31 results about "Aspartylglutamate" patented technology

This invention relates to novel α-conotoxin-like peptides comprising the following sequence of amino acids: Xaa1CCSXaa2Xaa3Xaa4CXaa5Xaa6Xaa7Xaa8Xaa9Xaa10Xaa11C—NH2 in which Xaa1 is G or D; Xaa3 is proline, hydroxyproline or glutamine; each of Xaa2 to Xaa8 and Xaa11 is independently any amino acid; Xaa9 is proline, hydroxyproline or glutamine; Xaa10 is aspartate, glutamate or γ-carboxyglutamate; Xaa11 is optionally absent; and the C-terminus is optionally amidated, with the proviso that the peptide is not α-conotoxin Ep1 or α-conotoxin Im1. The peptides are useful in the treatment or prevention of pain, in recovery from nerve injury, and in the treatment of painful neurological conditions such as stroke.

An amino acid composition comprises alanine, arginine, aspartic acid, glutamic acid, glycine, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, and glutamine. The amino acid composition of the present invention has such an effect that it can improve the action of promoting the process wherein the body fat is converted into the energy required for the physical exercise during and / or after the anoxic motions performed under an extremely high load.

The invention relates to soybean paste based on pre-fermentation and using Monascus purpureus as a dominant fungus symbiotic system, and a preparation method thereof, belonging to the technical fieldof seasoning preparation. According to the invention, soybeans are used as a raw material, three-stage fermentation is performed in virtue of a composite strain composed of Monascus purpureus TYQ017,Aspergillus oryzae 3.042, Actinomucor elegans, Aspergillus niger, Penicillium, Bacillus subtilis and Kluyveromyces marxianus, so the production of free amino acids is promoted, and the contents of aspartic acid, glutamic acid and threonine are increased; through combined usage of the Bacillus subtilis, the growth of dominant fungi is promote while the production of pathogens is inhibited; and through the introduction of the Kluyveromyces marxianus, the mellow flavor of the soybean paste is improved, and the soybean paste is allowed to be bright in color, soft and smooth in mouthfeel, rich in sauce flavor and delicious and lasting in aftertaste. The soybean paste is rich in monascorubin and lovastatin while retaining the nutrition of the soybean paste, has the effects of reducing cholesterol and preventing cardiovascular diseases; and the preparation method can improve productivity and shorten a production cycle, and has good social benefits.

The invention provides a bacterial strain Alicyclophilus sp.Ylb10 was deposited in the China Center for Type Culture Collection on August 7, 2020, with the deposit number CCTCC M 2020415, and the deposit address is China.Wuhan.Wuhan University. The application of the strain Ylb10 in remediating Cr(VI) heavy metal pollution and reducing Cr(VI) to Cr(III). The strain has good Cr(VI) reduction ability. When the concentration of Cr(VI) in the environment is 50 mg / L, 96.45% of Cr(VI) can be reduced within 18 hours. When the concentration of Cr(VI) in the environment was 200 mg / L, the reduction rate of Cr(VI) reached 99.06% in 60 hours. The optimum Cr(VI) reduction pH of this strain is 8~9, and the culture condition is static culture. The strain can utilize amino acids such as L-alanine, L-aspartic acid, L-glutamic acid, and L-serine, as well as organic acids such as α-hydroxy-butyric acid, L-lactic acid, propionic acid, and acetic acid. Ylb10 bacteria is an effective hexavalent chromium-reducing bacteria, which can be applied to the bioremediation of chromium-contaminated water samples and soil.

The present disclosure relates to an improved method for producing ergothioneine, comprising the steps of: (a) inoculating Pleurotus ostreatus strain CGMCC No.6232 into a seed medium, and culturing it to prepare a seed liquor, wherein the seed medium uses soybean cake powder as nitrogen source; and (b) inoculating the seed liquor into a fermentation basal medium, and then culturing it to obtain a fermentation broth of Pleurotus ostreatus mycelia. Further, any one or more members selected from NH4Cl, NH4NO3, NaCl, polyethylene glycol, folic acid, vitamin B1 (VB1), indolebutyric acid, citric acid, pyruvic acid, arginine, lysine, leucine, aspartic acid, glutamic acid, betaine, histidine, cysteine, methionine, tween, span, chitosan, Fluconazole, Miconazole, Ketoconazole, ethylenediaminetetraacetic acid (EDTA), isopropyl alcohol and dimethyl sulfoxide are added into the fermentation basal medium.

The invention discloses a method for synthesizing a cyclic dipeptide containing aspartic acid and glutamic acid. The method uses Fmoc-Asp(OtBu)-OH or Fmoc-Glu(OtBu)-OH as raw materials, and 9- Fluorenemethanol reaction to obtain the fluorenylmethyl ester of fully protected amino acid, and then remove the side chain tert-butoxy group to obtain the protected amino acid Fmoc-Asp-OFm or Fmoc-Glu-OFm; then use 2-CTC Resin resin as the carrier and Fmoc-Asp -OFm or Fmoc-Glu-OFm side chain γ-carboxyl linkage, solid-phase cyclization to synthesize a fully protected cyclic dipeptide, cleavage and cleavage to obtain a cyclic dipeptide with aspartic acid or glutamic acid at the carbon end. The method protects the carboxyl group by introducing 9-fluorenemethanol, which can be successfully removed during the solid-phase synthesis of dipeptide. The whole process is simple to operate, high in solid-phase cyclization efficiency, and high in purity. It is suitable for batch synthesis of asparagus Cyclic dipeptides of amino acid or glutamic acid.

