The invention discloses a resource optimization method for physical layer resource minimization in Network Function Virtualization (NFV). The resource optimization method is as follows: an NFV architecture includes a logical layer, a virtual layer, a physical layer, and an MANO; the logical layer includes logical nodes and controllers; the physical layer includes physical nodes; the logical nodesand the controllers respectively send an information signal to a base station via corresponding physical nodes and an orthogonal channel; the base station calculates, based on the information signal,an effective load bit number, a channel used number, a transmitting power, a receiving signal-to-noise ratio, a throughput capacity and a total transmitted energy of each logical node and each controller; and when a third number, an effective load bit number, a receiving signal-to-noise ratio, a first throughput capacity, a second throughput capacity, a first total transmitted energy and a secondtotal transmitted energy meet corresponding requirements, and the logical nodes and the controllers meet an ultra reliable requirement, the MANO adaptively allocates transmitting powers and channel used numbers based on a hybrid optimization algorithm to minimize a physical layer resource.