71results about How to "Neutralize effect" patented technology

Disclosed is an anti-orthopoxvirus recombinant polyclonal antibody comprising distinct members which in union are capable of binding at least three orthopoxvirus related antigens, a pharmaceutical composition comprising the antibody, and a method for its production. Also disclosed is a polyclonal cell line capable of producing the recombinant polyclonal antibody as therapeutic methods utilizing the polyclonal antibody. Finally, the invention also pertains to a method for screening for useful VH and VL pairs useful when preparing the polyclonal antibody.

In the case of a fitting for a vehicle seat, in particular for a motor vehicle seat, having a first fitting part (11), a second fitting part (12) connected by a gear mechanism to the first fitting part (11), a driving ring (26), which at least partially defines an eccentric (27, 29) and is mounted rotatably in the first fitting part, for driving a rolling movement of the second fitting part (12) on the first fitting part (11), and a drivable driving bushing (21) which is mounted rotatably, the driving bushing (21) and the driving ring (26) are connected to each other in a form-fitting manner by a transmission profile (24′, 26′).

The invention relates to monoclonal antibodies capable of recognizing and neutralizing epitopes from the ligand domain, the translocation domain or the catalytic domain of the enterotoxin (toxin A) and cytotoxin (toxin B) from Clostridium difficile, as well as their production and therapeutic and prophylactic applications to diseases caused by said toxins.

A pair of dual complementary optics having a first lens and a second lens wherein the first lens has a gradient of a multiplicity of bands, the uppermost series of bands having a primary color embedded therein and the lowermost series of bands having a complementary secondary color embedded therein, the second lens having the inverse color embedded therein so that a primary color in the first lens is aligned with a secondary color in the second lens and a secondary color in the first lens is aligned with a primary color in the second lens. The color correction units are created such that the uppermost band has the largest amount of color correction units gradually decreasing to the lowermost band of the same color having the least amount of color correction units and thereafter, the second lower color has the lowest amounts of color correction units in the uppermost band of the secondary color gradually increasing to the greatest amount of color correction units in the secondary color in the lowermost band with the inverse in the second lens so that the lens is darkest on top and on the bottom and is lightest in the middle. Each lens is capable of either transmitting more than fifty percent of visible light in both wavelength ranges 400–550 nm and 550–750 nm or is capable of transmitting less than fifty percent of the visible length in both wavelength ranges 400–500 nm and 550–750 nm.

The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example misfolded proteins like amyloid B and advanced glycation-end-products.

The invention provides improved nucleic acid ligands that inhibit coagulation and improved modulators of the nucleic acids to provide ideal modulators of coagulation. These improved nucleic acids and modulators are particularly useful for inhibiting coagulation in a host undergoing a therapeutic regime such as surgery or coronary artery bypass.

Production of aquaculture water for marine fauna and flora, prepared by seawater disinfected by electrolysis in an electrolytic treatment system and neutralized with a neutralization agent to eliminate deleterious effects to growth of microalgae.

Method for producing an aqueous suspension, which is based on a hydraulic binder, and a hardened binder product. According to the invention, a composition of blending agents is added in the aqueous phase into the binder, which composition comprises calcium carbonate particles having an average particle size of 2-200 nm, in order to generate an aqueous suspension and, if needed, mineral fillers are added into this suspension, in order to produce a hardening plaster or concrete mixture. Besides calcium carbonate, the composition of blending agents can comprise calcium hydrogen carbonate and meta-kaolin sinter, too. By using the present invention, it is possible to improve the properties of products which are bound by hydraulic binders; with the described combination of blending agents it is possible to affect for instance the early strength, the frost resistance, the phenomenon of bleading, the plasticizing, the size of the transition zone and the durability of concrete or plaster, and to reduce the quantity of the hydraulic binder.

The invention provides improved nucleic acid ligands that inhibit coagulation and improved modulators of the nucleic acids to provide ideal modulators of coagulation. These improved nucleic acids and modulators are particularly useful for inhibiting coagulation in a host undergoing a therapeutic regime such as surgery or coronary artery bypass.

