70results about How to "Neutralize effect" patented technology

Disclosed is an anti-orthopoxvirus recombinant polyclonal antibody comprising distinct members which in union are capable of binding at least three orthopoxvirus related antigens, a pharmaceutical composition comprising the antibody, and a method for its production. Also disclosed is a polyclonal cell line capable of producing the recombinant polyclonal antibody as therapeutic methods utilizing the polyclonal antibody. Finally, the invention also pertains to a method for screening for useful V_H and V_L pairs useful when preparing the polyclonal antibody.

In the case of a fitting for a vehicle seat, in particular for a motor vehicle seat, having a first fitting part (11), a second fitting part (12) connected by a gear mechanism to the first fitting part (11), a driving ring (26), which at least partially defines an eccentric (27, 29) and is mounted rotatably in the first fitting part, for driving a rolling movement of the second fitting part (12) on the first fitting part (11), and a drivable driving bushing (21) which is mounted rotatably, the driving bushing (21) and the driving ring (26) are connected to each other in a form-fitting manner by a transmission profile (24′, 26′).

The invention relates to monoclonal antibodies capable of recognizing and neutralizing epitopes from the ligand domain, the translocation domain or the catalytic domain of the enterotoxin (toxin A) and cytotoxin (toxin B) from Clostridium difficile, as well as their production and therapeutic and prophylactic applications to diseases caused by said toxins.

The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example misfolded proteins like amyloid B and advanced glycation-end-products.

Shoe soles with and without removable/replaceable gripping pods for athletic or sport shoes are provided with enhanced traction. The sole portions or gripping pods may be provided with a supply of a substance that exhibits a tackiness for enhancing friction between the shoe sole and the any hard floor. The tackiness-enhancing substance may be time-released or discharged from within the shoe sole onto the lower surface(s) of the sole that make(s) contact with the smooth hard playing surface or may be in response to compression or shear forces acting on the sole during play to prolong the tacky properties and reduce slippage. A visual indicator may be provided for notifying the player that it is time to replace the worn or used pod and insert a fresh pod or insert into the pod(s) to maintain high levels of gripping.

Production of aquaculture water for marine fauna and flora, prepared by seawater disinfected by electrolysis in an electrolytic treatment system and neutralized with a neutralization agent to eliminate deleterious effects to growth of microalgae.

The present invention relates to methods of treating proliferative disorders, particularly immunoproliferative disorders such as NK-type LDGL, and methods of producing antibodies for use in therapeutic strategies for treating such disorders. Generally, the present methods involve the use of antibodies that specifically bind to receptors present on the surface of the proliferating cells underlying the disorders.

This invention teaches a new class of materials that can be used to manufacture hairsprings and/or other components of mechanical watches, and methods for manufacturing these components. The new class of materials is crystalline compounds, including, but not limited to, gallium arsenide, extrinsically doped gallium arsenide, extrinsically doped silicon, gallium nitride, extrinsically doped gallium nitride, gallium phosphide, extrinsically doped gallium phosphide, and quartz. This invention also teaches laminated/coated crystalline compounds. The lamination/coating may be applied by one of the following methods, including but not limited to: plasma enhanced chemical vapor deposition, atomic layer deposition, sputtering, electron beam evaporation, and thermal evaporation. Using crystalline compounds, in particular extrinsically doping the crystalline compounds, affords the possibility to controllably alter the mechanical, electrical, thermal, magnetic, and/or other properties of the watch components. These properties can be further altered by applying single or multiple laminates/coatings of varying thicknesses and/or geometries.

The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.

Window pane systems which offer improved protection against blast and impact hazards, including contact blast caused by a bomb or a shell, with or without hollow charge and bullets. A window pane system of the present invention includes multiple glass layers, to absorb the ballistic impact of the explosion; a thick polymer such as polycarbonate, to absorb the kinetic energy of the blast including contact blast; and multiple elastic thin layers of polymer such as polycarbonate, to absorb the blast impact such as the shock wave and shrapnel. Optionally, the last layer is extended such that the last layer is covering up to the full width of the window pane system, preferably in all four sides of the window pane system.

A roll-off piston is made of plastic for an air spring rolling-lobe flexible member. The roll-off piston and the air spring rolling-lobe flexible member are arranged between a sprung mass and an unsprung mass. The roll-off piston includes a first piston part; a second piston part connected to the first piston part; and, the first and second piston parts being made of a layered composite material of alternating layers of plastic and elastomeric material.

The present invention provides a method and device for detecting estrus in animal by sensing along time the motion of the animal and identifying when the sensed motion is not related to eating periods of the animal. Based on the sensed motion which is not related to eating periods the estrus in the animal is identified.

The present invention related to a method and therapeutic composition for the treatment of coagulation disorders comprising administration of a lipoprotein associated coagulation inhibitor.

A computer-implemented method and system determines camera movement of a new frame relative to a sequence of frames of images containing at least one dynamic object and for which relative camera movement is assumed. From changes in color values of sets of pixels in different frames of the sequence for which respective locations of all pixels in each set are adjusted so as to neutralize the effect of camera movement between the respective frames in the sequence containing the pixels, corresponding color values of the pixels in the new frame are predicted and used to determine camera movement as a relative movement of the new frame and the predicted frame. An embodiment of the invention maintains an aligned space-time volume of frames for which camera movement is neutralized and adds each new frame to the aligned space-time volume after neutralizing camera movement in the new frame.

