A method for evaluate that comprehensive performance of a supercritical carbon dioxide cycle power generation system of a small lead-based reactor. Firstly, the basic operating parameters of the supercritical carbon dioxide (S-CO 2) cycle power generation system for lead-based reactor are determined. Subsequently, the modular design method is used to establish the sub-modules of turbomachinery work, heat transfer, heat exchanger pressure drop calculation, heat exchanger efficiency calculation, thermal analysis and economic analysis of power generation system. Then, the iterative calculation method is used to solve the heat exchanger pressure drop calculation and the thermodynamic analysis sub-module of the power generation system, and the thermal parameters of the power generation system and the unit power cost are obtained. Finally, based on multi-objective collaborative optimization, the thermal performance of power generation system is evaluated. Economy. This method can effectivelycomplete the new type of small-sized lead-based reactor S_Sco2 Design of Cycle Power Generation System, Thermodynamic, Heat Transfer and Economic Analysis Models for CO2 Cycle Power Generation Systems, Efficient System Heat Transfer-Economic performance analysis, solve the problem of automatic system design, complete the comprehensive performance comparison and guide the optimal S-CO2 Cycle PatternScreening.