A reaction unit for synthetic production of sebaconitrile comprises an ammoniating kettle, an ammonia cooler, a gas-liquid separator, a crude sebaconitrile receiving tank, a crude sebaconitrile conveying pump, a crude sebaconitrile distillation kettle, a crude sebaconitrile distillation column, a fine sebaconitrile cooler, a fine sebaconitrile receiving tank, a high-low boiling receiving tank and an evacuating system; the ammoniating kettle in the reaction unit allows full contact of reaction materials and allow reaction condition parameters, such as temperature and pressure, to be well adjusted, full ammoniating of the materials is guaranteed, the synthetic technique allows the materials to be fully and reasonably utilized in maximum extent, and the yield and purity of the finished sebaconitrile are guaranteed; the reaction unit for synthetic production of sebaconitrile is reasonable in layout, the technique is highly operable, the temperatures of the parts in the reaction unit, such as the ammoniating kettle and the crude sebaconitrile distillation kettle, are easy to adjust, the parts are convenient to operate, and the reaction unit has high overall recycling rate of materials, and has high production precision and quality.