The invention discloses a special feed helpful for improving the meat flavor of broilers. The feed is prepared from the following components in parts by mass: 5-10% of lysine, 1-5% of methionine, 2-10% of aspartic acid, 2-10% of glutamic acid, 5-20% of sodium chloride, 20-45% of calcium hydrogen phosphate, 10-30% of stone powder, 2-7% of multivitamin, 5-15% of multi-mineral, 0.5-1.5% of antioxidant, 0.2-1% of betaine, 0.5-1.5% of phytase, 1-2.5% of choline and 0.5-1.5% of essential oil. According to the special feed helpful for improving the meat flavor of broilers, a certain amount of organictrace elements are added into the formula, so that the feed can reduce the drip loss, abdominal fat percentage and fat deposition of chicken so as to improve the tenderness of the chicken, improve the quality of the chicken and finally improve the flavor of the chicken. A certain amount of vitamin E, vitamin C and biotin are added into the feed, so that the defense capability of poultry to external diseases can be enhanced, and the production performance of the broiler chicken can be improved.

Novel nucleoside derivatives represented by the following general formula (1): wherein X is(are) the same or different and each represents a pyrimidine or purine base or a derivative thereof, Y and Y′ are the same or different and each represents at least one amino acid or amino acid derivative selected from the group consisting of serine, threonine, ornithine, aspartic acid, glutamic acid, lysine, arginine, cysteine, methionine, δ-hydroxylysine, N-aminoethylglycine, N-aminoethylserine, N-aminoethyllysine, N-aminoethylornithine, N-aminoethylaspartic acid, N-aminoethylglutamic acid, homoglutamic acid, β-thiocarbonylaspartic acid, γ-thiocarbonylglutamic acid, and δ-thiocarbonylhomoglutamic acid, R1 represents a hydrogen atom or a hydroxyl group, A represents a single bond or a carbonyl or thiocarbonyl group, 1 is an integer of 0 to 5, and n is an integer of 1 to 100.

The invention provides a cyclic pentapeptide, the amino acid sequence of which is: cyclic-5-aspartic acid-glutamic acid-arginine-tyrosine-arginine. The cyclic pentapeptide inhibitor provided by the invention has good structural stability, can be efficiently combined with p7 channel protein, and effectively exerts the anti-hepatitis C virus effect.

The invention discloses a composite polymer colloid wound surface disinfectant containing amino acid and a preparation method of the disinfectant. The composite polymer colloid wound surface disinfectant takes polyvinylpyrrolidone and poloxamer as an emulsifier and a solubilizer, takes polyhexamethylene biguanidine, epsilon-polylysine, phenoxyethanol and water-insoluble chitosan with the degree of deacetyiation higher than 80% and the viscosity average molecular weight higher than 100,000 as bactericidal active ingredients and takes an aspartic acid, glutamic acid and cysteine mixture as a modifier and an reinforcing agent. The composite polymer colloid wound surface disinfectant is high in bactericidal capacity, high in acting speed, good in stability, safe and capable of promoting wound surface repair. The preparation method of the composite polymer colloid wound surface disinfectant comprises preparation of the chitosan solution, preparation of a polyhexamethylene biguanidine emulsion, preparation of a phenoxyethanol solution and compounding.

The present invention relates to novel liquid protein formulations, particularly arginine-free liquid pharmaceutical compositions of etanercept. The invention employs particular combinations and classes of buffer systems, tonicifiers, and sugar stabilisers, optionally alongside polar ionisable amino acids (e.g. aspartic acid, glutamic acid, histidine, and lysine), to afford a viable and storable drug product.

The invention belongs to the technical field of genetic engineering and enzyme engineering, and specifically relates to BmSPI39 mutant and application thereof. BmSPI39 is composed of the 25th to 98th positions in SEQ ID NO.1. The BmSPI39 mutant is the amino acid sequence of BmSPI39, as shown in SEQ ID NO.1, the alanine at the 56th position is mutated to arginine, Lysine, Serine, Threonine, Glutamine, Tyrosine, Methionine, Leucine, Aspartic Acid, Glutamic Acid, Histidine, Cysteine, Valine, Astragalus Paragine, Isoleucine, Phenylalanine, Tryptophan, Proline or Glycine. The BmSPI39 mutants of the present invention all have inhibitory activity on subtilisin and elastase, and when mutated to arginine or lysine, they also obtain trypsin inhibitory activity, and such mutants can be used to prepare trypsin inhibitors , the application prospect is good.

The invention discloses a submerged fermentation phellinus linteus mycelium glycoprotein, a usage and a separation extraction preparation method thereof, the complex is the complex of heteropolysaccharide and protein, wherein, the content of the heteropolysaccharide is 15 to 20 percent, and the heteropolysaccharide is composed of three monosaccharides of glucose monosaccharide, xylose and mannose; the content of the protein is 80 to 85 percent, and the protein is composed of 18 amino acids of aspartic acid, glutamic acid, arginine and so on; and the weight-average molecular weight is 20 to 40KD. The glycoprotein complex uses bran extract liquid as a main ingredient for preparing a culture medium, the phellinus linteus mycelium is produced by the submerged fermentation of the phellinus linteus bacterial strain liquid, the homogenization, the cold-water extraction, the centrifugalization, the collection of supernatant liquid, the precipitation of ammonium sulfate, the dialysis and the DEAE-Sepharose Fast Flow column chromatography are carried out for system separating and purifying the glycoprotein complex. The anti-bacterial glycoprotein is used for preparing the anti-bacterial dugs which have inhibitory effects on escherichia coil and staphylococcus aureus. At the same time, the glycoprotein complex can be used for the separation and the purification of the glycoprotein from the mycelium obtained by the submerged fermentation of various medical and edible fungi.