29 results about "Pancreatic Fluid" patented technology

The invention discloses a self-breaking outer drainage tube, and relates to the technical field of medical instruments, the self-breaking outer drainage tube comprises a tube body, and the tube body comprises a drainage part, a breaking part, a leading-out part and a puncture part; the drainage part and the fracture part are both made of degradable materials; the hole wall thickness of the circulation hole at the fracture part is smaller than the hole wall thickness of the circulation hole at the drainage part; during surgical operation, the degradable inner drainage part is placed in the pancreatic duct, the fracture part crosses the anastomotic stoma by 7-8 cm and crosses the biliary-intestinal anastomotic stoma, and the leading-out part walks in the enteric cavity to a proper position, penetrates out of the intestinal wall and is led out of the body through the abdominal wall. Cutting the puncture part to expose the outlet of the circulation hole, and discharging the body fluid through the circulation hole; after a certain period of time after the operation, the fracture part is automatically fractured under the action of pancreatic juice, the leading-out part is pulled out, the degradable drainage part continues to be degraded in the body and maintains the drainage function, and finally the drainage part is absorbed by the body or discharged out of the body without being taken out through the operation.

The present invention provides a material or method that can replace conventional materials and methods for preventing digestive fluid leakage. The digestive fluid leakage preventing material of the present invention comprises a self-assembling peptide gel, has an adhesion retention rate of at least 40% on a collagen sheet, and a decomposition rate of 35% or less based on pancreatic juice treatment at 37°C for 7 days.

The application relates to the embedding technical field, and particularly discloses a double emulsion gel bead embedding beta-carotene and probiotics and a preparation method thereof. The double emulsion gel bead comprises a composite layer, an oil phase and an inner water phase from outside to inside. The composite layer comprises an outer water phase and calcium alginate which are fused with each other. The outer water phase comprises a product after carrageenan and sodium caseinate are subjected to a Maillard reaction. The oil phase comprises beta-carotene, vegetable oil and a food emulsifier. The inner water phase comprises probiotics. In the gel bead, the beta-carotene and the probiotics are simultaneously embedded in the double emulsion gel bead, the calcium alginate hydrogel shell starts to decompose when entering the intestinal tract, then the double-layer emulsion is slowly decomposed after being subjected to chemical digestion of pancreatic juice, bile and small intestinal juice and mechanical digestion of the small intestine in the small intestine, and the beta-carotene and the probiotics are gradually released, the beta-carotene is converted into vitamin A in the intestinal tract and is absorbed, and the probiotics are delivered to the colon to play a probiotic effect.

The invention belongs to the field of biomedical materials, and particularly relates to an inner drainage end-by-end reducer tube based on the electrostatic spinning technology and a preparation method thereof.The inner drainage end-by-end reducer tube comprises an end-by-end reducing drainage tube, the whole drainage tube is of a hollow conical tubular structure, and the surface of the drainage tube is provided with regularly-arranged thread structures; the invention further provides a preparation method of the inner drainage end-by-end reducer pipe. The defects of existing internal drainage are overcome, and the natural anatomical form of the pancreatic duct is complied with by means of the drainage tube with the diameter changed end by end; the drainage tube is provided with a surface thread structure, and by matching with the swelling characteristic of a biodegradable material, the friction force between the drainage tube and the pancreatic duct wall is increased, and the probability of displacement of the drainage tube due to intestinal tract movement or pancreatic juice scouring is reduced.

The utility model provides a hepatopancreatic ampulla metabolism device which comprises a main drainage tube, a branch drainage tube is connected to the main drainage tube, a medicine release mechanism is arranged at the position, close to the inlet end, of the tube wall of the main drainage tube, and protrusions are arranged on the tube wall of the main drainage tube. The main drainage tube and the branch drainage tube are arranged to drain bile and pancreatic juice at the hepatopancreatic ampulla, discharge blocking of the bile and the pancreatic juice caused by abnormal metabolism at the hepatopancreatic ampulla is avoided, the medicine release mechanism is arranged to release medicine to the hepatopancreatic ampulla, inflammation caused by abnormal metabolism at the hepatopancreatic ampulla is solved, and the hepatopancreatic ampulla is prevented from being damaged by abnormal metabolism at the hepatopancreatic ampulla. And by arranging the bulges, bile and pancreatic juice excreted by drainage are uniformly mixed.

