116results about How to "Long retention" patented technology

Disclosed are a variety of arcuate-shaped inserts for drill bits, and in particular, for placement in rolling cone cutters of drill bits. The arcuate inserts include 360° or ring-shaped inserts, as well as inserts of smaller arcuate length. The arcuate inserts are suitable for use in all surfaces of the rolling cone cutter, and in other locations in drill bits, and may have specialized cutting surfaces and material enhancements to enhance their cutting duty performance. Certain arcuate inserts may include stress relieving discontinuities such that, upon assembly into the cone or during drilling, the arcuate inserts may fragment in a controlled and predicted manner into shorter arcuate lengths.

The present application relates to optimized IgG immunoglobulin engineering methods for their generation, and their application, particularly for therapeutic purposes.

Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and / or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and / or the back of the eye.

Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and / or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and / or the back of the eye.

A cooling system for a turbine airfoil of a turbine engine has a multi-pass serpentine flow circuit providing a flow path from a forward cooling flow entry at the root and exhausting towards the trailing edge through a series of chord wise micro channels extending from the rearward pass of the multi-pass serpentine circuit to pressure side bleed slots, each having a forward pressure side lip and opening onto the pressure side adjacent the trailing edge. The micro channels can be formed by a series of spaced fins stacked span wise and extending between the outer wall on the pressure side and the outer wall on the suction side and extending chord wise from the rearward pass to the trailing edge. At least two trip strips can extend from sides of the fins into the micro channels and be staggered relative to trip strips extending into the micro channel from an adjacent fin, whereby turbulent flow levels in the micro channels are increased.

A method of baking bread in a high temperature bake oven, comprising initiating a heating element in a lower portion of the bake oven, locating the bread on a first pizza stone located above the heating element, directing circulating heated air in the oven with a baffle around the first pizza stone to between the first pizza stone and a second pizza stone located above the first pizza stone, and directing the circulating heated air in the oven rapidly from between the first and second pizza stones out of the oven through an opening in the front of the oven.

Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and / or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and / or the back of the eye.

Disclosed is a method of preparing a biocide having improved durability of its biocidal activity as well as disinfection efficiency at an initial stage, comprising the steps of: (a) preparing stabilized alkali or alkaline earth metal hypochlorite having a pH at least 11 by mixing a chlorine oxidant including alkali or alkaline earth metal hypochlorite with a stabilizer in an alkali solution; (b) preparing a bromide ion source; and (c) adding the bromide ion source prepared in step (b) into the stabilized alkali or alkaline earth metal hypochlorite prepared in step (a). Also, a method of controlling the growth of microorganisms using a biocide prepared by the method of the present invention is disclosed.

A network monitor that segments data packets at variable locations of data packets and stores a subset of the segments for troubleshooting or analysis. The network monitor selects data packets to be stored based on a set of user-defined classifier rules and discards other data packets. Each data packets selected for storage are analyzed up to an application protocol layer to determine start locations and / or end locations of data fields in the data packet. A set of user-defined slice rules are applied to each analyzed data packets to segment the data packets at the determined locations of the data fields. A subset of the data packet segments is stored in the network monitor. By storing relevant portions of data packets and discarding other portions of the data packets, the amount of data of data to be stored in the network monitor can be significantly reduced.

A method of baking bread in a high temperature bake oven, comprising initiating a heating element in a lower portion of the bake oven, locating the bread on a first pizza stone located above the heating element, directing circulating heated air in the oven with a baffle around the first pizza stone to between the first pizza stone and a second pizza stone located above the first pizza stone, and directing the circulating heated air in the oven rapidly from between the first and second pizza stones out of the oven through an opening in the front of the oven.

Methods for producing devolatilized and / or activated carbon in a reactor or reaction vessel of a heat treatment system from a suitable carbonaceous feedstock by introducing the feedstock into the reactor tangentially at a rotational velocity of at least 90 RPM. The methods include the steps of providing a combination of conveying means and a gas flow having various compositions and creating distinct carbonaceous feedstock material flow patterns and process conditions such that the feedstock is conveyed through the reactor or reaction vessel and heated via combustion, thereby producing activated carbon or other heat-treated carbons while concurrently avoiding adverse reaction conditions. Single and two-stage heat treatment systems may be used to heat a carbon feedstock, to which one or more industrial minerals may be added to co-produce compositions such as lime with the heat-treated carbon.

Ultrasound-assisted contactless stirring of liquids in a resonator cell by microparticles is achieved by repeated creating and destruction of nodal patterns associated with standing waves of various resonance frequencies causing continuous movements of microparticles inside the cell. Swept-frequency sonication methods include using constant or variable rate of frequency change as well as a stepwise change of frequency of the transducer within a predefined range. Other useful steps include initial detection of the set of resonance frequencies and periodic refreshing of that set. Control systems are described including means to automatically detect the resonance frequencies and maintain the operation of the transducer thereon. Advantageous designs of the apparatus are described for use in microstirring, mixing of liquids using magnetic microbeads, microbubbles, microtiter plates, microarray plates, etc.

