36 results about "Barbituric acid derivative" patented technology

The present invention relates to novel non-sedating barbituric acid derivatives, pharmaceutical compositions containing them and methods of neuroprotection in cases of cerebral ischemia, head trauma and other acute neurologic injuries, and prevention of resulting neuronal damage. The invention also relates to the use of non-sedating barbituric acid derivatives given in a manner and dosage effective to produce blood levels and brain levels of these drugs and / or their active metabolites sufficient to provide a therapeutic effect.

A method of treating movement disorders comprises administering to a human or animal subject in need of treatment a therapeutically effective amount of at least one compound according to the following formula: wherein R3 and R4 are each independently selected from the group consisting of lower alkyl, phenyl and lower alkyl substituted phenyl, and R1 and R2 are each independently either a hydrogen atom or a radical of the formula wherein R5 and R6 are each independently selected from the group consisting of H, lower alkyl, phenyl and lower alkyl substituted phenyl, its pharmaceutically acceptable salts, prodrugs, and metabolites thereof.

The present disclosure provides N-hydroxylamino-barbituric acid compounds of formulae (1)-(4), pharmaceutical compositions and kits comprising them, and methods of using such compounds or pharmaceutical compositions. The present disclosure provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

The present invention relates to a composition and a method of delivering a barbituric acid derivative to the central nervous system of a mammal in need of treatment for neurological conditions. In particular, the present invention relates to a method of administering an oral dosage form of a sodium salt of 5,5-diphenyl barbituric acid to enhance the bioavailability of 5,5-diphenyl barbituric acid and brain delivery of same.

A method of treating movement disorders comprises administering to a human or animal subject in need of treatment a therapeutically effective amount of at least one compound according to the following formula:wherein R3 and R4 are each independently selected from the group consisting of lower alkyl, phenyl and lower alkyl substituted phenyl, and R1 and R2 are each independently either a hydrogen atom or a radical of the formulawherein R5 and R6 are each independently selected from the group consisting of H, lower alkyl, phenyl and lower alkyl substituted phenyl, its pharmaceutically acceptable salts, prodrugs, and metabolites thereof.

A kit is provided based on two pastes designed to produce bone cement with high initial stability and therefore low post-cure. The kit includes a paste A and a paste B, wherein paste A contains (a1) a polymerizable monomer having a pH in water in the range of 5-9, (a2) a filling agent insoluble in (a1), and (a3) a barbituric acid derivative selected from the group consisting of 1,5-disubstituted barbiturates, 1,3,5-trisubstituted barbiturates, and 1,3,5-tetrasubstituted barbiturates, and paste B contains (b1) a polymerizable monomer having a pH in water in the range of 5-9, (b2) a filling agent insoluble in (b1), (b3) a peroxide soluble in (b1), (b4) a heavy metal compound insoluble in (b1) and selected from the group consisting of heavy metal salts and heavy metal complexes, and wherein at least one of the pastes A and B contains a halide salt.

To provide a polyamide resin composition containing an added crystal nucleator suitable for promoting the crystallization of a polyamide resin and not triggering discoloration in the resin, the polyamide resin composition being capable of raising the crystallization rate and achieving better molding process properties and heat resistance in comparison with the polyamide resin. A polyamide resin composition including a polyamide resin and a crystal nucleator comprising a carboxylic acid derivative represented by formula [1]. B1-L1-A-L2-B2 [1] (In the formula, A represents an optionally substituted C1-6 alkylene group or C6-10 divalent aromatic group, B1 and B2 represent optionally substituted C3-6 cycloalkyl groups or optionally substituted C6-10 aromatic groups, and L1 and L2 represent -C(=O)NR1- or -C(=O)O-.).

The present invention relates to novel non-sedating barbituric acid derivatives, pharmaceutical compositions containing them and methods of neuroprotection in cases of cerebral ischemia, head trauma and other acute neurologic injuries, and prevention of resulting neuronal damage. The invention also relates to the use of non-sedating barbituric acid derivatives given in a manner and dosage effective to produce blood levels and brain levels of these drugs and / or their active metabolites sufficient to provide a therapeutic effect.

The invention belongs to the technical field of synthetic chemistry, and particularly relates to a method for synthesizing a 5-substituted barbituric acid derivative under the catalysis of a rare earth chloride. The preparation method comprises: dissolving a halogenated hydrocarbon and 1,3-dimethyl barbituric acid in an organic solvent, carrying out a reaction for 6-10 h at a room temperature by using a rare earth chloride as a catalyst, and separating and purifying to obtain the 5-substituted barbituric acid derivative. According to the invention, the method has characteristics of simple andenvironmentally-friendly synthesis process, excellent selectivity, high yield and wide substrate range, and further has wide application value in the fields of biology, pharmaceutical chemistry industry and the like.