This invention teaches a new class of materials that can be used to manufacture hairsprings and / or other components of mechanical watches, and methods for manufacturing these components. The new class of materials is crystalline compounds, including, but not limited to, gallium arsenide, extrinsically doped gallium arsenide, extrinsically doped silicon, gallium nitride, extrinsically doped gallium nitride, gallium phosphide, extrinsically doped gallium phosphide, and quartz. This invention also teaches laminated / coated crystalline compounds. The lamination / coating may be applied by one of the following methods, including but not limited to: plasma enhanced chemical vapor deposition, atomic layer deposition, sputtering, electron beam evaporation, and thermal evaporation. Using crystalline compounds, in particular extrinsically doping the crystalline compounds, affords the possibility to controllably alter the mechanical, electrical, thermal, magnetic, and / or other properties of the watch components. These properties can be further altered by applying single or multiple laminates / coatings of varying thicknesses and / or geometries.

A pair of dual complementary optics having a first lens and a second lens wherein the first lens has a gradient of a multiplicity of bands, the uppermost series of bands having a primary color embedded therein and the lowermost series of bands having a complementary secondary color embedded therein, the second lens having the inverse color embedded therein so that a primary color in the first lens is aligned with a secondary color in the second lens and a secondary color in the first lens is aligned with a primary color in the second lens. The color correction units are created such that the uppermost band has the largest amount of color correction units gradually decreasing to the lowermost band of the same color having the least amount of color correction units and thereafter, the second lower color has the lowest amounts of color correction units in the uppermost band of the secondary color gradually increasing to the greatest amount of color correction units in the secondary color in the lowermost band with the inverse in the second lens so that the lens is darkest on top and on the bottom and is lightest in the middle. Each lens is capable of either transmitting more than fifty percent of visible light in both wavelength ranges 400-550 nm and 550-750 nm or is capable of transmitting less than fifty percent of the visible length in both wavelength ranges 400-500 nm and 550-750 nm.

The present invention is related to chimeric and humanized antibody and to methods and compositions for the therapeutic and diagnostic use in the treatment of amyloidosis, a group of disorders and abnormalities associated with amyloid protein such as Alzheimer's disease.

A method and a system for monitoring and training attention real-time attentional bias by applying at least one sensory stimulus over a human subject, using at least one stimulation device, where the sensory stimuli is associated with at least one attentional bias; calculating at least one real-time attention bias score of the subject by measuring response of the subject to the respective applied sensory stimulus; and outputting attentional feedback in real-time indicative of the calculated real-time attentional bias score. The feedback is outputted in real-time or near real-time, using one or more output devices for outputting the attention feedback such as visual or auditory output devices.

A low noise RF mixer is described. The mixer of the present invention has excellent linearity due to reduction of second-order distortion. The mixer includes an inputting stage, a switching stage and a load stage. The inputting stage includes a switching pair and a transconductance circuit. The load stage is formed by resistors. The switching stage includes a switch quad (two switch pairs). Each switch pair of the switching stage has a current source for implementation of current injection to a common source (emitter) junction of the switch pair. For each switch pair of the switching stage, an inductor is connected between the current source and the common source (emitter) junction. In addition, a capacitor is connected with the inductor.

Window pane systems which offer improved protection against blast and impact hazards, including contact blast caused by a bomb or a shell, with or without hollow charge and bullets. A window pane system of the present invention includes multiple glass layers, to absorb the ballistic impact of the explosion; a thick polymer such as polycarbonate, to absorb the kinetic energy of the blast including contact blast; and multiple elastic thin layers of polymer such as polycarbonate, to absorb the blast impact such as the shock wave and shrapnel. Optionally, the last layer is extended such that the last layer is covering up to the full width of the window pane system, preferably in all four sides of the window pane system.

A roll-off piston is made of plastic for an air spring rolling-lobe flexible member. The roll-off piston and the air spring rolling-lobe flexible member are arranged between a sprung mass and an unsprung mass. The roll-off piston includes a first piston part; a second piston part connected to the first piston part; and, the first and second piston parts being made of a layered composite material of alternating layers of plastic and elastomeric material.

The present invention related to a method and therapeutic composition for the treatment of coagulation disorders comprising administration of a lipoprotein associated coagulation inhibitor.

A computer-implemented method and system determines camera movement of a new frame relative to a sequence of frames of images containing at least one dynamic object and for which relative camera movement is assumed. From changes in color values of sets of pixels in different frames of the sequence for which respective locations of all pixels in each set are adjusted so as to neutralize the effect of camera movement between the respective frames in the sequence containing the pixels, corresponding color values of the pixels in the new frame are predicted and used to determine camera movement as a relative movement of the new frame and the predicted frame. An embodiment of the invention maintains an aligned space-time volume of frames for which camera movement is neutralized and adds each new frame to the aligned space-time volume after neutralizing camera movement in the new frame.

