7 results about "Barbituric acid derivative" patented technology

A dental ceramic blank comprising at least one organic compound, characterized in that the blank has an open-pore ceramic framework, wherein the open-pore ceramic framework is selected from an open-pore dental ceramic framework comprising zirconia, aluminum oxide, a mixed oxide comprising zirconia, and / or silicon carbide, wherein the open-pore ceramic framework contains 2 to 50 wt.% of at least one organic compound selected from a) comprising at least one polymerizable monomer and / or a mixture of polymerizable monomers, thermal initiators comprising peroxide and / or an azo compound or a redox system comprising a peroxide, and a reducing agent selected from ascorbic acid, an ascorbic acid derivative, barbituric acid or a barbituric acid derivative, sulfinic acid, a sulfinic acid derivative or a redox system (aa) barbituric acid or thiobarbituric acid or a barbituric acid or thiobarbituric acid derivative and (bb) at least one copper salt or copper complex and (cc) at least one compound with an ionic halogen atom, particularly preferably a redox system comprising 1-benzyl-5-phenylbarbituric acid, copper acetylacetonate and benzyldibutylammonium chloride, and / or b) a polymer of the aforementioned monomers polymerized in the blank with respect to the overall composition of the dental ceramic blank.

Provided herein are novel barbituric acid derivatives, their synthesis and use thereof in blocking leukocyte transmigration. The novel barbituric acid derivatives are useful for the treatment of disorders associated with leukocyte transmigration, such as for example inflammatory diseases and disorders, autoimmune diseases and disorders, and cancers.

This invention provides a 4-benzyloxyphenyl-substituted barbituric acid derivative and its preparation method, a flexible crystal of the 4-benzyloxyphenyl-substituted barbituric acid derivative and its preparation method and application, belonging to the field of organic optoelectronic materials technology. Under mechanical stimulation, the flexible crystal of the 4-benzyloxyphenyl-substituted barbituric acid derivative bends into a semi-ring without any breakage. After the mechanical force is removed, the crystal does not break or fracture and quickly returns to its original straight shape. This reversible bending-relaxation process can be repeated multiple times, highlighting its good elasticity and indicating that the flexible crystal of the 4-benzyloxyphenyl-substituted barbituric acid derivative possesses excellent mechanical properties.

The invention provides a 4-benzyloxybenzene substituted barbituric acid derivative and a preparation method thereof, a 4-benzyloxybenzene substituted barbituric acid derivative flexible crystal and a preparation method and application thereof, and belongs to the technical field of organic photoelectric materials. Under the stimulation of mechanical force, the 4-benzyloxybenzene substituted barbituric acid derivative flexible crystal is bent into a semi-ring without any fracture, and after the mechanical force is removed, the crystal is not fractured or fractured and quickly recovers to the original linear shape. The reversible bending-relaxation process can be repeated for multiple times, and the good elasticity of the flexible crystal is highlighted, which shows that the 4-benzyloxybenzene substituted barbituric acid derivative flexible crystal has excellent mechanical properties.

Provided herein are novel barbituric acid derivatives, their synthesis and use thereof in blocking leukocyte transmigration. The novel barbituric acid derivatives are useful for the treatment of disorders associated with leukocyte transmigration, such as for example inflammatory diseases and disorders, autoimmune diseases and disorders, and cancers.

The present invention relates to a spirocyclic barbituric acid derivative and a preparation method and application thereof. The present invention uses a tryptamine isonitrile derivative and an unsaturated barbituric acid derivative as reaction raw materials, and can achieve accurate synthesis of the spirocyclic barbituric acid derivative through a simple heating reaction. The preparation process of the spirocyclic barbituric acid derivative of the present invention is simple, the atom economy is high, and the post-processing is convenient. The obtained spirocyclic barbituric acid derivative has potential drug activity, shows significant inhibitory effects on a variety of cancer cells, and has broad application prospects in the preparation of anti-tumor drugs.