An apparatus (1) for administering a gas to a person or an animal, is provided with a chamber (9) for receiving a quantity of gas to be administered. The chamber is provided with a gas line (3) for supplying gas from a source to the chamber (9) and elements for pressurizing the gas in the chamber. The chamber (9) is connected to a breathing tube (5) for supplying pressurized gas from the chamber (9) to the person or the animal, wherein the breathing tube (5) connects to a discharge channel (26), for discharging gas exhaled by the person or the animal, via a valve (11), which restricts the flow of exhaled gas from the breathing tube (5) to the discharge channel (26) in order to build up gas pressure in the breathing tube (5) during exhalation.

The use of macromonomers whichhave a glass transition temperature of at least 20° C.,have at least one oligomeric and / or polymeric structural unit which is incompatible with polyacrylates, andhave at least one polymerizable double bond in the form of a vinyl, acrylate and / or methacrylate unitas comonomers in the preparation of oriented polyacrylate pressure sensitive adhesives.

Methods for formulating a liposome comprised of a surfactant and a cryopreservative that can be frozen for long term stability, and upon thawing provides an immediate and sustained release delivery profile. Specific liposome formulations include anti-infectives and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.

A coupling device for equipment implements is described, which coupling device does not impair the lubricity of bearing sections when the equipment is in service, does not cause seizure during rotation of bearings, does not need frequent feeding of grease to the bearing sections from outside, and provides good noise absorbability. The coupling device has such a structure that a metal based contact material 7 capable of storing a lubricating oil and / or lubricant is interposed between an implement bushing 1 made from steel and implement pin 4 of an implement for construction equipment.

The present invention provides a mass spectrometry capable of high-efficiency and high-throughput ECD. An electron source and a two-dimensional combined ion trap in which a magnetic field along and generally parallel to a central axis is applied are used, thereby to achieve the foregoing object. First, precursor ions are trapped. By adopting the two-dimensional combined ion trap, it is possible to obtain a high ion trapping efficiency upon being injected and trapping. Subsequently, electrons are made incident thereon in such a manner as to be wound along the central axis to which no radio frequency is applied by using a magnetic field. For this reason, it is possible to allow energy-controlled electrons to reach the precursor ions. It is possible to implement a mass spectrometer capable of avoiding heating due to a radio frequency electric field, and effecting high-throughput / high-efficiency ECD.

The present invention provides a polyethylene glycol-conjugated erythropoietin (PEG-conjugated EPO) prepared by PEG conjugation on the lysine residue at position 52 of native erythropoietin (native EPO). In order to achieve more sustained efficacy without losing physiological activities of native EPO, a glycoprotein rich in sugar chains, there has been a need to develop a PEG-conjugated EPO with significantly sustained efficacy by introducing a controlled number of PEG molecules at controlled positions. This PEG-conjugated EPO addresses such a need and provides more sustained efficacy.

A wafer adapter for a chemical and mechanical polishing (CMP) machine. The adapter includes a retaining ring with multiple grooves formed on one surface of the ring and an inner circle for grasping just a wafer. The grooves have narrower openings at the outer and wider bottoms at the inner circle of the ring. The bottoms are apart from the inner circle with a circular wall. The adapter with wedged grooves served as slurry pools has been proved to have higher polishing efficiency, no wafer lose by sharp edges collision on the wall and less contact pressure between the wafer and the adapter to extend the lifetime of the adapter.

A substrate treatment method for treating a substrate including a first silicon nitride film provided on a front surface thereof and a silicon oxide film provided on the first silicon nitride film to remove the first silicon nitride film and the silicon oxide film from the substrate includes: a first phosphoric acid treatment step of supplying a phosphoric acid aqueous solution having a predetermined first concentration to the substrate held by a substrate holding unit to treat the substrate with the first concentration phosphoric acid aqueous solution for the removal of the first silicon nitride film; and a second phosphoric acid treatment step of supplying a phosphoric acid aqueous solution having a second concentration lower than the first concentration to the substrate to treat the substrate with the second concentration phosphoric acid aqueous solution for the removal of the silicon oxide film after the first phosphoric acid treatment step.