The invention discloses a multi-segment gastric bypass stent, which comprises a support frame main body and a separator arranged outside the support frame main body in a wrapping manner, the support frame main body sequentially comprises a first segment, a second segment, a third segment and a fourth segment from top to bottom, and the first segment is used for being matched, abutted and matched with a gastric antrum part in a limiting manner; the second section is used for abutting against the duodenum ball part in a limiting fit mode. The third section is provided with a framework and is arranged in the duodenum; the diameter of the fourth section is larger than that of the third section, and the fourth section is matched with the peristalsis of the duodenum to stretch the support frame main body towards the extension direction of the support frame main body; the third section comprises a non-clinging section matched with the hepatopancreatic ampulla, and the non-clinging section is used for discharging bile and pancreatic juice from the hepatopancreatic ampulla; and the separator is used for separating the chyme from the duodenum. The multi-section stomach bypass support is reasonable in structure, can prevent the stomach bypass support from blocking the hepatopancreatic ampulla, guarantees normal work of the hepatopancreatic ampulla, and avoids the occurrence of diseases such as pancreatitis.

The present invention provides a self-assembling peptide gel for use in preventing a leak of digestive fluid and a self-assembling peptide gel for use in protecting an organ against digestion by a digestive fluid. The self-assembling peptide gel comprises a self-assembling peptide and water, whereby the self-assembling peptide gel has an adhesion persistence ratio with respect to a collagen sheet of at least 40% and a decomposition ratio of 35% or less in pancreatic juice treatment at 37°C for 7 days, and the self-assembling peptide gel is positively charged as a whole.

The present disclosure relates to a medical tissue adhesive for pancreatic plugging and the preparation method and use thereof. The medical tissue adhesive composition forming the medical tissue adhesive of the present disclosure comprises a medical tissue adhesive component and a chelating agent component; wherein the medical tissue adhesive component comprises a first component and a second component, the first component comprises four-arm polyethylene glycol amine, and the second component comprises four-arm-polyethylene glycol-succinimidyl glutarate; wherein m and n are natural numbers; and the chelating agent component comprises polyphenol. The medical tissue adhesive prepared from the medical tissue adhesive composition of the present disclosure is capable of firmly binding to the surface of the pancreatic tissue, and is capable of withstanding the dynamic pressure as a result of pancreatic juice leakage and the enzymatic degradation activity of pancreatic juice. More importantly, the medical tissue adhesive of the present disclosure has an excellent antibacterial ability and is capable of preventing the infection caused by the long-term accumulation of the leaked pancreatic juice.

The utility model relates to medical instrument technical field especially, and it is a kind of covered stent and implantation system.This covered stent includes support framework and film, wherein: support framework is the hollowed out cylinder structure of peripheral surface, it can be radially compressed and expand;Film is coated on part support framework, and drainage mesh is formed at the region of support framework not being coated by film.Due to film being coated on part support framework, drainage mesh is formed at the region of support framework not being coated by film, bile of gallbladder, bile in common hepatic duct and pancreatic juice in pancreatic duct can enter the inside of covered stent through drainage mesh and reach duodenal papilla, thereby avoiding the phenomenon that bile and pancreatic juice cannot flow out from common bile duct and reach duodenal papilla due to common bile duct being pressed by stent, and simultaneously, a plastic stent does not need to be additionally implanted in common bile duct to help common bile duct drainage, to achieve the purpose of reducing operation cost and operation complexity.

The utility model discloses a bile and pancreatic juice filtration drainage bag, which comprises a drainage bag, a connecting device, a measuring cup, a filter screen, a drainage tube, an adjusting switch and a constant temperature pot, the connecting device comprises a connecting tube and a connecting assembly, one end of the connecting tube is connected with an external patient end, and the other end of the connecting tube is connected with the drainage bag; the connecting assembly is movably arranged on the connecting pipe; the measuring cup is arranged in the drainage bag; the filter screen is arranged at the top of the measuring cup; the drainage tube is arranged at the bottom of the measuring cup; and the adjusting switch is arranged on the drainage tube. Therefore, the fixing assembly is arranged, stable connection with the external patient end is guaranteed, it can be guaranteed that the device cannot be loosened or disengaged due to external force in the drainage process, the double-layer filtering structure is arranged, the upper-layer filtering net is provided with relatively large filtering holes, large-particle impurities and solids are preliminarily intercepted, the lower-layer filtering net is relatively fine, and the filtering effect is good. And tiny particles and suspended matters are further filtered.