The invention relates to a method of magnetic resonance (MR) imaging of at least a portion of a body (10) placed in a stationary and substantially homogeneous main magnetic field. The method comprises the following steps; —exciting nuclear magnetization selectively within a spatially restricted volume of interest (20) by subjecting the portion to an imaging sequence (IMG) comprising at least one RF pulse (α) and switched magnetic field gradients (GX/GY); —acquiring at least one MR imaging signal from the volume of interest (20); —exciting nuclear magnetization within a spatially restricted navigator volume (21) by subjecting said portion to a navigator sequence (NAV) comprising at least one RF pulse and switched magnetic field gradients, wherein the navigator volume (21) at least partially overlaps with the volume of interest (20); —acquiring at least one MR navigator signal from said navigator volume (21); —reconstructing a MR image from the acquired MR imaging signals. It is an object of the invention to enable MR imaging with reliable motion detection and high image quality. For this purpose, the invention proposes that the nuclear magnetization within the volume of interest (20) is transformed back into longitudinal magnetization prior to application of the navigator sequence (NAV) by subjecting said portion to an unlabeling sequence(UNLBL) comprising at least one RF pulse (−α).

Method for producing an aqueous suspension, which is based on a hydraulic binder, and a hardened binder product. According to the invention, a composition of blending agents is added in the aqueous phase into the binder, which composition comprises calcium carbonate particles having an average particle size of 2-200 nm, in order to generate an aqueous suspension and, if needed, mineral fillers are added into this suspension, in order to produce a hardening plaster or concrete mixture. Besides calcium carbonate, the composition of blending agents can comprise calcium hydrogen carbonate and meta-kaolin sinter, too. By using the present invention, it is possible to improve the properties of products which are bound by hydraulic binders; with the described combination of blending agents it is possible to affect for instance the early strength, the frost resistance, the phenomenon of bleading, the plasticizing, the size of the transition zone and the durability of concrete or plaster, and to reduce the quantity of the hydraulic binder.

An apparatus for the production of particles of a substance by dynamic precipitation of the substance from a fluid solution containing the substance dissolved in a fluid solvent. The apparatus is characterized by comprising A) a first main flow line FL1 (1) intended for a first pressurized fluid F1 and encompassing in its downstream part (dFL1) (38) one, or more dFL1 sub-lines (1a,b,c), where a) every dFL1 subline • comprises one or two serially linked flow-through dispensers for F1 (5a,b,c. and 6a, b, c) and • is functionally equal to the other dFL1 sublines, and b) each of the dispensers • has an inlet (7a,b,c. and 8a,b,c, respectively) and an outlet (9a,b,c. and 1 Oa,b,c . . . , respectively) for flow, and • is functionally equal with the corresponding dispensers in the other dFL1 sublines, and B) a particle formation arrangement (4) comprising a) one or more flow-through particle formation chambers (3a,b,c . . . ), and b) the downstream dispensers (5a,b,c.) of said one or two dispensers (5a,b,c . . . ,6a,b,c.) with one, two or more dispensers per chamber, at least one of the one or two dispensers (5a,b,c . . . ,6a,b,c.) is an injector which is capable of being repeatedly activated enabling a pulsed flow through the outlet of the injector.

The invention relates to a method and a system for restoring domain management for a domain (108) in which content access rights are shared between one or more devices (106, 110, 112, 118, 122, 124), wherein the domain management was executed by a first domain management device (106) and is discontinued by this first domain management device (106). The first domain management device (106) registers one or more characteristics of the domain (108) at a domain registration server (114). After discontinuation of the domain management by the first domain management device (106), a second domain management device (118) sends a request to the domain registration server (114) for obtaining the right to manage the domain (108). The domain registration server (114) provides the right to manage the domain (108) together with at least one of the one or more registered characteristics of the domain (108). The invention further relates to a domain registration server (114) and a domain management device (106, 118) for use in the system for restoring domain management.

The object of the present invention is to provide a tablet manufacturing method and also to provide a tablet such as a carbonated spring bathing liquid in which although an aqueous solution after dissolution of the tablet becomes neutral in pH, neutralization reactions are allowed to take place efficiently and intensively inside the tablet, bubbles of carbon dioxide gas which are small in size as much as possible are continuously generated for a certain period of time, thereby the thus generated carbon dioxide gas is mostly dissolved in water without escaping into the air to increase concentrations of total carbonate components in water, and carbon dioxide gas in contact with the skin is designed to be easily converted to bicarbonate ions due to a pH value of the aqueous solution thereof and, therefore, absorbed through the skin, and this subject is solved by a tablet manufacturing method for conducting compression molding in the presence of an organic acid in a range of 1:10 to 1:3 and polyethylene glycol in a range of 1:100 to 1:5 in relation to bicarbonate (sodium hydrogen carbonate or potassium hydrogen carbonate), in which the tablet is subjected to compression molding so that an aqueous solution after dissolution of the tablet is from 5.5 to 8.5 in pH and the tablet is 15 kg or more in hardness and the tablet is also 7 mm or more both in diameter and thickness.