A device for dispensing into the flushing water and / or for mixing with the flushing water detergent and / or sanitizing and / or deodorant products, in toilet bowls or hydraulic and sanitary fixtures in general. The device comprises a supporting structure provided with engagement means which can engage the hydraulic and sanitary fixture in order to support the supporting structure in a region of the fixture that is affected by the flushing water flow. The supporting structure supports rotatably, about a rotation axis, at least one rotating element, which interacts with the flow of flushing water in order to mix detergent and / or sanitizing and / or deodorant products introduced in the flushing water and / or adjust the dispensing of detergent and / or sanitizing and / or deodorant products connected to the supporting structure and / or vary the orientation of the flow of flushing water conveyed onto detergent and / or sanitizing and / or deodorant products connected to the supporting structure. The detergent and / or sanitizing and / or deodorant products are external to the rotating element.

In a method for manufacturing a single electron memory device including a single electron storage element in a gate lamination pattern formed on a nano-scale channel region of a MOSFET, formation of the gate lamination pattern includes sequentially forming a lower layer and a single electron storage medium for storing a single electron tunneling through the lower layer on a substrate, forming an upper layer including a plurality of quantum dots on the single electron storage medium, forming a gate electrode layer on the upper layer to be in contact with the plurality of quantum dots, and patterning the lower layer, the single electron storage medium, the upper layer, and the gate electrode layer, in reverse order.

Ultrasound-assisted contactless stirring of liquids in a resonator cell by microparticles is achieved by repeated creating and destruction of nodal patterns associated with standing waves of various resonance frequencies causing continuous movements of microparticles inside the cell. Swept-frequency sonication technique includes using constant or variable rate of frequency change as well as a stepwise change of frequency of the transducer within a predefined range. Other useful provisions include initial detection of the set of resonance frequencies and periodic refreshing of that set. Control systems are described including means to automatically detect the resonance frequencies and maintain the operation of the transducer thereon. Advantageous designs of the apparatus are described for use in microstirring, mixing of liquids using magnetic microbeads, microbubbles, microtiter plates, microarray plates, etc.

Disclosed is a method of preparing a biocide having improved durability of its biocidal activity as well as disinfection efficiency at an initial stage, comprising the steps of: (a) preparing stabilized alkali or alkaline earth metal hypochlorite having a pH at least 11 by mixing a chlorine oxidant including alkali or alkaline earth metal hypochlorite with a stabilizer in an alkali solution; (b) preparing a bromide ion source; and (c) adding the bromide ion source prepared in step (b) into the stabilized alkali or alkaline earth metal hypochlorite prepared in step (a). Also, a method of controlling the growth of microorganisms using a biocide prepared by the method of the present invention is disclosed.

A diamond impregnated drill bit features layered encapsulation of the diamond grit where the innermost layer is hardest or most abrasion resistant while succeeding layers are generally softer and less wear resistant. This can be accomplished by manipulating several variables in the encapsulation layers such as particle size or hard particle concentration. The outer layers can have added binder to make them softer. The encapsulated grit can be sintered or pre-sintered to make it less friable when handled.

A control device and a method for monitoring wear parts for printers and copiers is provided. The control device includes a counter device with which the replacement intervals or, respectively, the maintenance intervals for individual wear parts are monitored. The replacement and maintenance intervals can be individually set, so that they can be matched to the respective use conditions of the printer.

The present invention provides a holographic recording medium comprising: an optical recording layer, which optical recording layer includes one of a polymer compound having photoisomerizable groups in the side chain thereof and a polymer compound in which photoisomerizable molecules are dispersed therein, which recording layer records a hologram by having optical anisotropy induced by irradiation with a writing light having a predetermined wavelength thereon; and an optical filter layer formed on at least one side of the optical recording layer, which optical filter layer allows transmission of the writing light and a reading light having a predetermined wavelength irradiated on the optical recording layer, for reproducing the hologram recorded on the optical recording layer, therethrough and blocks light having a shorter wavelength than the wavelength of the writing light.

The present invention provides a mass spectrometry capable of high-efficiency and high-throughput ECD. An electron source and a two-dimensional combined ion trap in which a magnetic field along and generally parallel to a central axis is applied are used, thereby to achieve the foregoing object. First, precursor ions are trapped. By adopting the two-dimensional combined ion trap, it is possible to obtain a high ion trapping efficiency upon being injected and trapping. Subsequently, electrons are made incident thereon in such a manner as to be wound along the central axis to which no radio frequency is applied by using a magnetic field. For this reason, it is possible to allow energy-controlled electrons to reach the precursor ions. It is possible to implement a mass spectrometer capable of avoiding heating due to a radio frequency electric field, and effecting high-throughput / high-efficiency ECD.

The present invention relates to novel catalysts for oxidative esterification, by means of which, for example, (meth)acrolein can be converted to methyl (meth)acrylate. The catalysts of the invention are especially notable for high mechanical and chemical stability even over very long periods. This especially relates to an improvement in the catalyst service life, activity and selectivity over prior art catalysts which lose activity and / or selectivity relatively quickly in continuous operation in media having even a small water content.