The invention discloses a connecting structure of inclined strut prefabricated concrete pipe pile columns and a hollow floor or a flat slab. The connecting structure comprises an upper layer prefabricated concrete pipe pile column body, a lower layer prefabricated concrete pipe pile column body, inclined struts and the hollow floor/flat slab, the upper layer and lower layer prefabricated concrete pipe pile column bodies are formed by inserting connecting steel bars into prefabricated concrete pipe pile core holes and casting concrete in place, plate-column node areas are arranged between the upper layer and lower layer prefabricated concrete pipe pile column bodies and the hollow floor/flat slab, the connecting steel bars penetrate through the plate-column node areas to stretch into the upper layer and lower layer prefabricated concrete pipe pile column bodies for anchoring, the inclined struts are located between the two prefabricated concrete pipe pile column bodies on the same layer, and the two ends of the inclined struts are connected with the two plate-column joint areas located at the diagonal positions correspondingly. A prefabricated frame structure is reinforced by adding the inclined struts, the lateral load resistance of the structure is improved, and the anti-seismic property is improved; and plate-column joints are simple in structure, low in cost, convenient to construct, safe, reliable, high in construction efficiency and low in construction and installation fault tolerance rate.