ceratostigma willmottianum roots, 15-30 parts of scandent schefflera roots, 12-23parts of rhizoma bolbostemmae, 20-40 parts of halloysitum rubrum, 15-30 parts of ligusticum wallichii, 10-20 parts of caulis sinomenii, 3-9 parts of long peppers, 5-10 parts of radix sophorae flavescentis, 4-11 parts of camphortree leaves, 10-16 parts of divaricate saposhnikovia roots, 7-18 parts of swordlike atractylodes rhizomes, 4-10 parts of field thistle herbs, 5-20 parts of cyrtomium balansae rhizomes, 13-27 parts of slender dutchmanspipe roots, 20-30 parts of licorice roots and 6-15 parts of fructus aurantii. The traditional Chinese medicine composition can notably relieve postoperativepain and accelerate wound healing, is notable in treatment effects, is reasonable in formula of raw materials, is simple to prepare, and can be further prompted and applied.

The invention provides an application of hemin and/or hemin compounds thereof to preparation of medicines for preventing and treating rheumatoid arthritis. The hemin or the hemin compounds have remarkable effect of resisting inflammation when being used for performing in vitro action on macrophages, can effectively restrain vola swelling for a rat arthritis model, and can notably reduce expressionof metapodium inflammatory factor mRNA and mRNA expression of liver and spleen tissue autoimmunity correlation factors. The application explains that the hemin or the hemin compounds have good effectof preventing and treating rheumatoid arthritis.

The invention relates to a faded shewanella oneidensis LCT-SM262 strain in a space environment, and biological characteristics, a genomic deoxyribonucleic acid (DNA) sequence, a transcriptome and differential proteomics of the faded shewanella oneidensis LCT-SM262 strain, and in particular relates to a functional sequence and a molecule which are analyzed and identified through comparing with ground faded shewanella oneidensis. The mutant gene, differential expression gene and protein molecule of the faded shewanella oneidensis in the space environment can be comprehensively and accurately obtained, so that researches on the function and mechanism of the space environment on microorganisms are facilitated, and the safety of the space environment is guaranteed; novel toxicity and drug-resistant target spots can be conveniently found out, so that novel treatment target spots are provided for clinic infectious diseases; and a metabolic product-prodigiosin of the strain has functions of tumor resisting and immunosuppression and has a potential application prospect.

The invention provides a pyrrole sesquiterpene compound, a preparation method and uses thereof, and belongs to the field of medicine. According to the present invention, the pyrrole sesquiterpene compound has novel structure, has immunosuppressive action, can be used for preparing immunosuppressive agents, has broad application prospects, and has a structural general formula defined in the specification.