The application provides a fluorescent probe, a preparation method and application thereof, and relates to the technical field of chemical analysis and detection. The fluorescent probe comprises a compound represented by formula (I) or a salt thereof. The application provides a probe capable of being used for rapid detection and imaging of pancreatic juice leakage in operation and after operation. The probe has good stability and optical performance, high selectivity and sensitivity, and the preparation method is simple.

This invention discloses an intelligent monitoring and repair system for gastrointestinal anastomoses, relating to the fields of medical devices and biomedical engineering technology. The system includes a bioresponsive sealing adhesive, an intelligent drainage catheter, and an external intelligent terminal. The sealing adhesive covers the surface of the anastomosis and releases colorimetric and fluorescent signals under the action of gastric, intestinal, or pancreatic juice. The intelligent drainage catheter has a main drainage chamber, a pneumatic monitoring chamber, an optical conduction channel, and a perfusion chamber, with an anti-adhesion cage at its tip. The external intelligent terminal is used for optical detection and vacuum attenuation determination. This system can achieve local sealing of the anastomosis, identification of abnormal signals, and monitoring of catheter status.

The utility model relates to a pancreatic duct support, belongs to the technical field of medical instruments, and solves the technical problem that a pancreatic duct is mistakenly touched or mistakenly cut due to the fact that an existing pancreatic duct support cannot be positioned. The pancreatic duct stent comprises a pancreatic duct stent body, a supporting device, a communicating hole and a magnetic particle coating layer, the pancreatic duct stent body is arranged in a pancreatic duct, the supporting device is arranged on the pancreatic duct stent body to prevent the pancreatic duct stent body from shifting in the pancreatic duct, and the communicating hole is formed in the pancreatic duct stent body to enable pancreatic juice to flow into the pancreatic duct stent body; the magnetic particle coating layer is arranged on the pancreatic duct stent body. According to the pancreatic duct stent, the magnetic particle coating layer is arranged on the pancreatic duct stent body, the pancreatic duct stent body can be positioned through imaging equipment according to the characteristics of the magnetic particles, a doctor can conveniently and accurately know the position of the pancreatic duct stent body in the body, and the distance between the stent and a scalpel can be judged according to the position of the pancreatic duct stent body in the body; and the condition that the pancreatic duct is mistakenly touched or cut is effectively reduced.

The invention discloses a bile and pancreatic juice diversion catheter set which comprises guide wires (1), a diversion catheter (2), a pushing catheter (3) and an outer sheath tube (4), the diversion catheter (2) is installed at the head end in the outer sheath tube (4), one end of the pushing catheter (3) is inserted from the tail end of the outer sheath tube (4), the number of the guide wires (1) is two, and the number of the guide wires (1) is two. And the two guide wires penetrate through the shunting catheter (2) and the pushing catheter (3). The device can be arranged in the bile duct and the pancreatic duct, can block pancreatic-bile reflux, does not affect the normal physiological structure and function of the human body, and is suitable for all patients.

To provide a material or a method capable of replacing a conventional digestive fluid leakage preventing material and a conventional digestive fluid leakage preventing method.SOLUTION: The digestive fluid leakage prevention material of the present invention contains a self-assembling peptide gel, has an adhesion residual ratio of at least 40% with respect to a collagen sheet, and has a degradation rate of 35% or less when treated with pancreatic fluid at 37 °C for 7 days.SELECTED DRAWING: None

