The invention relates to a friction nanometer power generator for converting mechanical energy to electric energy and a fabrication method of the friction nanometer power generator. The fabrication method comprises the steps of packaging a flexible substrate layer I, an electrode material layer I, an electrical negative friction layer, an electrical positive friction layer, an electrode material layer II and a flexible substrate layer II according to a sequence, and then connecting the two flexible substrate layer at the outmost layer so that the electrical negative friction layer and the electrical positive friction layer are arranged at intervals to fabricate the friction nanometer power generator, wherein the electrical negative friction layer is fabricated by automatically assembly a friction electrical negative substance on a surface of aerogel. The fabricated friction nanometer power generator for converting the mechanical energy to the electric energy comprises the electrical negative friction layer and the electrical positive friction layer, and the electrical negative frication layer mainly comprises nanometer fiber of the self-assembled friction electrical negative substance. The fabrication method is simple, the fabricated product is low in cost, the sensitivity on mechanical energy of tiny biology is high, the electrical output performance is excellent, and the frication nanometer power generator has favorable application prospect in the field of self power supply sensing and wearability.