The invention discloses an investment potential evaluation method of a regional comprehensive energy system. The method comprises the steps of clustering the typical users, extracting a typical energyconsumption curve, and carrying out the reasonable analysis and calculation on the overall energy consumption condition of a region; designing and establishing a regional energy system basic model and a comprehensive energy system optimization operation model, based on the above model, obtaining the profit of the regional comprehensive energy system, and determining the total investment of the comprehensive energy system, thereby carrying out the economic analysis, calculating the indexes, such as the internal yield, the unit profit, etc., and carrying out the quantitative evaluation on the market potential of the construction of the regional development comprehensive energy system. According to the method, the profitability and the cost recovery of the investment construction of the regional comprehensive energy system can be effectively analyzed, the inter-regional market potential is visualized and prioritized, the reference is provided for the regional energy system planning, thescientific guidance is provided for the construction investment of the regional comprehensive energy system, and the economic rationality of the calculation and evaluation can be better reflected in the current energy internet development and construction form.