The invention discloses a pancreas-intestine anastomosis magnetic ring support and belongs to the technical field of anastomators, the pancreas-intestine anastomosis magnetic ring support comprises a secondary magnetic ring, a primary magnetic ring, a pancreas supporting tube and a tube locking assembly, the secondary magnetic ring is in a circular ring shape, a plurality of needle holes are formed in the end face in a penetrating mode, the primary magnetic ring is in a circular ring shape and is magnetically connected with the secondary magnetic ring, and the pancreas supporting tube is inserted into the secondary magnetic ring and the primary magnetic ring. The locking tube assembly is arranged on the outer side wall of the mother magnetic ring and used for fixing the pancreas supporting tube. The problems that in the prior art, due to the fact that a pancreas supporting tube is fixed through interference fit between the pancreas supporting tube and a magnetic ring, the tightness of the pancreas supporting tube is difficult to control reliably, the pancreas supporting tube is prone to displacement or a tube cavity is pressed, and then pancreatic juice leakage, unsmooth drainage and postoperative pancreatic fistula risk increase are caused are solved. The clinical practicability and the pertinence are relatively high.

This invention relates to the field of microbial technology, providing *Streptococcus salivarius* subsp. *thermophilus* JIAN+ and its applications. The preservation number of this *Streptococcus salivarius* subsp. *thermophilus* JIAN+ is CGMCC No. 27130. This *Streptococcus salivarius* subsp. *thermophilus* JIAN+ can effectively inhibit α-amylase and α-glucosidase, and its combination with white kidney bean has a synergistic effect on inhibiting α-amylase activity and α-glucosidase. Simultaneously, it has good scavenging ability against free radicals DPPH and OH, exhibiting antioxidant and reducing capabilities; it also has good antibacterial activity against *Escherichia coli*; it also has good tolerance to gastric and pancreatic juices, and as a natural strain, it has strong safety, providing a new probiotic source for the development of functional products such as weight loss products, blood sugar lowering products, and antioxidant products.

The present invention provides a laparoscopic pancreaticojejunostomy stapler. The laparoscopic pancreaticojejunostomy stapler includes a pancreaticojejunostomy stapler, and the pancreaticojejunostomy stapler includes a slender rod, an anastomosis cap, a through hole, and a pancreatic juice hole. The anastomosis cap is fixed on the slender rod. The slender rod is a hollow structure with the through hole, and one end of the slender rod has a pancreatic juice hole. The laparoscopic pancreaticojejunostomy stapler further includes a release device. The pancreaticojejunostomy stapler is disposed inside the release device. The release device includes a sleeve. The pancreaticojejunostomy stapler is disposed inside the sleeve, and the pancreaticojejunostomy stapler and the sleeve are coaxial. The laparoscopic pancreaticojejunostomy stapler proposed by the present invention can change the conventional method of suturing the pancreas and the gastrointestinal tract with sutures. The pancreaticojejunostomy stapler has the functions of reconstructing the passage for pancreatic juice to enter the digestive tract, preventing pancreatic juice leakage, and facilitating the connection of the anastomosis of the stomach and intestines and the pancreatic juice stump. Sutures are not required, and the anastomosis is convenient and firm.

The invention relates to medical tissue glue for pancreas plugging as well as a preparation method and application of the medical tissue glue. The medical tissue glue composition for forming the medical tissue glue disclosed by the invention comprises a medical tissue glue component and a chelating agent component, wherein the medical tissue glue component comprises a first component and a second component, and the first component comprises four-arm polyethylene glycol amine; the second component is prepared from four arm-polyethylene glycol-succinimide glutaric acid ester; wherein m and n are natural numbers; the chelating agent component comprises polyphenol. The medical tissue glue prepared from the medical tissue glue composition disclosed by the invention can be firmly adhered to the surface of pancreatic tissue and can bear dynamic pressure of pancreatic juice leakage and enzymatic degradation activity of pancreatic juice, and more importantly, the medical tissue glue disclosed by the invention has excellent antibacterial ability and can prevent infection caused by long-term accumulation of pancreatic juice leakage.

