52 results about "Pancreatic Fluid" patented technology

The invention provides a duodenal internal covering membrane, which is made of degradable shape memory biocompatible material and relates to degradable medical equipment internally installed in a digestive tract. After the internal covering membrane is implanted into a duodenum, chyme can be split from bile and pancreatic juice, so stomach exudates are prevented from being directly digested, absorbed and metabolized in the duodenum, and the histocompatibility is good; after being implanted into a human body, the duodenal internal covering membrane is steady, is not easy to slide off to be incarcerated and can be gradually degraded in the human body after 2 months to 5 years, so complicated operation and the injury to organs and tissue, which are caused when the duodenal internal covering membrane is removed from the human body in the future, are avoided, a rebound effect achieved after the original barrier is instantaneously and thoroughly dismounted can be slowed down, and the duodenal internal covering membrane can be prepared into medical equipment which is used for curing obesity and diabetes mellitus and does not need to be removed from the human body in the future; and tube-shaped part sinking induced by gastrointestinal motility and jejunum content backflow caused by the decrease of a gap between a tube-shaped part of the internal covering membrane and the inner wall of the duodenum can be avoided. The prepared medical equipment for curing the obesity and the diabetes mellitus can achieve the effects of dropping prevention, removal exemption, rebound inhibition and injury reduction.

The invention discloses application of lectin group recognized carbohydrate chains in distinguishing mucinous cystic neoplasm from serous cystic neoplasm. The lectin group recognized carbohydrate chains disclosed by the invention are glycosylated protein carbohydrate chains recognized by lectin groups consisting of WGA (trticum vulgaris agglutinin), BPL (bauhinia purpurea lectin), STL (solanum tuberosum (potato) lectin), DBA (dolchos biflorus agglutinin), PTL-I (psophocarpus tetragonolobus lectin I) and MAL-I (maackia amurensis lectin I). The carbohydrate chains are different in capsula pancreatic fluid of patients suffering from mucinous cystic neoplasm and serous cystic neoplasm, the contents of the carbohydrate chains recognized by STL, WGA, BPL and DBA in the capsula pancreatic fluid of patients suffering from MCN (mucinous cystic neoplasm) are remarkably higher than those in the capsula pancreatic fluid of patients suffering from SCN (serous cystic neoplasm), the contents of the carbohydrate chains recognized by PTL-I and MAL-I in the capsula pancreatic fluid of the patients suffering from MCN are remarkably lower than those in the capsula pancreatic fluid of the patients suffering from SCN, the sensitivity of the combination of WGA and BPL in distinguishing the patients suffering from SCN from the patients suffering from MCN is 0.714, and the specificity is 1. The results show that the lectin group can be used for distinguishing the patients from SCN from the patients suffering from MCN.

One solid preparation of the present invention mainly includes silicon fine particles, and has a capability of generating hydrogen. In addition, one specific example of the solid preparation mainly includes silicon fine particles having a crystallite diameter principally of 1 nm or more and 100 nm or less, and exhibits a capability of generating hydrogen in an amount of 3 ml/g or more when brought into contact with a water-containing liquid having a pH value of 7 or more. In this solid preparation, hydrogen is generated when the silicon fine particles are brought into contact with a water-containing liquid having a pH value of 7 or more. Therefore, taking advantage of the characteristics of the solid preparation, generation of hydrogen is promoted in, for example, a gastrointestinal tract where the pH value is 7 or more due to secretion of pancreatic fluid after passage through the stomach after oral ingestion.

The invention discloses a pancreas islet separation device and method. The device comprises a cavity and a filtration mechanism, wherein the filtration mechanism divides an inner cavity of the cavityinto a first cavity and a second cavity, the first cavity is provided with a first opening, and the second cavity is provided with a second opening. In the device, the filtration mechanism divides thecavity into two cavities, after a pancreas digests in one cavity, released pancreas islet is filtered through the filter mechanism from the first cavity to the second cavity, the second opening is unscrewed intermittently, pancreatic fluid in the second cavity is released, so that the pancreas islet is not digested excessively. The device has a simple structure, is low-cost and is convenient to operate.

A method is provided for evaluating the suitability of a duodenal fluid sample collected from an animal as a sample for detecting pancreatic fluid-derived components. The method comprises: (a) mixing a duodenal fluid sample with a chymotrypsin-specific substrate and measuring an amount of degradation the chymotrypsin-specific substrate by of the duodenal fluid sample, (b) mixing the duodenal fluid sample with a pepsin-specific substrate and measuring an amount of degradation of the pepsin-specific substrate by the duodenal fluid sample, and (c) evaluating that the duodenal fluid sample is suitable as a sample for detecting pancreatic fluid-derived components if the amount of degradation of the chymotrypsin-specific substrate by the duodenal fluid sample is higher than a prescribed threshold value and the amount of degradation of the pepsin-specific substrate by the duodenal fluid sample is lower than a prescribed threshold value, as being suitable as a sample for detecting pancreatic fluid-derived components.