The invention relates to the field of oxidative synthesis, and in particular, relates to a 5-hydroxy-5-alkyl disubstituted barbituric acid derivative greenly synthesized by amine catalysis of air oxidation and a method thereof. The amine-catalyzed oxidation reaction of a 5-substituted 1,3-dimethylbarbituric acid derivative is studied; reaction catalysts and solvents are screened, hydroxylation ofalpha-C-H of 5-aryl or benzyl substituted barbituric acid compounds is found out to be realized through catalytic reaction under different conditions. The method has the following characteristics: (1)air is used as the source of hydroxyl functional groups, so the requirements of green development are met; (2) easily available and cheap alkali R3N rather than expensive metal catalysts is used; and(3) stoichiometric harmful phosphine compounds are prevented from being used as additives and reductants.

The invention provides barbituric acid derivatives and a preparation method thereof. The barbituric acid derivatives provided by the invention introduce fluorine atoms which have small radiuses and high electronegativity, and the bond energy of formed C-F bonds is higher than that of C-H bonds, thereby improving the stability and bioactivity of organic fluorine compounds; and the organic fluorinecompounds have relatively higher lipid solubility and relatively higher hydrophobicity. The barbituric acid derivatives provided by the invention introduce thiophene at the same time of introducing the fluorine atoms so as to achieve higher potential bioactivity and be easier to absorb. In-vitro antibacterial tests show that the compounds have a relatively better inhibiting effect on tested bacteria, and can be further developed as antibacterial agents or leading compounds. In the preparation method provided by the invention, a solvent-free one-step synthesis method is adopted; and the preparation method has the advantages of readily-available raw materials, simple operations, environmental-friendliness, high yield and the like.

The invention provides a barbituric acid derivative, a preparation method thereof, and an application of the derivative in data encryption and decryption. The chemical structure of the barbituric acidderivative is represented by formula I shown in the description. The barbituric acid derivative has the characteristic of crystallization-induced emission enhancement, and can be used for data encryption and decryption.

The present invention relates to a composition and a method of delivering a barbituric acid derivative to the central nervous system of a mammal in need of treatment for neurological conditions. In particular, the present invention relates to a method of administering an oral dosage form of a sodium salt of 5,5-diphenyl barburtic acid to enhance the bioavailability of 5,5-diphenyl barbituric acid and brain delivery of same.

The invention discloses a thiobarbituric acid derivative molecule modified molybdenum disulfide two-dimensional nano material with diversified hydrophilic and hydrophobic properties and charges, whichis a molybdenum disulfide nano material respectively modified by Ligand 1-Ligand 9 ligand molecular compounds shown as formulas (I) to (IX), and is sequentially named as MoS2 <-1>-MoS2 <-9>. The invention also discloses an application of the molybdenum disulfide nano material in preparation of drugs and drug carriers for inhibiting tumor cell growth, or in preparation of paclitaxel-loaded drug complexes for inhibiting tumor cell growth as a drug carrier. The experiments prove that the thiobarbituric acid derivative molecule modified molybdenum disulfide two-dimensional nano material with diversified hydrophilic and hydrophobic properties and charges is expected to become a potential drug or drug carrier for tumor synergistic treatment, and has broad scientific research and clinical application prospects.

The invention provides a green curable composition including a colorant in an amount of 47.5% by mass or more with respect to the total solid content of the green curable composition, the colorant containing a halogenated copper phthalocyanine pigment and a barbituric acid derivative yellow pigment at a ratio of from 6 / 4 to 3 / 7 (halogenated copper phthalocyanine pigment / barbituric acid derivative yellow pigment); a colored pattern formed from the green curable composition; a color filter including the colored pattern; a solid-state image sensor including the color filter; and a method of producing the color filter.

5-arylene barbituric acid derivatives, a preparing method thereof and a magnetic acidic nanometer material catalyst used for preparation of the derivatives are disclosed, and belong to the field of organic chemical synthesis. In a preparation reaction, the mole ratio of an aromatic aldehyde to barbituric acid or thiobarbituric acid is 1.0-1.4:1, the mole quantity of the catalyst is 7-12% of the mole quantity of the aromatic aldehyde, the volume in milliliter of water that is a reaction solvent is 4-7 times of the mole quantity in millimole of the aromatic aldehyde, the reaction temperature is 80-85 DEG C, and reaction time is 4-14 min. After the reaction is finished, the catalyst is adsorbed out with a magnet when the reaction solution is still hot, the rest reaction solution is cooled to room temperature and subjected to suction filtration, and filter dregs are washed with ethanol and dried in vacuum to obtain the 5-arylene barbituric acid derivatives. The derivatives, the method and the catalyst have characteristics of low catalyst loss, a high number of times of cyclic use, simple and convenient operation in a whole preparing process, a high greening degree, and the like and are convenient in industrial large-scale application.