The invention discloses henhouse disease prevention disinfectant powder, and relates to the technical field of laying hen breeding. The henhouse disease prevention disinfectant powder is prepared from the following raw materials in parts by weight: 20 to 25 parts of quicklime, 20 to 30 parts of plant ash powder, 8 to 10 parts of andrographis paniculata water-extracting solid, 9 to 15 parts of scutellaria baicalensis water-extracting solid, 5 to 15 parts of berberine water-extracting solid, 6 to 8 parts of allicin water-extracting solid, 7 to 9 parts of rheum officinale water-extracting solid, 2 to 10 parts of houttuynia cordata water-extracting solid, and 6 to 8 parts of a preservative. The henhouse disease prevention disinfectant powder disclosed by the invention is reasonable in formula; natural sterilization formulae are mixed and allocated reasonably; the henhouse disease prevention disinfectant powder is reasonable, safe, quick in effect and low in cost, facilitates the enhancement of laying hen immunity, prevents diseases, resists diseases, does not have a toxic or side effect and does not pollute the environment.