The invention relates to a Model Gut System (MGS) comprising a pancreatic phase consisting essentially of synthetic pancreatic juice comprising pancreatin and one or more suitable pancreatic diluent(s) at a pH from about 7 to about 9, preferably about 7.9 to about 8.2, and porcine bile.

The invention discloses a simple in-vitro dynamic digestion simulation device and a use method. The in-vitro simulation digestion device comprises a simulation oral cavity part, a simulation stomach part and a simulation small intestine part which are arranged in a constant-temperature box and are connected in sequence; a first bracket, a second bracket and a third bracket are arranged in the constant-temperature box; the simulation oral cavity part is an oral cavity reaction bottle, and the oral cavity reaction bottle is hung below the first bracket; and the simulation stomach part is composed of a gastric juice storage bottle and a gastric reaction bottle, wherein the gastric reaction bottle is hung below the second bracket, and the gastric juice storage bottle is connected below the first bracket. The device is simple in structure and low in implementation cost, the gastrointestinal simulation digestion stage is not static and unchanged, the device is close to the processes of gastric secretion, gastric emptying, biliary secretion, pancreatic juice secretion and the like of the human body, and the real digestion process of the human body can be better simulated. All the parts can be split and combined, the digestion condition of one or more parts is researched by combining the actual condition, and convenience is provided for experiments.

The invention discloses a slow-release stress-resistant probiotic crystal ball and a preparation method thereof. The slow-release stress-resistant probiotic crystal ball comprises a probiotic inner core layer, a slow-release layer, a stress-resistant layer and a protective layer which are sequentially arranged from inside to outside, wherein the probiotic inner core layer is of a spherical structure, and the surface of the probiotic inner core layer is sequentially coated with the slow-release layer, the stress-resistant layer and the protective layer. The probiotic inner core layer is wrapped with the material of the slow-release layer, the material of the stress-resistant layer and the material of the protective layer in sequence through a pot coating method to obtain the slow-release stress-resistant probiotic crystal ball. The probiotic crystal ball membrane material with better stress resistance is prepared, and the stress-resistant membrane can better protect the probiotics in the membrane, so that the probiotics are prevented from being damaged and inactivated by gastric acid, cholate, pancreatic juice and the like in the digestive tract during use, and an ideal effect is exerted.

Provided are a method for exclusively selecting a duodenal fluid sample having a high possibility of containing pancreatic fluid and favorable sample suitability for subjecting to detection of a pancreatic disease marker by evaluating the quality of the sample prior to detecting the pancreatic disease marker, and a method for detecting a pancreatic disease marker using a duodenal fluid sample selected according to that method. Namely, a method is provided for selecting a duodenal fluid sample for detecting a pancreatic disease marker, comprising: (a1) a step of comparing the color depth of a duodenal fluid sample with a prescribed standard color, and (b1) a step of determining that a duodenal fluid sample is subjected to a test for a pancreatic disease marker if the color depth thereof is equal to or higher than the standard color, but that the duodenal fluid sample is not subjected to a test for a pancreatic disease marker if the color depth thereof is lower than the standard color.

The invention provides a pancreas and intestine anastomat. The pancreas and intestine anastomat comprises a slender rod, an anastomosis cap, a through hole and a pancreatic juice hole, wherein the anastomosis cap is fixed on the slender rod, the slender rod is of a hollow structure with the through hole, and the pancreatic juice hole is formed in one end of the slender rod. The invention provides a novel pancreas-intestine/stomach anastomosis method and apparatus. The method and the apparatus can change a conventional method of suturing pancreas and stomach and intestine with sutures, the pancreas and intestine anastomat has the functions of reconstructing a passage for pancreatic juice to enter a digestive tract, preventing the pancreatic juice from leaking and conveniently connecting and anastomosing the stomach and intestines and a pancreatic juice stump, no sutures are needed, and the anastomosis is convenient and firm.

The invention belongs to the fields of biomedicine and high polymer material, and relates to a radioactive bracket for treating malignant tumor of digestive tract and the preparation method thereof. The bracket combines the radionuclide with the molecular surface of a degradable material, so as to produce radioactive biodegradation brackets of different concentrations for treating malignant tumor of digestive tract; the radioactive bracket for treating malignant tumor of digestive tract consists of a digestive tract bracket, an inner layer, an outer layer and positioning tube sleeves; the digestive tract bracket is coated with the inner layer, bilateral sides of the inner layer are provided with the positioning tube sleeves, and the outer layer wraps the inner layer and the positioning tube sleeves, wherein the inner layer is prepared by the mixture of a biocompatible high polymer material and a radioactive substance, the outer layer is a biocompatible high polymer material, and the positioning tube sleeves are made of stainless steel. The bracket can not only ensure the effective drainage of bile and pancreatic juice, but also treat the tumor with the locally precise radiotherapy effect; the bracket is safe, reliable, low cost, simple in preparation method, strong in practicability, and favorable application prospect.

