The invention provides a main control circuit of a centralized meter reading system. The main control circuit comprises a main chip, a power module, an SRAM (Static Random Access Memory) data storage module, a clock module, a man-machine operation interface, an SD (Secure Digital) card, an LCD (Liquid Crystal Display) liquid crystal display screen, a GPRS (General Packet Radio Service) wireless communication module, an MBUS (Meter-Bus) channel selection module, an MBUS communication module, a 485 communication module and an RS232 converter, wherein the power module is used for providing voltages. The communication modes of the main control circuit are optionally wireless and wired modes; the GPRS remote communication function is capable of providing reliable operations and high-efficiency operations for remote monitoring and operations; meanwhile, a concentrator and meters are connected in two manners of 485 and MBUS, and therefore, the main control circuit is simple and convenient in construction and good in compatibility with commercial heat meters; in addition, the MBUS communication module is matched with the MBUS channel selection module, and simultaneous working of a plurality of channels and district networking are realized by virtue of channel selection, and therefore, the market requirements are met to the utmost extent; the whole circuit is good in data acquisition effect and high in instantaneity and accuracy; besides, real-time reliable operations can be realized by use of the man-machine operation interface.