The utility model discloses a pancreatic duct stent, which belongs to the technical field of medical instruments and comprises a hollow stent body extending into a pancreatic duct and a retaining part positioned outside the pancreatic duct, more than one barb is arranged on the stent body, and a developing marking part is arranged at the front end of the stent body. Developing marking parts are arranged at the front end, the rear end and the retaining part of the stent body, so that the stent body is prevented from exceeding or not reaching a specified position when being put into the pancreatic duct. The two barbs are arranged on the stent body, and if the pancreatic duct section where one barb is located has inflammation, the other barb can also achieve position fixation when the barb cannot fix the stent in the pancreatic duct. The multiple drainage holes are formed, the drainage effect can be improved, pancreatic juice of the branch pancreatic ducts can be drained, and when one or more drainage holes are blocked, the other drainage holes can still keep the drainage effect. The length of the stent body is matched with the length of pancreatic ducts of most of Chinese people, the statistical result is met, sufficient drainage of pancreatic juice of the whole pancreatic section is guaranteed, and the actual clinical condition is better met.

The utility model discloses an adjustable negative pressure pancreatic juice drainage device, which relates to the technical field of medical supplies and comprises a drainage main pipe, a plurality of drainage ports are arranged at the tail of the drainage main pipe, the head of the drainage main pipe is fixedly communicated with a flushing shunt pipe and a negative pressure connecting pipe, and a sputum suction pipe is inserted into an opening of the negative pressure connecting pipe. A connecting device is arranged between the negative pressure connecting pipe and the sputum suction pipe for limiting; the connecting device provided by the utility model is made of a disposable medical plastic material, is not easy to generate adverse reaction when being in contact with a human body, is high in sanitation and safety, is convenient to assemble and disassemble, can realize the fixed limiting of the sputum suction tube and the adjustment of the suction force of negative pressure drainage, and is high in practicability.

The present invention provides a stiripentol liposome, a preparation method thereof and an application thereof. The stiripentol liposome comprises stiripentol, phospholipid and cholesterol with a mass ratio of (5-15):(50-150):(1-3), and is prepared by a combination of the thin film hydration method and the ultrasonic method. Stiripentol, phospholipid and cholesterol are dissolved in an appropriate amount of ethanol solution, and evaporated under reduced pressure until the ethanol is completely volatilized. An appropriate amount of water is taken for rotary hydration to uniformly disperse the liposome in water, and ultrasonic treatment is carried out in an ice bath, followed by filtration to obtain the product. The stiripentol liposome prepared by the present invention has a particle size of 50 nm to 250 nm and an encapsulation efficiency of 50% to 90.0%. It can remain stable in gastric juice and pancreatic juice, can be rapidly dissolved in an aqueous medium, and significantly improves the in vivo bioavailability. The preparation method provided by the present invention has the advantages of simple process, controllable process, better stability, etc., is easy to scale up and industrialize, and has a wide application prospect.

The pancreatic duct drainage device comprises a first drainage tube, one end of the first drainage tube is arranged on a main pancreatic duct in the using process, the other end of the first drainage tube extends into the jejunum, and the pancreatic duct and the jejunum are communicated through the first drainage tube so as to create an artificial fistula. And the pancreatic juice can smoothly enter the jejunum, so that the possibility of pancreatic-intestinal anastomotic fistula is reduced. In the embodiment, the first drainage tube is formed by sequentially splicing a plurality of first tube sections end to end, every two adjacent first tube sections are connected through a connecting piece made of biodegradable materials, and after the first drainage tube is placed in the body of a patient for a period of time, the connecting pieces are degraded, so that the first drainage tube is decomposed into a plurality of first tube sections; therefore, the first tube section can discharge the first drainage tube out of the body through the jejunum, and automatic tube drawing of the first drainage tube is achieved.

The present invention provides a pancreatico-enteric stapler comprising a slender rod, an anastomosis cap, a through hole, and a pancreatic fluid hole. The anastomosis cap is fixed to the slender rod. The slender rod is a hollow structure with the through hole, and one end of the slender rod has a pancreatic fluid hole. The present invention proposes a novel pancreatico-enteric / gastric anastomosis method and apparatus that can replace the traditional method of suturing the pancreas and stomach with sutures. The pancreatico-enteric stapler can reestablish a pathway for pancreatic fluid to enter the digestive tract, prevent pancreatic fluid leakage, and facilitate the connection of the anastomosed stomach and pancreatic fluid stump. No sutures are required, and the anastomosis is convenient and secure.

