The invention discloses a large-power dual-wire pulse MIG (metal-inert gas welding) power supply digital man-machine interactive system, comprising a hardware part and a software part; the hardware part comprises a DSP (digital signal processor) minimum system module, a liquid crystal display module, a touch control module, an RAM (random access memory) data storage module, an EEPROM (electrically erasable programmable read-only memory) data storage module, a real-time clock module and an SCI communication module; the DSP minimum system module is respectively correspondingly connected with the liquid crystal display module, the touch control module, the RAM data storage module, the EEPROM data storage module, the real-time clock module and the SCI communication module one by one; meanwhile, the SCI communication module is connected with a lower computer power supply controller; the software part comprises development of drive programs of all peripheral devices, multi-machine communication design based on an RS232 bus and the design on the operation menu of a man-machine interface. Precise determining, displaying, storing and calling of welding parameters of the large-power dual-wire pulse MIG can be realized, and the large-power dual-wire pulse MIG power supply digital man-machine interactive system has the advantages of small size, light weight, simple operation and the like.