The invention discloses a manufacturing method of a variable cross-section pipe fitting, which comprises the steps of blanking a plate sheet, heating, performing mould extrusion, allowing extruded plate blanks to be welded into the variable cross-section pipe fitting, and performing heat treatment, appearance inspection, finishing, grinding, rough processing, flaw detection, hardening and tempering, finish turning, inspection and delivery, wherein in the step of blanking the plate sheet, the plate sheet is cut into two plate blanks, and in the step of the mould extrusion, an upper mould and a lower mould are adopted, and after the plate blanks are placed in the lower mould, the upper mould applies a downward force on the plate blanks, so that the plate blanks are extruded between the upper mould and the lower mould till half pipe walls of the variable cross-section pipe fitting are formed. The manufacturing method has the advantages that with the adoption of the manufacturing method, the interior of the produced variable cross-section pipe fitting does not collapse; the length of the variable cross-section pipe fitting is not changed; the variable cross-section pipe fitting is not distorted; and the surface of the variable cross-section pipe fitting is smooth and clean without folds, cracks or other forging defects.