The application relates to the technical field of a biliopancreatic chronic disease remote cooperative management system, and particularly discloses a biliopancreatic chronic disease remote cooperative management system. The system comprises a medical image data acquisition unit, an individualized anatomical model construction unit, a biliopancreatic fluid dynamics simulation engine, a virtual intervention simulation unit, a risk early warning analysis unit and a remote cooperative diagnosis and treatment platform; a digital twin model of a biliopancreatic duct system of a patient is constructed, the biliopancreatic fluid flow state is simulated in combination with computational fluid dynamics, and virtual stent implantation and other intervention effect pre-performance are supported, so that identification of occult obstruction and quantitative evaluation of a treatment scheme are realized; the system also supports multi-territory expert cooperative consultation, dynamic model updating and risk grading early warning. Through the technical scheme, a leap from morphological diagnosis to functional diagnosis is realized, and early lesion detection rate, individualized diagnosis and treatment level and remote cooperation efficiency are improved.

The utility model relates to a blood vessel stump protective sleeve, which comprises a blood vessel clamp and a protective bag, the blood vessel clamp comprises an upper clamping arm, a connecting part and a lower clamping arm, the upper clamping arm is connected with the lower clamping arm through the connecting part, the connecting part is provided with an adjusting hole, the upper clamping arm is provided with a lock hook part, the lower clamping arm is provided with a fixing part, and the fixing part is provided with a fixing hole. The fixing part is used for being matched with the lock hook part; the protection bag is provided with an opening, the opening is integrally connected with the vascular clamp, and when the vascular clamp clamps the stump end of a blood vessel, the vascular clamp closes the opening of the protection bag. Different from the prior art, the vascular clamp is provided with the protection bag, the vascular clamp is clamped at the residual end of a blood vessel through the clip applier, the residual end of the blood vessel is protected through the protection bag, and the residual end of the blood vessel is prevented from being corroded by pancreatic juice, digestive tract fluid and the like; the blood vessel stump can be protected by only one step without being divided into two steps, so that the steps are simple, and the use is convenient.

The invention relates to the technical field of medical instruments, in particular to a pancreatic juice drainage tube flusher used after pancreas operation, which comprises a handle and a drainage tube, and further comprises a chip scraping assembly, the handle is connected with the drainage tube, the drainage tube comprises an inner tube and an outer tube, the inner tube is coaxially arranged in the outer tube, and the chip scraping assembly is arranged in the outer tube. The chip scraping assembly is arranged in the outer tube and connected with the lower ends of the inner tube and the outer tube, a plurality of side holes are formed in the circumferential side of the outer tube in a circumferential array mode, and when flushing fluid is conveyed from top to bottom in the inner tube and flushing fluid mixed with adipose tissue fragments is sucked into the outer tube through the side holes, the chip scraping assembly is impacted to rotate; when the scrap scraping assembly rotates, adipose tissue fragments at the outlet end of the side hole are scraped. Through the arranged scrap scraping assembly, normal discharge of flushing fluid is achieved on the basis of preventing the side holes from being blocked by fat fragments, and then the condition of a patient is prevented from being aggravated.

The present application relates to the field of cosmetic technology, and in particular to a preparation method of hydrolyzed collagen, which simulates the in-vivo natural digestion process by using saliva, gastric juice, pancreatic juice and bile to prepare hydrolyzed collagen from bullfrog skin, and has mild conditions and retains biological activity to the greatest extent; the synergistic effect of multiple digestive juices precisely cuts the collagen molecular chain to generate fragments with reasonable structure and excellent activity, making up for the limitations of single enzyme or a small number of enzymes in enzyme method. The acid-base reagent is abandoned to eliminate the risk of chemical residues, ensure product safety from the source, effectively reduce immunogenicity, and overcome the problems of structure damage and antigen epitope exposure caused by acid-base method. The reaction conditions are based on the stable physiological parameters of human digestive juice, and the temperature and pH value are easy to control, so as to ensure the stable product quality; in terms of cost control, the dependence on expensive commercial enzymes can be reduced, and no acid-base wastewater is generated, which has significant environmental benefits, and truly realizes the overall upgrading of the preparation process.