The invention relates to the technical field of medical instruments, in particular to a self-expanding stent for pancreaticojejunostomy. The self-expanding stent for pancreaticojejunostomy comprises aself-expanding stent body which is columnar after being expanded; one end of the self-expanding stent body is provided with a stent pancreas end, and the position, close to the end, of the other endof the self-expanding stent body is provided with a stent jejunum end protruding outwards after being expanded. The surface of the self-expanding stent body is coated with a membranous material layerfor preventing pancreatic juice from leaking. The self-expanding stent has the advantages that the risk of pancreatic fistula is greatly reduced, meanwhile, the operation time is shortened, and the operation risk is reduced.

The invention relates to a fixable pancreas duct built-in tube with holes. The pancreas duct comprises a pancreas duct built-in tube, the pancreas duct built-in tube is made of semitransparent silicagel, the total length of the pancreas duct built-in tube is 100-150 mm, the diameter of the pancreas duct built-in tube is 1.8-2.2 mm, drainage holes are evenly formed in the pancreas duct built-in tube from left to right along the tube wall, and fixing lugs are arranged on the pancreas. The pancreatic duct drainage tube has the advantages that the pancreatic duct drainage tube is simple in structure and convenient to use, outflow of pancreatic juice can be increased to a greater extent by the aid of the pancreatic duct drainage hole, and outflow efficiency of the pancreatic juice is improved;and the tube wall can be better fixed by the fixing lugs on the pancreatic duct built-in tube, so that the built-in tube is prevented from slipping, and a better drainage effect is achieved.

A body fluid leakage detection aqueous composition, for use e.g. in intraoperative pancreatic fluid leakage detection. The composition comprises a gelling agent, increasing the viscosity of the composition, and buffering species, the composition thereby being buffered. The gelling agent is cross-linked alpha-glucan microspheres. Further, the composition comprises a pH-indicator. The pH of the composition is at least 0.1 pH units lower, or higher, than a pKa of the pH-indicator.

The invention belongs to the technical field of medical apparatus and instruments, and particularly relates to a bile and pancreatic juice drainage tube with a calculus removing saccule, which comprises a needle head, a first drainage tube is fixedly arranged at the side end of the needle head, a connecting part is fixedly arranged at the side end of the first drainage tube, a liquid collecting cavity is formed in the connecting part, and a second drainage tube is fixedly arranged at the side end of the first drainage tube. Symmetrical threaded holes are formed in the side wall of the connecting part, a connecting pipe is detachably arranged in the threaded hole in one side, a sealing plug is detachably arranged in the threaded hole in the other side, and a sealing gasket attached to the pipe wall of the connecting pipe is fixedly arranged on the outer side wall of the threaded hole located in the liquid collecting cavity. Firstly, the drainage space of the first drainage tube can be enlarged through the arrangement of the connecting part, bile pancreatic juice can be conveniently collected through the liquid collecting cavity formed in the connecting part, in this way, the buffering and collecting effect can be achieved, the connecting tube can be conveniently and alternately replaced when blockage occurs through the arrangement of the two threaded holes, and in this way, the connecting tube can be directly replaced when blockage occurs.

A degradable stapler for constructing a bile-pancreatic fluid bypass port comprises two interlocking ball rings, a link guide cylinder is vertically arranged on the edge of the ball ring with small relative diameter, the connecting guide barrel is composed of a plurality of uniformly spaced first arc pieces and a second arc piece, the outer diameter of the first circular arc piece is smaller thanthe inner diameter of the second circular arc piece, the first circular arc piece is provided with a buckle body, the inner side of the second circular arc piece is provided with a positioning card body and a closing card body matched with the buckle body of another ball ring, and the positioning card body is positioned above the closing card body; the closed card body is a two-stage closed card body, and the buckle body is buckled with the two-stage closed card body twice. By using the invention, the digestive tract with different wall thicknesses of different patients can be adapted, and thehealing requirements of the bile-pancreatic bypass orifice in an alkaline environment can be met.

The invention relates to a C-shaped wrapping type pancreatic fistula resistant drainage device. The C-shaped wrapping type pancreatic fistula resistant drainage device is characterized by comprising adevice main body and a multi-cavity tube, wherein the device main body comprises a first curve segment body and a second curve segment body, one end of the first curve segment body and one end of thesecond curve segment body are connected and integrally shaped, the other end of the first curve segment body and the other end of the second curve segment body are in dismountable connection, and after the other end of the first curve segment body and the other end of the second curve segment body are connected, an annular drainage channel is formed by inner walls of the first curve segment bodyand the second curve segment body; and a through hole is formed in the device main body, and one end of the multi-cavity tube is connected with the through hole. In the use process of the device, whenleaking, pancreatic liquid can be drained by the through hole of the drainage channel to the multi-cavity tube to be drained as soon as possible, so that drainage of the leaked pancreatic liquid is convenient, and drainage efficiency and drainage reliability are improved; and besides, the situation that the leaking pancreatic liquid is in contact with surrounding tissue blood vessels to cause corrosion can be avoided. In addition, the multi-cavity tube is used for realizing closed type cycle flushing, so that flushing liquid cannot leak to an abdominal cavity, and the safety is improved.