The invention provides improved nucleic acid ligands with enhanced stability that inhibit coagulation and improved modulators of the nucleic acids to provide ideal modulators of coagulation. These improved nucleic acids and modulators are particularly useful for inhibiting coagulation in a host undergoing a therapeutic regime such as surgery or coronary artery bypass.

The invention relates to a method of magnetic resonance (MR) imaging of at least a portion of a body (10) placed in a stationary and substantially homogeneous main magnetic field. The method comprises the following steps; —exciting nuclear magnetization selectively within a spatially restricted volume of interest (20) by subjecting the portion to an imaging sequence (IMG) comprising at least one RF pulse (α) and switched magnetic field gradients (GX / GY); —acquiring at least one MR imaging signal from the volume of interest (20); —exciting nuclear magnetization within a spatially restricted navigator volume (21) by subjecting said portion to a navigator sequence (NAV) comprising at least one RF pulse and switched magnetic field gradients, wherein the navigator volume (21) at least partially overlaps with the volume of interest (20); —acquiring at least one MR navigator signal from said navigator volume (21); —reconstructing a MR image from the acquired MR imaging signals. It is an object of the invention to enable MR imaging with reliable motion detection and high image quality. For this purpose, the invention proposes that the nuclear magnetization within the volume of interest (20) is transformed back into longitudinal magnetization prior to application of the navigator sequence (NAV) by subjecting said portion to an unlabeling sequence(UNLBL) comprising at least one RF pulse (−α).

Method for producing an aqueous suspension, which is based on a hydraulic binder, and a hardened binder product. According to the invention, a composition of blending agents is added in the aqueous phase into the binder, which composition comprises calcium carbonate particles having an average particle size of 2-200 nm, in order to generate an aqueous suspension and, if needed, mineral fillers are added into this suspension, in order to produce a hardening plaster or concrete mixture. Besides calcium carbonate, the composition of blending agents can comprise calcium hydrogen carbonate and meta-kaolin sinter, too. By using the present invention, it is possible to improve the properties of products which are bound by hydraulic binders; with the described combination of blending agents it is possible to affect for instance the early strength, the frost resistance, the phenomenon of bleading, the plasticizing, the size of the transition zone and the durability of concrete or plaster, and to reduce the quantity of the hydraulic binder.

An apparatus for the production of particles of a substance by dynamic precipitation of the substance from a fluid solution containing the substance dissolved in a fluid solvent. The apparatus is characterized by comprising A) a first main flow line FL1 (1) intended for a first pressurized fluid F1 and encompassing in its downstream part (dFL1) (38) one, or more dFL1 sub-lines (1a,b,c), where a) every dFL1 subline • comprises one or two serially linked flow-through dispensers for F1 (5a,b,c. and 6a, b, c) and • is functionally equal to the other dFL1 sublines, and b) each of the dispensers • has an inlet (7a,b,c. and 8a,b,c, respectively) and an outlet (9a,b,c. and 1 Oa,b,c . . . , respectively) for flow, and • is functionally equal with the corresponding dispensers in the other dFL1 sublines, and B) a particle formation arrangement (4) comprising a) one or more flow-through particle formation chambers (3a,b,c . . . ), and b) the downstream dispensers (5a,b,c.) of said one or two dispensers (5a,b,c . . . ,6a,b,c.) with one, two or more dispensers per chamber, at least one of the one or two dispensers (5a,b,c . . . ,6a,b,c.) is an injector which is capable of being repeatedly activated enabling a pulsed flow through the outlet of the injector.

The invention relates to a method and a system for restoring domain management for a domain (108) in which content access rights are shared between one or more devices (106, 110, 112, 118, 122, 124), wherein the domain management was executed by a first domain management device (106) and is discontinued by this first domain management device (106). The first domain management device (106) registers one or more characteristics of the domain (108) at a domain registration server (114). After discontinuation of the domain management by the first domain management device (106), a second domain management device (118) sends a request to the domain registration server (114) for obtaining the right to manage the domain (108). The domain registration server (114) provides the right to manage the domain (108) together with at least one of the one or more registered characteristics of the domain (108). The invention further relates to a domain registration server (114) and a domain management device (106, 118) for use in the system for restoring domain management.